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Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome

Opsoclonus myoclonus syndrome (OMS), often called "dancing eyed syndrome," is a rare neurological condition associated with neuroblastoma in the majority of all childhood cases. Genomic copy number profiles have shown to be of prognostic significance for neuroblastoma patients. The aim of this retrospective multicenter study was to analyze the genomic copy number profiles of tumors from children w

LSC - 2017 - Hippo-YAP/TAZ signaling is deranged in IPF

Objective: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure and is characterized by deranged epithelial repair, myofibroblast activation, and excess deposition of extracellular matrix. Yes associated protein (YAP) and transcriptional co-regulator with PDZ-binding domain(TAZ), co-transcriptional activators of the Hippo pathway and proto-oncogenes, were recently found to be

Rescue Effect Inherited in Colony Formation Assays Affects Radiation Response

It is well known that nonirradiated cells can exhibit radiation damage (bystander effect), and recent findings have shown that nonirradiated cells may help protect irradiated cells (rescue effect). These findings call into question the traditional view of radiation response: cells cannot be envisioned as isolated units. Here, we investigated traditional colony formation assays to determine if they

Characteristics of BVOC emissions from a Swedish boreal forest : Using chambers to capture biogenic volatile organic compounds (BVOCs) from trees and forest floor

Plant-emitted biogenic volatile organic compounds (BVOCs) are a large group of hydrocarbons released by plant leaves, bark, flowers and fruits into the atmosphere and from plant roots into the soil. BVOCs have important physiological and ecological functions, such as mediating within-plant and plant-plant communication, defense against herbivores attack, protection against heat or other oxidative

The biology of color

Coloration mediates the relationship between an organism and its environment in important ways, including social signaling, antipredator defenses, parasitic exploitation, thermoregulation, and protection from ultraviolet light, microbes, and abrasion. Methodological breakthroughs are accelerating knowledge of the processes underlying both the production of animal coloration and its perception, exp

Performance and manufacturability tradeoffs of different electrical machine designs

This work addresses the manufacturability challenges in traction machine production systems and design. The tradeoffs between performance and manufacturability of a heavy duty traction machine for buses and trucks, are investigated for four different winding designs, with multiple stator combinations, all using the same interior permanent magnet rotor. We present an analysis of electromagnetic, th

Managing soil natural capital : a prudent strategy for adapting to future risks

Farmers are exposed to substantial weather and market related risks. Rational farmers seek to avoid large losses. Future climate change and energy price fluctuations therefore make adaptating to increased risks particularly important for them. Managing soil natural capital—the capacity of the soil to generate ecosystem services of benefit to farmers—has been proven to generate the double dividend:

Structural and optical properties of Cu2ZnSn(S,Se)4 films obtained by magnetron sputtering of a Cu2ZnSn alloy target

Results of the study of structural and optical properties of Cu2ZnSn(S,Se)4 thin films obtained by sulfitation (selenization) of Cu2ZnSn films which were sputtered by target direct current magnetron sputtering using a stoichiometric Cu2ZnSn (99.99%) target are presented. It has been found that Cu2ZnSn(S,Se)4 thin films are polycrystalline with a grain size of ~60 nm. The optical bandgap of Cu2ZnSn

Autonomic deployment decision making for big data analytics applications in the cloud

When changes happen to big data analytics (BDA) applications in the Cloud at runtime, the affected BDA applications have to be re-deployed to accommodate the changes. Deciding the most suitable deployment is critical and complicated. Although there have been various research studies working on BDA application management, autonomic deployment decision making is still an open research issue. This pa