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Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that have fueled the hope for sustainable biofuel production since they enhance the breakdown of recalcitrant polysaccharides like cellulose. In the consensus mechanism, their catalytic activity relies on forming an ‘oxyl’, [CuO˙−]+, species at the active site, followed by subsequent hydrogen atom abstraction (HAA) from the s
