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Background: Harmful glucose exposure and absorption remain major limitations of peritoneal dialysis. We previously showed that inhibition of sodium glucose cotransporter 2 did not affect glucose transport during peritoneal dialysis in rats. However, more recently we found that phlorizin, a dual blocker of sodium glucose co-transporter 1 and 2, reduces glucose diffusion in peritoneal dialysis. Ther

BACKGROUND: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is useful for selected clinical indications in patients with prostate cancer (PCa) but it may have broader clinical utility owing to the emergence of lutetium-177-PSMA-617 ([177Lu]Lu-PSMA) therapy. However, robust data regarding the impact of PSMA PET/CT on patient management and treat

OBJECTIVE: To investigate to what extent individuals participated in guideline-based first-line treatments before being assigned to a wait list for knee replacement for osteoarthritis (OA), and to what extent they were recommended such treatments once on the list. Factors associated with participation in first-line management were also investigated.DESIGN: All patients on the waiting list ≥ three

The output of a 200 kHz, 34 W, 300 fs ytterbium amplifier is compressed to 31 fs with >88% efficiency to reach a peak power of 2.5 GW, which to date is a record for a single-stage bulk multi-pass cell. Despite operation 80 times above the critical power for self-focusing in bulk material, the setup demonstrates excellent preservation of the input beam quality. Extensive beam and pulse characteriza

The aim of this pilot study was to preliminary test the psychometric properties of the Multidimensional Measure of Parasocial Relationships (MMPR), a self-report that assess people's attitude (affect, cognition, and behavior) towards social media figures and to what extent people perceive that media figures influence their daily life decisions (e.g., consumption, exercise, nutrition). In short, th

BACKGROUND: Concerns remain about the human reproductive toxicity of the widespread per- and polyfluoroalkyl substances (PFAS) during early stages of development. OBJECTIVES: We examined associations between maternal plasma PFAS levels during early pregnancy and male offspring reproductive function in adulthood. METHODS: The study included 864 young men (age range:18.9-21.2 y) from the Fetal Progr

Knowledge about stroke and its management is growing rapidly and stroke systems of care must adapt to deliver evidence-based care. Quality improvement initiatives are essential for translating knowledge from clinical trials and recommendations in guidelines into routine clinical practice. This review focuses on issues central to the measurement of the quality of stroke care, including selection an

The structural and morphological properties of gadolinium oxide (Gd 2O 3) grown at high temperatures with molecular beam epitaxy on Si(001) were investigated for different stages of growth. The Gd 2O 3 layers were grown at 850 °C with different oxygen partial pressures and substrate miscuts. RHEED and XRD investigations indicate an initial formation of silicide and a subsequent transformation into

Microgravity-induced bone loss is a major concern for space travelers. Ground-based microgravity simulators are crucial to study the effect of microgravity exposure on biological systems and to address the limitations posed by restricted access to real space. In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular change

The thermal stability of monoclinic Gd2O3 grown on Si(001) as well as changes of the interfacial layer formed during the growth are investigated during rapid thermal annealing in nitrogen atmosphere between 600 °C and 1000 °C using x-ray diffraction and transmission electron microscopy (TEM). The monoclinic Gd2O3 layer was grown at 400 °C and oxygen partial pressure of 5 × 10−7 mbar. The Gd2O3 lay

Examples of Fell algebras with compact spectrum and trivial Dixmier-Douady invariant are constructed to illustrate differences with the case of continuous-trace C∗-algebras. At the level of the spectrum, this translates to only assuming the spectrum is locally Hausdorff (rather than Hausdorff). The existence of (full) projections is the fundamental question considered. The class of Fell algebras s

Background: Children in families who are refugees might experience more adversities than their peers. Adverse childhood experiences (ACEs) are well known risk factors for poorer adulthood health and adjustment. The risk of ACEs for children with a parent who is a refugee affected by trauma is unknown. We aimed to estimate the hazard of individual and cumulative ACEs using a unique sample of childr

The structural and dielectric properties of gadolinium oxide (Gd2O3) grown on Si(001) depending on the epitaxial growth conditions were investigated. Gd2O3 layers were grown at temperatures between 250 °C and 400 °C with an oxygen partial pressure between 2 x 10-7 mbar and 5 x10-7 mbar. The crystal structure of the Gd2O3 turns out to be monoclinic with rotational domains as revealed by x-ray diffr

INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior

Tensions between migration enforcement and migrants’ health and rights have gained renewed urgency during the COVID-19 pandemic. This article critically analyses how the pandemic has affected detained and deportable people in Sweden. Building on an activist methodological approach and collaboration, based on a survey conducted inside Swedish detention centres during the pandemic and the authors’ r

The multi-electrode electrical resistivity method has become one of the most efficient geophysical methods used in a wide range of applications, which is also suitable when disturbances in the ground are to be avoided. The selection of the right electrode configuration can provide better effectiveness, depending on the target being investigated. In this work a case of the use of three electrode arThe multi-electrode electrical resistivity method has become one of the most efficient geophysical methods used in a wide range of applications, which is also suitable when disturbances in the ground are to be avoided. The selection of the right electrode configuration can provide better effectiveness, depending on the target being investigated. In this work a case of the use of three electrode ar

Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom

Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), a

Increasing tree growth and mortality rates in Europe are still poorly understood and have been attributed to a variety of drivers. This study explored the role of climate drivers, management and age structure in driving changes in tree mortality rates in six Central European countries from 1985 to 2010, using the process-based vegetation model LPJ-GUESS. Simulations show a strong positive trend in

A substantial portion of molecules in an organism are involved in regulation of a wide spectrum of biological processes. Several models have been presented for various forms of biological regulation, including gene expression regulation and physiological regulation; however, a generic model is missing. Recently a new unifying theory in biology, poikilosis, was presented. Poikilosis indicates that