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SMAD4 as a therapeutic target in hoxa9-related leukemia
Estimating the population size of specialised solitary bees
1. Reliable methods for quantifying population size are crucial for strategies to conserve endangered wild-bee species. Estimates of population size obtained through survey walks were compared with estimates obtained through mark-recapture studies in 10 populations of the red-listed solitary bee Andrena hattorfiana in southern Sweden. 2. The mean number of bees observed during survey walks was str
Negotiation and policy-making in the European Union: Processes, system and order
Isoprene emission from wetland sedges
High latitude wetlands play an important role for the surface-atmosphere exchange of carbon dioxide (CO2) and methane (CH4), but fluxes of biogenic volatile organic compounds (BVOC) in these ecosystems have to date not been extensively studied. This is despite BVOC representing a measurable proportion of the total gaseous C fluxes at northern locations and in the face of the high temperature sensi
Familial hypercholesterolemia: ethical, practical and psychological problems from the perspective of patients.
The main aim of the study was to explore the extent to which familial hypercholesterolemia (FH) influences the life of the patients affected. The study employed a qualitative analysis of semi-structured interviews with 23 outpatients who were being treated following a diagnosis of heterozygous FH at a tertiary hospital in Göteborg, Sweden. Some interviewees reported concerns related to their medic
Cardiovascular effects of induced hypothermia after lung transplantation
BACKGROUND: Induced hypothermia may be used to reduce metabolism in acute respiratory failure. Hypothermia is accompanied by an increase in pulmonary vascular resistance, as also seen in the early period after lung transplantation. It was our concern that the combination of the two would lead to an increased workload on the right ventricle. METHODS: To test this hypothesis we induced hypothermia t
Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women
Homocysteine has been suggested to be a risk factor for fracture, but the causal relationship is not clear. In 996 women from the OPRA study, high homocysteine level was associated with high bone marker levels and low BMD at baseline. During a mean 7-year follow-up, high homocysteine level was associated with mortality, but no clear association to fracture risk existed.
Antioxidant levels and inhibition of cancer cell proliferation in vitro by extracts from organically and conventionally cultivated strawberries
The effects of extracts from five cultivars of strawberries on the proliferation of colon cancer cells HT29 and breast cancer cells MCF-7 were investigated, and possible correlations with the levels of several antioxidants were analyzed. In addition, the effects of organic cultivation compared to conventional cultivation on the content of antioxidants in the strawberries and strawberry extracts on
Investigation of non-reflective boundary conditions for computational aeroacoustics
6-Thioguanine therapy in Crohn's disease-Observational data in Swedish patients
Background and aims. Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety. Methods. We evaluated in a prospective manner the tolerance
The lower Cambrian eodiscoid trilobite Calodiscus lobatus from Sweden : morphology, ontogeny and distribution
Ontogenetic scaling of fish metabolism in the mouse-to-elephant mass magnitude range
Intraspecific or ontogenetic analyses of mass-metabolism relationships do not often conform to the same allometric correlations as those seen in interspecific analyses. A commonly cited reason for this discrepancy is that ontogenetic studies examine smaller mass ranges than interspecific studies, and are therefore not statistically comparable. In this study the metabolic rate of yellowtail kingfis
Oligosaccharides from faeces of a blood-group B, breast-fed infant
Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk.
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A thoracic chimney graft is a stent or stent graft that is deployed in a supraaortic branch vessel, protruding somewhat proximally into the free aortic lumen like a chimney parallel to the main aortic stent graft. The chimney graft is used to preserve flow to vital aortic side branches covered by the main aortic stent graft. Standard off-the-shelf stent grafts can be used to instantly treat lesion
Low-dose midazolam antagonizes cerebral metabolic stimulation by ketamine in the pig
In order to test the hypothesis that low-dose midazolam reduces excitatory cerebral symptoms by attenuating ketamine-induced increases in the cerebral metabolic rate for oxygen (CMRO2), we compared the cerebral effects of a combination of an anesthetic dose of ketamine hydrochloride (10.0 mg.kg-1 i.v.) and a subanaesthetic dose of midazolam maleate (0.25 mg.kg-1 i.v., n = 6; or 0.10 mg.kg-1 i.v.,
Poly(acrylamide-allyl glycidyl ether) cryogel as a novel stationary phase in dye-affinity chromatography
Poly(acrylamide-allyl glycidyl ether) [poly(AAm-AGE)] cryogel was prepared by bulk polymerization which proceeds in an aqueous solution of monomers frozen inside a glass column (cryo-polymerization). After thawing, the monolithic cryogel contains a continuous polymeric matrix having interconnected pores of 10-100 mu m size. Cibacron Blue F3GA was immobilized by covalent binding onto poly(AAm-AGE)
The prognostic impact of karyotypic subgroups in myelodysplastic syndromes is strongly modified by sex
The prognostic impact of karyotypic patterns in a consecutive series of 389 adult myelodysplastic syndromes (MDS) was investigated. Time period did not significantly influence the survival times. In the analyses, the MDS cases were subdivided into the cytogenetic subgroups used in the International Prognostic Scoring System, i.e. favourable [-Y, del(5q) or del(20q) as single aberrations or normal
Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to ident
International use of health status questionnaires in Parkinson's disease: translation is not enough.
The present study assessed the linguistic and content validity of the Swedish version of the 39-item Parkinson's disease questionnaire (PDQ-39). The frame question, response alternatives and two of the 39 items yielded substantial linguistic and stylistic problems. Such shortcomings would be expected to influence responses to, and the quality of, the whole questionnaire. Data support content valid