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Disease predisposing germline mutations in cancer susceptibility genes may consist of large genomic rearrangements, including deletions or duplications that are challenging, to detect and characterize using standard PCR-based mutation screening methods. Such rearrangements range from single exons up to hundreds of kilobases of sequence in size. Array-based comparative genomic hybridization (aCGH)
In 1553-1554 one Pieter Bruegel purchased a corrody in Sint-Janshuis, a retirement home for former employees of the Marquises of Bergen, where he would receive necessities of life and a place to stay until he would pass away. The paper reconstructs the early financial history of the retirement home, demonstrating how it was unable to cope with inflation, and struggled to provide for the inmates. I
We present genetIC, a new code for generating initial conditions for cosmological N-body simulations. The code allows precise, user-specified alterations to be made to arbitrary regions of the simulation (while maintaining consistency with the statistical ensemble). These "genetic modifications"allow, for example, the history, mass, or environment of a target halo to be altered in order to study t
Nowadays, many industries are investing a lot of resources in the development of new technologies that interpret hand gestures and use them as a communication interface between the user and the system. However, the surveillance industries have remained on the sidelines of this technological development. Instead, the joystick and the mouse are the most common devices found in control rooms. Using t