Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a functional

This thesis is about structure preserving numerical integration of initial value problems, i.e., so called geometric numerical integrators. In particular, we are interested in how time-step adaptivity can be achieved in conjunction with structure preserving properties without destroying the good long time integration properties which are typical for geometric integration methods. As a specific app

Popular Abstract in Swedish De senaste 150 åren har erbjudit en dramatisk utveckling av vår förmåga att sprida både njutningar och smärta, både i form av upptäckter av ämnen såsom TNT och dynamit och framställningen av heroin och Viagra. Denna utveckling har följts av teknologiska framsteg som tillåter studier av dessa kemikalier genom deras interaktion med till exempel radiosignaler eller laser. Modern spectroscopic techniques, such as nuclear quadrupole resonance (NQR), nuclear magnetic resonance (NMR), and Raman spectroscopy, rely heavily on statistical signal processing systems for decision making and information extraction. The first part of this thesis introduces novel robust algorithms for detection, estimation, and classification of signals obtained through these spectroscopic tech

Recension av Adolf Hitler, Den nationalsocialistiska utrikespolitikens mål.

Abstract in UndeterminedThe point of departure in my story is the contrast between two models of democratic voting process: popular democracy and what might be called committee democracy. On one interpretation, voting in popular democracy is a procedure whose function is to aggregate the individuals’ preferences to something like a collective preference, while in committee democracy what is being

Objectives - To assess long-term functioning and disability after traumatic brain injury (TBI). Material and methods - Individuals (n = 88) in Norrbotten, northern Sweden, who had been transferred for neurosurgical care were assessed with internationally established TBI outcome measures 6-15 years post-injury. Results - There was an improvement in overall outcome from discharge from inpatient reha

This paper analyzes the term structure of interest rates in an exchange-only Lucas (Econometrica 46:1429–1445, 1978) economy where consumers learn about a stochastic growth rate through observations of the endowment process and an external public signal. We allow for deluded consumers, who exaggerate the degree of covariation between the external public signal and the growth rate. With such consum

Abstract in Undetermined Patienter måste kunna lita på att Läkemedelsverket i både i skrift och handling ställer deras rätt till korrekt information över läkemedelsindustrins intressen. Risken är annars överhängande att verkets trovärdighet i läkarnas och allmänhetens ögon urholkas, något som i förlängningen kan få allvarliga medicinska konsekvenser.

In higher plants, thylakoid membrane protein complexes show lateral heterogeneity in their distribution: photosystem (PS) II complexes are mostly located in grana stacks, whereas PSI and adenosine triphosphate (ATP) synthase are mostly found in the stroma-exposed thylakoids. However, recent research has revealed strong dynamics in distribution of photosystems and their light harvesting antenna alo

OH radicals play an important role in pollutant removal in nonthermal plasmas. It is crucial to clarify the behavior of OH radicals in this process. A time-resolved 2-D OH radial distribution was investigated in a pulsed corona discharge by planar laser-induced fluorescence at atmospheric pressure and room temperature. The OH evolutions under different gas components were studied, and the evolutio

Dowry payments from the family of the bride to that of the groom were rarely encountered in Kerala during the early twentieth century, but now are almost universal. Based on an examination of historical documents, including legislative debates, court cases, and reports, the way dowry was explained in the past is compared with the results of 200 contemporary interviews to determine its current rati

Resource allocation in clouds is mostly done assuming hard requirements, applications either receive the requested resources or fail. Given the dynamic nature of workloads, guaranteeing on-demand allocations requires large spare capacity. Hence, one cannot have a system that is both reliable and efficient. To solve this issue, we introduce Service Level (SL) awareness in clouds, assuming applicati

Bell's palsy is an acute unilateral weakness or paralysis of the face of unknown cause. The incidence of the disease is 30 individuals per 100,000 per year. It is a diagnosis of exclusion and other known causes for acute peripheral facial palsy must be ruled out. The prognosis is overall favorable and about 70% of the patients recover completely within 6 months without treatment. Recent randomized

Categorization of rhythmic patterns is prevalent in musical practice, an example of this being the transcription of (possibly not strictly metrical) music into musical notation. In this article we implement a dynamical systems’ model of rhythm categorization based on the resonance theory of rhythm perception developed by Large (2010). This model is used to simulate the categorical choices of parti

Prior studies of IPO underpricing, mostly using agency theory and single-country samples, have generally fallen short. In this study, we employ the knowledge-based view (KBV) to explore underpricing across 17 countries. We find that agency indicators are insignificant predictors, board of director knowledge limits underpricing, and external knowledge both substitutes for and complements internal b

Acute myeloid leukemia (AML) is a heterogeneous disease of the myeloid lineage. About 35% of AML patients carry an oncogenic FLT3 mutant making FLT3 an attractive target for treatment of AML. Major problems in the development of FLT3 inhibitors include lack of specificity, poor response and development of a resistant phenotype upon treatment. Further understanding of FLT3 signaling and discovery o

The present article analyses the mediatization of the brand and celebrity Zlatan Ibrahimovic using the reception and marketing of the footballer's life story and autobiography as its main case. It is shown that the construction of a myth such as Ibrahimovic transcends the materiality of the book as well as geographical, vernacular and media boundaries, as it is constituted as content in a digital

This article proceeds from a conceptual analysis of how ontological (in)security is constructed in terms of ‘security-of-being’ in which identity dynamics are explicated in socio-psychological terms. Of particular interest is how such dynamics transcend the boundaries of individual self/other constructions to define communities and states, and how these dynamics are transformed in times of trauma

The article examines leader ship as an aspect of everyday work inter actions. Drawing on the findings of an ethnographically inspired study of superior-subordinate relations in a bank, it argues that leader ship can be understood as embedded in everyday work-activities, rather than seen as distinct from these. Relying on the framework of discursive psychology, a micro-level analysis of an informal