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Epilepsy is a chronic neurological disease with high prevalence and adverse impacts on the quality of life of patients and caregivers. Up to one-third of individuals with epilepsy do not respond to current pharmacotherapy, underscoring the importance of identifying new molecules for epilepsy control. Thalidomide, the first synthetized phthalimide, is a neuroactive molecule with anti-seizure drug p

Software design in e-commerce can be improved with user data through controlled experiments (i.e. A/B tests) to better meet user needs. Machine learning-based algorithmic optimization techniques extends the approach to large number of variables to personalize software to different user needs. So far the optimization techniques has only been applied to optimize software of low complexity, such as c

Objectives The aim of this study is to determine diagnostic patterns in the prehospital paediatric population, age distribution, the level of monitoring and the treatment initiated in the prehospital paediatric case. Hypothesis was that advanced prehospital interventions are rare in the paediatric patient population. Setting We performed a retrospective population-based registry cohort study of ch

BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk

Tyendet (tjänstehjon) er en ofte overset gruppe i historieskrivningen. For første gang fortælles deres historie i en samlet oversigt.I 2021 er det 100 år siden, at tyendeloven blev ophævet. Der blev dermed sat punktum for århundreders tilsidesættelse af tjenestefolks rettigheder. F.eks. var det nu slut med den forhadte skudsmålsbog, og det var ikke længere tilladt at slå sine tjenestepiger og -drenge. Denne bog skildrer for første gang tjenestefolkets historie som en samlet fortælling. Den beskæftiger sig med både karle og pige

Against the backdrop of the ecological and climate emergencies and several other deep crises, advocates of degrowth call for democratic transitions towards societies that can thrive beyond economic growth within ecological boundaries while being socially equitable. In recent years, scholarship has emerged that brings together the emerging degrowth paradigm with insights from political economy. Yet

1. In normal mice, the distribution of adrenergic, cholinergic, some peptidergic, and neuronal nitric oxide synthase (nNOS)-containing nerves were investigated. Functional in vitro correlates were obtained. An in vivo model was developed in which erectile haemodynamics in response to drugs or nerve-stimulation were studied. 2. Immunoreactivities for vesicular acetylcholine transporter protein (VAC

We have examined whether in vivo exposure to the glutamate analogue, kainic acid, induces cell loss through apoptosis and/or through necrosis. The vulnerability of rabbit retinal cells was evaluated by routine histopathology. The DNA fragmentation was examined using an in situ method (TUNEL: TdT-mediated biotin-dUTP nick-end labelling) and agarose gel electrophoresis of extracted retinal DNA. Reti

This study analyzed the effect of breast-feeding on the frequency of acute otitis media. The protocol was designed to examine each child at 2, 6 and 10 months of age. At each visit nasopharyngeal cultures were obtained, the feeding pattern was recorded and the acute otitis media (AOM) episodes were documented. The analysis was based on 400 children from whom complete information was obtained. They