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Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and complex disease cluster, and to enhance contemporary evidence-based medicine. Its key pillars are diagnostics; prediction (of the primary disease); prevention (of the primary disease); prognosis (prediction of complications of the primary disease); trea
Objectives: In patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) initiating secukinumab, we aimed to assess and compare the proportion of patients achieving 6-, 12- and 24-month patient-reported outcomes (PRO) remission and the 24-month retention rates. Patients and methods: Patients with axSpA or PsA from 16 European registries, who initiated secukinumab in routine care w
Type-2 diabetes (T2D) worsens stroke recovery, amplifying post-stroke disabilities. Currently, there are no therapies targeting this important clinical problem. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are potent anti-diabetic drugs that also efficiently reduce cardiovascular death and heart failure. In addition, SGLT2i facilitate several processes implicated in stroke recovery. However,
Youth anxiety disorders are common and heterogeneous. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered tool designed to assess overall anxiety severity, independent of specific symptoms. The thresholds on PARS for the reliable change index (RCI), the minimal clinically important difference (MCID), treatment response, and full and partial remission remain unclear. Using the Cli
Insect pollinators are declining globally, partly due to agricultural intensification, which threatens biodiversity and ecosystem services. To help decision-makers make informed choices, a variety of tools such as softwares, websites and frameworks have been developed to guide pollinator-friendly management and conservation. However, the lack of a comprehensive overview of these tools limits stake
Microorganisms are key players in the global cycling of nitrogen and carbon, controlling their availability and fluxes, including the emissions of the powerful greenhouse gases nitrous oxide and methane. Standard sequencing methods often reveal only a limited fraction of their diversity, because of their low relative abundance, the insufficient sequencing depth of traditional metagenomes of comple
The Swedish pulp and paper industry (PPI) accounts for almost 50 percent of industrial final energy use. It is an energy-intensive industry and process optimization is seen as prerequisite to compete on the global market. This alone should motivate company boards and on-site organisations to put energy management high on the agenda. Definitely, from time to time, energy issues (e.g. fuel shifts, s
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cell
Introduction: The CVA24 antigenic variant is the causal agent of epidemics of acute hemorrhagic conjunctivitis that has prevailed to date. To study the transmission dynamics and evolution of this variant, we molecularly characterized Cuban isolates obtained in 5 epidemic periods between 1986 and 2009. Methods: Using the BEAST v1.8.4 program, it was performed the phylogenetic and phylodynamic analy
The concept of autonomous humidity control material (AHCM) is inspired by phase change material. AHCM is a new type of functional sorbent material. It can adsorb/release sufficient water vapor at the target relative humidity level and autonomously maintain the indoor relative humidity at a set value/range without external intervention, which cannot be achieved by conventional sorbents (e.g., zeoli
Since banks provide various forms of credit, they consequently expose the business as well as society to risks. Therefore, global banking regulations exist to ensure that banks keep enough capital for the risks they are taking. One such risk is name credit concentration risk, arising when exposures in a portfolio have a skew distribution across different counterparties. Regarding the treatment of
Several problems concern about energy are frequently discussed in recent decades, such as the shortage of traditional energy resource, the increase of energy price and the destruction of living environment by energy conversion. To solve these problems, sustainable development of energy become a preferential task all around the world. Under current circumstances, applying energy saving measures and
Solar radiation is affected in a variety of different ways through the atmosphere and on its way down to the Earth’s surface. Clouds are the main factor in this attenuation of solar radiation, but aerosols, ozone and other different gases have a significant impact too. Understanding these processes is fundamental to solar forecasting. However, the atmosphere is constantly changing, which makes for
With better understanding of the properties and mechanical behavior of wood fiber composites such as wood particle boards the final structure can be improved, both from a solid mechanical and cost effective perspective. Particle boards are widely used in today’s industry for consumer products and the mechanical properties for such materials and how it is effected by the mix of wood chips and glue
Devastating catastrophes during the 1980s together with recent years’ fatal accidents, including the Boeing 737 MAX plane crashes in 2018 and 2019, have altogether highlighted the need for researchers’ attention within the field of safety-critical systems. Additionally, as a result from technological advancement and globalization, the prevalent complexity and ambiguity within today’s systems conti
As a country with a high proportion of population and land area in the world, China is in a stage of changing its economic development direction, from the previous extensive economic growth to the intensive economic growth. At the same time, due to the limited total amount of resources and limited environmental bearing capacity on the earth, certain constraints are found in terms of amount and str
Mother tongue tuition (MTT) has been part of the Swedish educational system since 1977, with now almost 30 per cent of elementary school students eligible for the subject. With an increasingly globalized world, as well as expectations from the EU of all their member states’ citizens learning at least three languages, MTT could work as a means to meet the goal of a more linguistically knowledgeable
Due to the world’s growing population and an increase in food demand, new innovative food products need to be developed to maximize the use of limited farmland. Because of global warming and the fact that plant based products generate less greenhouse gases than meat based products, research should focus on new plant-based protein sources. Rapeseed press cake is a residue from rapeseed oil producti
Car sharing (CS) is a growing phenomenon globally but its environmental implications are not yet fully explored. While many researchers agree that it could have multiple direct environmental benefits, indirect effects like carbon emissions induced through changed consumption patterns have been poorly explored. This thesis aims to quantify and compare consumption induced carbon emissions (CCE) of C
