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Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to ident

Translation and psychometric evaluation of the Swedish versions of the Nuss Questionnaire modified for Adults and the Single Step Questionnaire

Background: Pectus excavatum (PE) is the most common congenital chest wall deformity. Most individuals with PE suffer from psychosocial problems, with low self-esteem and poor body image. Correctional surgery for PE is available, the most widely used is the Nuss procedure. The Nuss procedure has previously been reported to improve self-esteem, body image and health-related quality of life (HRQoL).

Assessing the compliance with the direction indicated by emergency evacuation signage

The type and relative position of evacuation signage to evacuees’ location can affect their likelihood to understand and comply with the information provided. To address this issue, a Virtual reality (VR) experiment with 60 participants was carried out to investigate the effect of signage vs viewer placement on the compliance with the indicated direction in case of evacuation. The VR experiments w

The Interday Repeatability of Parameters for the Assessment of Progressive Disease in Subjects With Less Advanced Keratoconus

Purpose: To evaluate the interday repeatability in the measurement of parameters used for the detection of progression of keratoconus by prediction limits (PL) for single measurements, and the repeatability coefficient (RC) for the mean of replicate measurements. Design: Prospective reliability analysis for cases and control eyes. Methods: Twenty-five eyes in 25 subjects with KC and 25 eyes in 25

Application of infrared radiation in the drying of food products

Background: Drying is an important method to preserve food products. Although many traditional drying technologies (hot air, freeze, microwave drying) have been applied successfully to various food products, each drying technique has its own advantages and disadvantages. Novel drying methods such as infrared drying, have become very popular. Scope and approach: This study gives an overview on the

The passenger’s influence on dwell times at station platforms : a literature review

Dwell time delays, although small in nature, can accumulate to a large delay over the entire journey of a train. It is, however, difficult to precisely know the amount of time which is required at stations due to the inherent variance in human behaviour. Furthermore, planning practices do not seem to capture the dynamic nature of the dwell time process. The current literature review focusses on th

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Since the start of the millennium, significant changes have been seen in Danish eldercare. Central is the political ambition of a paradigm shift from »help« to »help to self-self« in home care, which is envisioned to happen through reablement. Reablement refers to short-duration home-based training programmes through which applicants of publicly funded home care are sought re-enabled to manage pra

Machine learning algorithm-based risk assessment of riparian wetlands in Padma River Basin of Northwest Bangladesh

Wetland risk assessment is a global concern especially in developing countries like Bangladesh. The present study explored the spatiotemporal dynamics of wetlands, prediction of wetland risk assessment. The wetland risk assessment was predicted based on ten selected parameters, such as fragmentation probability, distance to road, and settlement. We used M5P, random forest (RF), reduced error pruni

A new hybrid model based on relevance vector machine with flower pollination algorithm for phycocyanin pigment concentration estimation

Precise monitoring of cyanobacteria concentration in water resources is a daunting task. The development of reliable tools to monitor this contamination is an important research topic in water resources management. Indirect methods such as chlorophyll-a determination, cell counting, and toxin measurement of the cyanobacteria are tedious, cumbersome, and often lead to inaccurate results. The quanti

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population

Nonspecific structural chromosomal aberrations (CAs) can be found at around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. The frequency of CAs has been measured in occupational monitoring and an increased frequency of CAs has also been associated with cancer risk. Alterations in DNA damage repair and te

MAP3K6 Mutations in a Neurovascular Disease Causing Stroke, Cognitive Impairment, and Tremor

Objective: To describe a possible novel genetic mechanism for cerebral small vessel disease (cSVD) and stroke.Methods: We studied a Swedish kindred with ischemic stroke and intracerebral hemorrhage, tremor, dysautonomia, and mild cognitive decline. Members were examined clinically, radiologically, and by histopathology. Genetic workup included whole-exome sequencing (WES) and whole-genome sequenci

Gender and the Outcome of Postcardiotomy Veno-arterial Extracorporeal Membrane Oxygenation

Objective: There is a paucity of sex-specific data on patients’ postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO). The present study sought to assess this issue in a multicenter study. Design: Retrospective, propensity score–matched analysis of an international registry. Setting: Multicenter study, tertiary university hospitals. Participants: Data on adult patients undergoi

Tailoring plasmonic resonances in Cu-Ag metal islands films

The plasmonic response of Cu-Ag metal islands films is investigated. Films are obtained by subsequent electron beam deposition of Ag and Cu using different fabrication conditions: deposited mass thickness, substrate temperature and post-deposition annealing in vacuum. Optical properties of films are investigated by spectroscopic ellipsometry and correlated with the structural characterization resu

Decoding mechanical cues by molecular mechanotransduction

Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding ma

A framework for evaluating societal safety interventions

Societal safety concerns maintaining critical social functions to protect the life and health of citizens as well as to meet their basic needs in times of crisis. Societal safety interventions are implemented by a range of actors in society. However, systematic evaluations of the suitability and effectiveness of proactive societal safety interventions are rather scarce – especially for complex int

Breathlessness across generations : Results from the RHINESSA generation study

Background: Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations. Methods: We analysed the association between breathlessness in parents and their offspring in the Respirator

Large screen enabled tri-port MIMO handset antenna for low LTE bands

In recent years, the screen-to-body ratio of mobile handsets has been increasing. Today, the screen nearly fills up the entire front side. Conventionally, the screen is mainly seen as a metallic object that adversely affects antenna performance. In this paper, the large screen is used for the first time to facilitate an additional uncorrelated MIMO port in a tri-port design, for several LTE bands