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On Creation, Nature, and the Ethical Self: a Comparative Analysis of Ikhwān al-Ṣafāʾ, al-Rāghib al-Iṣfahānī, and Abū Ḥāmid al-Ghazālī : عن الخَلق والطبيعة والذات الأخلاقية: تحليلٌ مقارنٌ لأفكار إخوانِ الصفاء والراغبِ الأصفهانيّ وأبي حامد الغزالي

In this paper, I examine ideas on creation, nature, and the ethical self as conceptual-ized by the Ikhwān al-Ṣafāʾ (Brethren of Purity, fl. ca. 350–369/961–980) and al-Rāghibal-Iṣfahānī (d. before 409/1018), with a particular focus on Abū Ḥāmid al-Ghazālī(d. 505/1111). Drawing from the classical scholarship on kalā m, taṣawwuf, and falsafa,I analyze texts by these ethicists who wrote on nature an

In search of common ground - nephrologists’ experiences in preparing and informing patients on the path to end-stage kidney disease

BackgroundPatient education and dialogue are important when choosing a future treatment strategy for patients with chronic kidney disease. To support patients in their decision-making process, it is critical to provide information in a way that patients can understand. This study was conducted to understand how nephrologists view the goals of information sharing, the challenges involved, and the s

The potential of overlooked material in museum repositories : Revisiting grave materials in Falbygden through multiproxy analyses

In this article we aim to highlight the potential of forgotten grave materials in our museum depositories for gaining insights into prehistoric life. By applying a multi-proxy approach to the skeletal remains of two graves of uncertain types from Falbygden in western Sweden, we were able to acquire new knowledge of burial practices, subsistence, health and mobility in Late Neolithic and Early BronIn this article we aim to highlight the potential of forgotten grave materials in our museum depositories for gaining insights into prehistoric life. By applying a multi-proxy approach to the skeletal remains of two graves of uncertain types from Falbygden in western Sweden, we were able to acquire new knowledge of burial practices, subsistence, health and mobility in Late Neolithic and Early Bron

A systematic review and meta-analysis of the fully formed wisdom tooth as a radiological marker of adulthood

Assessment of third molar development on dental radiograms is one of the most commonly used methods of forensic age estimation. Despite widespread use and numerous studies, there is a paucity of aggregated data on how well a fully mature third molar identifies adulthood (> 18 years), the most important threshold in a medicolegal context. Therefore, a systematic review and meta-analysis was conduct

Evaluation of the long-term cost-effectiveness of insulin detemir compared with neutral protamine hagedorn insulin in patients with type 1 diabetes using a basal-bolus regimen in Sweden

AIMS: To evaluate the long-term clinical and economic outcomes associated with insulin detemir and neutral protamine hagedorn (NPH) insulin in combination with mealtime insulin aspart in patients with type 1 diabetes in Sweden, based on data from a two-year, multi-national, open-label, randomized, controlled trial.METHODS: Insulin detemir was associated with significant improvements in glycaemic c

Electric Road Systems for Electric Vehicle Long-Distance Travel : A Multi-Agent Simulation Approach

Electric road systems (ERSs) present a transformative advancement in transportation electrification, offering continuous charging capabilities for electric vehicles (EVs) during travel. This innovation has the potential to significantly mitigate range anxiety by enabling in-motion charging, thereby enhancing the overall efficiency of electric mobility, and reducing the frequency of charging stops

Digitala daglönare i gig-ekonomin - En rättsvetenskaplig studio av arbetstagarbegreppet

De senaste åren har den digitaliserade ekonomin etablerats i Sverige. En del av utvecklingen är plattformsarbete eller gig-jobb, som innebär att korta uppdrag åt flera uppdragsgivare förmedlas via en digital delningsplattform eller app. Rättsreglerna är uppbyggda binärt, vilket förenklat innebär att det finns två möjliga system: det ena gäller för dem som är arbetstagare och det andra för dem som

PON-P3: Accurate Prediction of Pathogenicity of Amino Acid Substitutions

Different types of information are combined during variation interpretation. Computational predictors, most often pathogenicity predictors, provide one type of information for this purpose. These tools are based on various kinds of algorithms. Although the American College of Genetics and the Association for Molecular Pathology guidelines classify variants into five categories, practically all pat

Impact of segmental body composition on metabolic dysfunction-associated fatty liver disease in Chinese children

Purpose: This study aimed to assess the relationship between regional body composition and metabolic dysfunction-associated fatty liver disease (MAFLD) in Chinese children.Methods: In this study, 1399 children aged 7–14 years were included. Liver steatosis was assessed using the controlled attenuation parameter (CAP) measured through Fibroscan. MAFLD is defined as the presence of liver steatosis a

ctDNA as an Objective Marker for Postoperative Residual Disease in Primary Advanced High-Grade Serous Ovarian Cancer

Background/Objectives: The surgeon’s subjective intraoperative evaluation is the standard of care to assess postoperative residual disease (RD) in advanced epithelial ovarian cancer (EOC). We investigated the feasibility of ctDNA as an objective marker for postoperative RD. Methods: This prospective study included 27 patients with advanced ovarian cancer (FIGO IIIA1–IVB) who underwent primary surg

Targeting TUBG1 in RB1-negative tumors

The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met

National Pre-Authorisation Schemes and the EU's Demands for Objectivity Safeguards – Allowing Policy Discretion while Streamlining Administrative Process

The chapter focuses on how process is reviewed in the general framework of EU legal analysis applicable to national pre-authorisation schemes. By examining the model of judicial review developed by the Court of Justice in this regard, I hope to enrich the discussion on what process federalism within the Union can look like and how it may function. After some brief explanations regarding the charac

Healthy ageing for older adult people with intellectual disability : a scoping review

BACKGROUND: The increasing longevity of people with intellectual disability creates a need for a healthy-ageing perspective, translated into evidence-based interventions in this multi-morbidity group. Accordingly, the aim of this scoping review was to identify, summarise and analyse the empirical research on healthy ageing in older adults with intellectual disability.METHODS: This review was based