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Neuroendocrine effects in printing workers exposed to toluene

The effect of exposure to toluene on plasma concentrations of testosterone, prolactin, luteinising (LH) and follicle stimulating (FSH) hormones was investigated in 47 rotogravure printers (time weighted average air toluene below 80 ppm; blood toluene concentration post-shift 0.19-7.99 mumol/l) and compared with a reference group. Increasing exposure concentrations of toluene (concentrations less t

Hormone status in occupational toluene exposure

Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-we

The blunting of the thyrotropin response to repeated thyrotropin-releasing hormone administration is reduced by dopaminergic blockade both at normal and elevated serum levels of thyroid hormones

Fifteen premenopausal women were investigated in the follicular phase of the menstrual cycle with two TRH tests within an interval of 48 to 96 h. Ninety min before each TRH test either 10 mg metoclopramide or saline was injected iv in randomized order. The same procedure was repeated in the following menstrual cycle after pretreatment with T4 (0.5 mg daily for 6-14 days). At least 2 months later t

Normal pituitary hormone response to thyrotrophin and gonadotrophin releasing hormones in subjects exposed to elemental mercury vapour

Exposure to elemental mercury (Hg) vapour results in an accumulation of Hg in the pituitary, the thyroid, and the testis. In this study, basal serum concentrations of pituitary hormones (thyrotrophin (TSH), prolactin (PRL), follicle stimulating hormone (FSH), and luteinising hormone (LH] or their response after administration of thyrotrophin and gonadotrophin releasing hormones did not differ betw

Plasma neuropeptides in hyperthyroidism

Plasma levels of the neuropeptides, vasoactive intestinal polypeptide (VIP, neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P, and galanin were determined in 15 hyperthyroid patients before and at 3 occassions during 38 weeks of treatment. Treatment was performed with either 131I alone or with carbimazole, with combination of carbimazole and thyroxine, or with subtotal thyr

Suppressed plasma prolactin response to thyrotropin-releasing hormone in hyperthyroidism reproduced by thyroxine but not by triiodothyronine administration to normal subjects

In 10 hyperthyroid women studied in the follicular phase of the menstrual cycle, basal plasma PRL was normal, but PRL release after TRH was significantly suppressed compared with that in 11 control women. The suppressed PRL response to TRH was not explained by changes in serum estradiol or sex hormone-binding globulin. It recovered after treatment of hyperthyroidism. When normal women were treated

Increased plasma gonadotropin levels in spontaneous hyperthyroidism reproduced by thyroxine but not by triiodothyronine administration to normal subjects

In nine hyperthyroid women studied in the follicular phase of the menstrual cycle basal plasma LH concentrations and LH and FSH responses to GnRH were increased compared to those in nine normal women. The increased gonadotropin levels could not be related to changes in body weight or plasma estradiol or serum sex hormone-binding globulin levels, and they approached normal levels during or after tr

Thyroid hormone metabolism in thyroid disease as reflected by the ratio of serum triiodothyronine to thyroxine

In 77 euthyroid subjects the mean ratio between serum triiodothyronine (S-T3) in nmol/l X 10(3) and serum thyroxine (S-T4) in nmol/l was 22.4 with a standard deviation of 4.3. The distribution of the ratio was close to Gaussian. It was not changed in subjects under estrogen effect. The ratio was increased in hypothyroid subjects suggesting a mechanism preserving S-T3 better than S-T4 in thyroid fa

Normal reference interval for thyrotropin response to thyroliberin : dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin

We measured the thyrotropin response (delta TSH) to 200 micrograms of thyroliberin in 131 subjects without thyroid dysfunction or other disease and with basal values for thyroid function that were within the normal reference intervals for our laboratory. By univariate and multivariate statistical methods we found delta TSH to be significantly influenced by the basal concentration of thyrotropin (T

Improving the Efficacy of Enuresis Alarm Treatment through Early Prediction of Treatment Outcome : A Machine Learning Approach

Introduction: Bedwetting, also known as enuresis, is the second most common chronic health problem among children and it affects their everyday life negatively. A first-line treatment option is the enuresis alarm. This method entails the child being awoken by a detector and alarm unit upon urination at night, thereby changing their arousal mechanisms and potentially curing them after 6–8 weeks of

Methylxanthine for the prevention and treatment of apnea in preterm infants

BACKGROUND: Very preterm infants often require respiratory support and are therefore exposed to an increased risk of chronic lung disease and later neurodevelopmental disability. Although methylxanthines are widely used to prevent and treat apnea associated with prematurity and to facilitate extubation, there is uncertainty about the benefits and harms of different types of methylxanthines.OBJECTI

Automated actual evapotranspiration estimation : Hybrid model of a novel attention based U-Net and metaheuristic optimization algorithms

Actual evapotranspiration (ETa) plays a crucial role in the water and energy cycles of the earth. An accurate estimate of the ETa is essential for management of the water resources, agriculture, and irrigation, as well as research on atmospheric variations. Despite the importance of accurate ETa values, estimating and mapping them remains challenging due to the physical and biological complexity o

Global Soil moisture trend analysis using microwave remote sensing data and an automated polynomial-based algorithm

The change in Soil Moisture Content (SMC) is one of the most crucial variables for regulating and analyzing basic hydrological processes, including runoff, evaporation, carbon and energy cycles, infiltration of water resources, droughts and floods, and desertification. This study aimed to detect and map the global SMC change using microwave remote sensing observations. Monthly SMC data from the So

Violence and victim souls : Exploring the connection of gender-based violence, beatification, and Christian theology of suffering

Commencing from the question “what makes mysticism feminine?” (a medical-historical conception of female bodies being receptive to some forms of mystical experiences? following an idea of gendered embodiment, a specific feminine spiritual corporeality?), the presence of forms of violence preceding the beatification or sanctification of women as victim souls caught my attention.Examples like Laura