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On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

Popular Abstract in Swedish RB-GENEN SKYDDAR OSS MOT CANCER OCH STYR UTMOGNADEN AV BLODCELLER. Frisk och sjuk blodbildning: Varje dag bildas det ungefär ett tusen miljarder blodkroppar av olika sorter i vår benmärg. Varje dag, livet ut. Denna imponerande massproduktion av celler är livsnödvändig. Dom vita blodkropparna ser tex till att vi inte dukar under i infektioner, dom röda transporterar deThe aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. Cells used were human leukemic cell lines an

Design of a claw-pole motor

This paper describes a design of two miniature claw-pole motors, one single phase and one two-phase motor. Both motors are designed to be built in iron powder technology. The designs are optimized and the static characteristics determined by 3D FE modeling. Both motors are being built by separate companies, but no measurements are presented in this paper. The main goal is to evaluate the industria

Quantitative Imaging of Equivalence Ratios in DME Sprays Using a Chemically Preheated Combustion Vessel

Dimethyl Ether (DME) has proved to be a promising fuel for diesel engines. It virtually eliminates particulate emissions and reduces the formation of nitrogenous oxides, without negatively affecting engine efficiency. Obtaining a deeper understanding of the mechanisms behind these properties is thus highly desirable. Various authors have suggested that the low NO emissions associated with DME are

Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs

Popular Abstract in Swedish Dagens behandling av cancer, inklusive blodmaligniteter, har blivit mer effektiv genom andvändning av potenta, cytostatiska läkemedel. Cytostatika medför att patienternas normala infektionsförsvar försvagas och att risk finns för livshotande infektioner, särskilt i perioder av neutropeni(lågt antal vita blodkroppar). Det är viktigt att dessa patienter vid infektionsteckThe aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on th

Rethinking Explanation

This volume is a product of the international research project Theory of Explanation,which was funded by the Joint Committee for Nordic Research Councils for the Humanities and the Social Sciences (NOS-HS). The project started in 2001 and operated for a period of three years by organizing a number of workshops on scientific explanation in Norway, Iceland, Sweden and Finland. The workshops included

Design and Performance of a Hybrid Ventilation System with Heat Recovery for Low Energy Buildings

A new hybrid ventilation system for low energy buildings has been investigated theoretically using TRNSYS. The system is based on natural ventilation but utilizes a fan during hours when the natural driving forces are not sufficient. Heat from the exhaust air is recovered in an air-to-water heat exchanger. The heated water is pumped to the incoming ventilation air where it is heat exchanged to pre

NMR Studies of Gel-Emulsions; Diffusometry and Applications of Novel Field Gradient Techniques

Popular Abstract in Swedish Avsikten med detta arbetet har varit att utveckla kärnmagnetisk resonans, NMR, tekniken, applicerat på gel-emulsioner. Gel-emulsioner är viktiga i många tekniska formuleringar så som i livsmedel, i kosmetika, i läkemedelsformuleringar och i sprängmedel för att nämna några applikationer. Vi har arbetat med en teknik som kallas NMR diffusometri, som utvecklats av StejskalThe aim of these studies has been to investigate what information that can be obtained on gel-emulsions with nuclear magnetic resonance, NMR, as the investigating tool. The gel-emulsions are important in many technical applications such as in food products, in cosmetic and pharmaceutical formulations, and in emulsion explosives, just to name a few applications. We have worked with the NMR diffusom

”’Den kungliga skölden’ – Per Albin Hansson, Gustaf V och medierna 1940”

The chapter compares the media roles of the Swedish monarchy with that of the country's Labor Movement. In focus are the ways in which these two institutions used and were used in the visual culture of Sweden during World War Two. It is predominantly the official roles of king Gustaf V and prime minister Per-Albin Hansson that are under scrutiny, not least the common media platforms of these two i

Particle generation from humans - a method for experimental studie in cleanroom technology

Particle generation from humans is a severe problem when working in cleanrooms and other controlled environments. Data regarding the number of particles generated by humans are few and there are no detailed references as to how these studies have been performed. An experimental method to determine the particle release from a human being in a cleanroom was developed and used to describe the variati

Approximate distance oracles for geometric graphs

Given a geometric t-spanner graph G in Ed with n points and m edges, with edge lengths that lie within a polynomial (in n) factor of each other. Then, after O(m+n log n) preprocessing, we present an approximation scheme to answer (1+ε)-approximate shortest path queries in O(1) time. The data structure uses O(n log n) space.

Environmentally Friendly Disposal Behaviour and Local Support Systems: lessons from a metropolitan area.

The amount of household refuse has steadily increased in Sweden and this is consistent with the trend in the rest of the European Union. Strategies for household waste reduction includes sorting, recycling, re-use and repair. Two categories of motivational factors determine disposal behaviour, external and internal. The external factors include administrative, economic, information and physical me