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This paper reports the observation of top-quark pair production in proton-lead collisions in the ATLAS experiment at the Large Hadron Collider. The measurement is performed using 165 nb−1 of p+Pb data collected at sNN = 8.16 TeV in 2016. Events are categorised in two analysis channels, consisting of either events with exactly one lepton (electron or muon) and at least four jets, or events with two
