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BackgroundAdvanced Trauma Life Support® (ATLS®) is the most widely adopted form of trauma life support training worldwide, but there is no high-quality evidence that it can improve patient outcomes. The aim of this trial is to compare the effects of ATLS® training with standard care on outcomes in adult trauma patients.MethodsADVANCE TRAUMA is a batched stepped-wedge cluster randomised controlled
Currently, both the US and the EU are pursuing industrial policies to support climate mitigation objectives. The climate transition will require increased use of material resources, but the envisioned industrial policies do not sufficiently address resource use, despite the current unsustainable global resource-use trajectory. The lack of industrial policy in this field is therefore relevant and t
Objective: Powered mobility offers young children the opportunity to explore their world, develop awareness of their environment, and actively participate in play and daily activities. It enables children with severe disabilities to experience equity and equality by increasing their mobility. Powered mobility devices not only provide means for movement but also enhance children's understanding of
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and can lead to hepatocellular carcinoma (HCC), a leading cause of cancer-related death. We aimed to determine the extent to which MASLD is an increasing cause of HCC in Sweden and to determine clinical characteristics associated with underlying MASLD. Using the Swedish quality re
The oxy-fuel combustion of coke oven gas generates CH4/H2/O2/CO2 mixtures, and this study focuses on measuring the laminar burning velocities of these mixtures which are rarely studied previously. The investigation encompasses a range of equivalence ratios from 0.6 to 1.5, O2/(O2 + CO2) ratios varying between 0.25 and 0.38, and H2/(H2 + CH4) ratios ranging from 0.25 to 0.6, under normal temperatur
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer’s disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is unclear. In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal d
Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities
Hydrogen energy technologies are forecasted to play a critical supporting role in global decarbonisation efforts, as reflected by the growth of national hydrogen energy strategies in recent years. Notably, the UK government published its Hydrogen Strategy in August 2021 to support decarbonisation targets and energy security ambitions. While establishing techno-economic feasibility for hydrogen ene
Decarbonising the global housing stock is imperative for reaching climate change targets. In the United Kingdom, hydrogen is currently being tested as a replacement fuel for natural gas, which could be used to supply low-carbon energy to parts of the country. Transitioning the residential sector towards a net-zero future will call for an inclusive understanding of consumer preferences for emerging
In an era characterised by political instability, economic uncertainty and mounting environmental pressures, hydrogen fuel is being positioned as a critical piece of the global energy security and clean energy agenda. The policy push is noteworthy in the United Kingdom, where the government is targeting industrial decarbonisation via hydrogen, while exploring a potential role for hydrogen-fuelled
Conservation genomics is a rapidly growing subdiscipline of conservation biology that uses genome-wide information to inform management of biodiversity at all levels. Such efforts typically focus on species or systems of conservation interest, but rarely consider associated microbes. At least three major approaches have been used to study how microorganisms broadly contribute to conservation areas
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t
Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i
Interconnected societal challenges such as climate change, biodiversity loss and food security demand immediate and coordinated action across local to global scales, guided by coherent policies and management mechanisms. Reflecting on the critical need to address societal challenges, Nature-based Solutions in marine and coastal environments, known as blue NBS, have emerged as an important part of
This study aims to compare and validate two soil-vegetation-atmosphere-transfer (SVAT) schemes: TERRA-ML and the Community Land Model (CLM). Both SVAT schemes are run in standalone mode (decoupled from an atmospheric model) and forced with meteorological in-situ measurements obtained at several tropical African sites. Model performance is quantified by comparing simulated sensible and latent heat
The effect of future climate scenarios on surface and groundwater resources was simulated using a model- ing approach for an artificial recharge area in arid southern Iran. Future climate data for the periods of 2010–2030 and 2030–2050 were acquired from the Canadian Global Coupled Model (CGCM 3.1) for scenarios A1B, A2, and B1. These scenarios were adapted to the studied region us- ing the delta-
Here we present the integrated design, high-fidelity simulation, and virtual emissioncertification of a medium-range aero-engine combustor developed within the EU-funded MYTHOS project. The objective is to establish a physics-based framework capable of predicting combustor behavior for both conventional fuels and emerging Sustainable Aviation Fuels (SAF). Starting from a 0D thermodynamic cycle, a
This study examines the contribution of a structural glass window integrated into a lightweight timber-frame wall diaphragm at the structural level. A full-scale timber mock-up, comprising different bracing elements such as wall diaphragms (with and without a bonded structural window), and a moment-resisting frame, combined with a roof diaphragm, was subjected to multiple serviceability limit stat
Background Physical assistive robots are increasingly promoted in rehabilitation. However, it remains unclear how and for whom, physical assistive robots move from laboratory prototypes into rehabilitation practice, and whether this transition mitigates or reproduces existing inequalities in access to rehabilitation. Objective To examine how moral reasoning and institutional arrangements shape who
