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What takes place during the monitoring cycles of UN treaty bodies, and what impact do these cycles have both locally and globally? Movement in the Rights Direction explores these questions through the lens of the UN Human Rights Committee, the treaty body responsible for overseeing state compliance with the International Covenant on Civil and Political Rights (ICCPR), often considered the UN’s mos
Background and ObjectivesThe number of older adults living alone is increasing globally, often with varied risks and resilience capacities. Digital technologies may help mitigate these risks, but their potential remains poorly understood. This review maps evidence on digital technologies in social and health care interventions for older adults living alone, focusing on technology types, functions,
In Europe, 6,000 young people die of cancer yearly, the commonest disease causing death beyond the age of 1 year. In addition, 300,000-500,000 European citizens are survivors of a childhood cancer and up to 30% of them have severe long-term sequelae of their treatment. Increasing both cure and quality of cure are the two goals of the European paediatric haematology/oncology community. SIOPE coordi
An integrated study of palynology, Mossbauer spectroscopy, mineralogy and osmium isotopes has led to the detection of the first K-Pg boundary clay layer in a Southern Hemisphere terrestrial setting. The K-Pg boundary layer was independently identified at centimetre resolution by all the above mentioned methods at the marine K-Pg boundary site of mid-Waipara and the terrestrial site of Compressor C
Background and aimImproving the quality of health care is a global priority, yet many conventional quality improvement approaches, rooted in industrial models of standardisation and control, struggle to account for the uncertainty and complexity of clinical care. Trauma, defined as external injury and the body's physiological response, causes about 4.4 million deaths each year. The impact is great
Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia
The aim of Task 4.1 is to derive emission factors based on bottom-up land surface modelling, using two process-based dynamic global vegetation models (DGVMs), LPJ-GUESS and ORCHIDEE. In recent years, emission factors have been proposed as a useful methodology for estimating greenhouse gas emissions under different land-management strategies. Whilst emission factors are straightforward to implement
High fidelity Large Eddy Simulations (LES) are performed on a non-premixed hydrogen-air annular rotating detonation combustor. The simulations utilize a 22-step hydrogen-air reaction mechanism and an existing flow solver that is optimized for high-speed reacting flows. The selected combustor, designed by the US Air Force Research Laboratory (AFRL), has been extensively studied experimentally acros
Cardiac rehabilitation (CR) is a well established intervention for secondary prevention after myocardial infarction (MI), yet substantial variability in CR delivery and patient outcomes persists globally. This review provides an in-depth overview of the SWEDEHEART-CR registry, a comprehensive Swedish national quality registry that has facilitated continuous quality improvement and clinical researc
B cell lymphomas (BCLs) are a group of severe cancers, afflicting both men and women at different ages. Gene expression profiling (GEP), have during the latest decades fundamentally contributed to a better classification and biological understanding of the different BCLs. Most studies using GEP have analyzed mRNA from tumor tissue constituted of both tumor cells and non-malignant bystander cells.
A large empirical literature relates corporate ESG performance to corporate financial performance, but the bulk of the evidence is drawn from return on assets and market value measures rather than from operating margin, and most studies estimate a single coefficient pooled across industries. This thesis examines whether year-over-year changes in ESG score are associated with subsequent operating p
Hepatic encephalopathy (HE) is a frequent and debilitating complication of cirrhosis and its pathogenesis is not definitively clarified. Recent hypotheses focus on the possible existence of low-grade cerebral edema due to accumulation of osmolytes secondary to hyperammonemia. In the present study we investigated increases in cerebral water content by a novel magnetic resonance impedance (MRI) tech
Sustainable development is a global priority, but it is particularly urgent for developing and emerging economies, which must reconcile continued economic expansion with increasing environmental pressures. One region grappling with this challenge is Latin America and the Caribbean, where countries have limited, credible policies in pursuing sustainable economic growth. This paper, therefore, focus
Popular Abstract in Swedish Septisk shock (shock utlöst av blodförgiftning) är en potentiellt dödlig komplikation till infektion med bakterier eller andra mikroorganismer. Inte bara de infekterande organismerna i sig, men också de inflammatoriska system och signalsubstanser som aktiveras, orsaker ett generaliserat inflammatoriskt tillstånd. Om obehandlat, kan detta leda till att ett eller flera orNitric oxide (NO) is important in the control of blood pressure and organ perfusion. In septic shock, NO produced by inducible NO-synthase (NOS) has been claimed to mediate pathological vasodilation and cell injury, while NO produced by constitutive NOS may be protective in counteracting hypoperfusion and organ injury. This thesis comprises studies on the effects of inhaled NO on pulmonary functio
Perinatal asphyxia with hypoxic ischemic encephalopathy (HIE) is the most important cause of perinatal mortality and cerebral palsy (CP) in infants born at term. The aim of the thesis was to investigate epidemiology of perinatal asphyxia, and to investigate early clinical neurological symptoms after perinatal asphyxia in relation to cerebral glucose metabolism (CMRgl) measured by 18-FDG-PET, neuro
In this work, a method for registration of whole-body (WB) scintillation-camera images is presented. The primary motive for the development is to perform activity quantification using the conjugate view method on an image basis. Accurate image registration is required for sequential anterior and posterior scans, for serial emission images for analysis of the biokinetics, and for transmission and e
BACKGROUND: The long-term survival of patients with advanced stage aggressive lymphoma has not improved significantly during the last twenty years. In a randomised trial, the efficacy of MACOP-B, a six-drug weekly chemotherapy regimen, was compared to CHOP, the current standard regimen, in terms of overall and failure-free survival, toxicity and health related quality of life. PATIENTS AND METHODS
