Exploration of Methods for Solubility Studies of Amyloid Beta
The protein amyloid beta (Aβ) is a major component in the amyloid plaques associated with Alzheimer’s disease. This project concerns the most common version of this protein, Aβ40. In a supersaturated solution, Aβ40 monomers can aggregate to form amyloid fibrils. The solubility of an amyloid protein is equal to the concentration of the monomeric peptide in solution at equilibrium. To study the solu