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The structure and dynamics of intrinsically disordered proteins (IDPs) are malleable to solution conditions. Considerable effort has been devoted to understanding the effects of molecular crowding on these properties. Polymer-based crowders, such as polyethylene glycol (PEG) and Ficoll®, are commonly used to simulate the intracellular environment by replicating the high concentration of macromolec
The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these novelties arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell type atlas of the telencephalon of the s
We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25–64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absol
This study examined pathways to quality-of-life (QOL) among hotel staff facing job insecurity, considering the roles of customer orientation, organizational commitment, leadership, and job engagement. A research model was developed and tested using path analysis on survey data, comparing groups with high and low job insecurity. Results showed the model explained 43.3 % of variance in QOL. Customer
Background: In cardiovascular magnetic resonance, late gadolinium enhancement (LGE) is the standard method to visualize myocardial infarction (MI). Many algorithms quantifying infarct size in LGE images exist. However, only few algorithms have been validated, i.e., benchmarked against an ex-vivo measurement. Furthermore, the reported algorithm performance varies considerably between studies. Objec
Historians of knowledge recognize that scientific knowledge is insepa- rable from ideology, which means that the intertwinement of the epistemic and the political constitutes a key topic of study. However, historians of knowledge have thus far not focused sufficiently on intersections with religiosity and spiritu- ality. To address this gap, this article introduces the numinous as a complemen- tar
This chapter explores the intersection of authenticity, commercialization, and influencer culture in digital fashion media through the case study of Swedish retailer Ellos’ “Made by Women” campaign. Using a qualitative methodology, the study investigates how brands instrumentalize personal narratives to create emotional engagement while serving commercial interests. The findings reveal a paradox o
Background: Calcitonin gene-related peptide (CGRP) release from trigeminal structures is central to migraine pathophysiology. This study employed an ex vivo model preserving anatomical continuity between the trigeminal nucleus caudalis (TNC) and trigeminal ganglion (TG) to investigate (1) whether TNC stimulation induces peripheral CGRP release from the TG and (2) the potential involvement of a dis
Excitation energy transfer between photosynthetic light-harvesting complexes is vital for highly efficient primary photosynthesis. Controlling this process is the key for advancing the emerging artificial photosynthetic systems. Here, we experimentally demonstrate the enhanced excitation energy transfer between photosynthetic light-harvesting 2 complexes (LH2) mediated through the Fabry-Pérot opti
The long-term effects of COVID-19, known as post-COVID condition (PCC), are still not fully understood. This systematic review synthesizes findings from Nordic registry studies to highlight long-term outcomes after COVID-19 infection. Twenty-two studies, primarily reflecting the pre-omicron and early vaccination phases, reveal increased primary care use for respiratory issues and fatigue in the su
This was a retrospective cross-sectional study evaluating the aetiology and antibiotic susceptibility in patients treated for suspected bacterial keratitis at Skåne University Hospital during 2019. Inclusion criteria: eyes with bacterial keratitis. Exclusion criteria: co-infection with other microbes. Primary outcome parameters: predisposing factors, causative pathogens and antibiotic susceptibili
Research excellence instruments (REIs) are among the most popular types of research funding in several research systems, including the Global South. A significant proportion of REIs is intended to promote pathbreaking or groundbreaking contributions. Specific research outcomes can often be traced back to a given project’s scientific objectives, but projections about the impact on the field and the
We describe a method to estimate child mortality using linked IPUMS full-count census data for the decades following the 1850, 1860, 1870, 1900, 1910, 1920, and 1930 censuses. We compare the estimates to several external sources and conclude that the method represents a viable way to estimate and model child mortality at individual and aggregate levels over the course of the mortality transition.
The transition from batch-wise to integrated continuous manufacturing of biopharmaceuticals has gained significant attention over the past decade. While this concept has been thoroughly studied, there remains significant room for improvement in terms of process automation and real-time monitoring. This study showcases the implementation of an integrated downstream process at a lab scale, operating
Background: Older adults are underrepresented in suicide prevention research, even though suicide rates are higher in this age group (65+) than in any other age group in many countries worldwide. There are few clinical intervention studies that target this age group. A promising preventive intervention is the Attempted Suicide Short Intervention Program (ASSIP). Given differences in suicidal behav
