Calmodulin (CaM) is the central mediator of intracellular Ca2+ signalling in cardiomyocytes, where it conveys the intricate Ca2+ transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion ca

A Summary In a large cohort of elderly women followed for 10 years, we found that balance, gait speed, and self-reported history of fall independently predicted fracture. These clinical risk factors are easily evaluated and therefore advantageous in a clinical setting. They would improve fracture risk assessment and thereby also fracture prevention. Introduction The aim of this study was to identi

Objectives: To study: (I) work-loss seen as sick leave and disability pension before and after the start of first anti-TNF therapy in Swedish regional and national RA cohorts; (II) baseline predictors of a good future work prognosis at diagnosis and after anti-TNF start with a special focus on the impact of the disease activity level and the disease duration at treatment start. Methods: RA patien

The purpose of this study was to investigate women's wishes and need for knowledge concerning sexuality and relationships in connection with gynecological cancer. A total of 11 women were interviewed following the completion of their treatment for gynecological cancer. The data was analyzed using latent content analysis. Two main categories were identified: "The absence of knowledge about the body

Background: Persons with dementia receive health care and social services from a wide range of professional care providers during the disease trajectory, presenting risks of miscommunication, duplication and/or missed nursing interventions. Accordingly, the aim of this study was to investigate professional care providers' views on conditions for best practice in terms of collaboration and improvem

Modern industrial robots are traditionally programmed to follow desired trajectories, with the only feedback coming from the internal position/angle sensors in the joints. The robots are in general very accurate in tracking the desired motion, and they have become indispensable in many applications, such as spot welding and painting in the automotive industry. In more complex tasks, such as physic

Uncontrollable events such as adverse weather and volatile prices present considerable risks for arable farmers. Soil natural capital, which views the capacity of soil biodiversity to generate ecosystem services as a component of farm capital, could be important for the stability and resilience of arable production systems. We investigate therefore whether managing soil natural capital could be an

Popular Abstract in Swedish Hur lurar mördarbakterier våra celler? Neutrofiler och fagocytos räddar liv Utan vårt immunförsvar så skulle vi snabbt dö i infektioner från mikroorganismer. Det består ett komplicerat system av celler och molekyler som tillsammans kan klara av att stå emot attacker från bakterier, virus, svampar eller parasiter. Cellerna i immunförsvaret utgörs av vita blodkroppar ochNeutrophils are our most numerous and deadly white blood cells and without them we would succumb quickly to infections by pathogens. The main mechanism that the neutrophils employ for our protection is phagocytosis, where they eat and enclose their target inside a membrane-bound organelle, the phagosome. Neutrophil phagosomes are highly dynamic entities, and a large amount of antimicrobial substan

In order to achieve ultra-low emissions of both NOX and CO it is imperative to move the blow out limit towards leaner equivalence ratios and by supplying heat and reactive species to the flame zone the lean stability limit can be lowered. Heat and reactive species can be supplied to the flame zone by use of a pre-chamber combustor. In this study a central body burner, called the RPL (Rich-Pilot-Le

This paper presents a mathematical approach and numerical model that simulates beach and dune change in response to cross-shore processes of dune growth by wind and dune erosion by storms, and by gradients in longshore sand transport that will alter shoreline position. Sub-aerial transport processes are represented, whereas sub-aqueous transport is neglected. The system is tightly coupled morpholo

This article is a way to try to concretize the so-called new economy based on a couple of concrete expressions. The concepts of cultural heritage and consumption are used to describe and analyse some specific service operations in a couple of Swedish retailers. In both are the products manufactured, in one case, stone-baked sourdough bread and in the other handmade chocolates with reference to tra

This paper investigates how river privatisation in Turkey is deployed to expand renewable energy production and the implications this has for issues of ownership, rights to water and community life. Recent neoliberal reforms in Turkey have enabled the private sector to lease the rights to rivers for 49 years for the sole purpose of electricity production. The paper focuses on the re-scaling and re

Objective: The purpose of this study was to describe procedural changes in hospital incident investigations and show the consequences of these changes over time. Methods: A two-stage method was used. First component of the study was a content analysis of 87 incident investigations conducted 1995-2014 by the regulatory authority after adverse events in a Swedish university hospital. Second compone

The origin behind the dipolar order in molecular fluids is investigated by using a simple dipolar fluid and Monte Carlo simulation technique. A penalty function is employed to separately manipulate the positional and orientational structure of the fluid. By considering the distance-dependent Kirkwood function G (k), which in turn is related to the dielectric permittivity of the fluid, it is observ

There are emerging data to support a role for genetic and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. In this article, we review our recently published, large, population-based studies using data from Sweden and from United States veterans and propose mechanisms and pathways underlying our observations. We also discuss future directions

A comment on [W.J. Olds, A.R. McKinley, M.R. Moore, M.G. Kimlin, In vitro model of vitamin D(3) (cholecalciferol) synthesis by UV radiation: Dose-response relationships, J. Photochem. Photobiol. B: Biol. 93 (2008) 88-93]. The article also discusses some related issues.

Cross sections for elastic and proton-dissociative photoproduction of J/psi mesons are measured with the H1 detector in positron-proton collisions at HERA. The data were collected at ep centre-of-mass energies root s approximate to 318 GeV and root s approximate to 225 GeV, corresponding to integrated luminosities of L = 130 pb(-1) and L = 10.8 pb(-1), respectively. The cross sections are measured