Filetype
Recent multi-stage genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are robustly associated with chronic lymphocytic leukaemia (CLL) risk. Given that most of these SNPs map to non-coding regions of the genome, it suggests that the functional basis of many GWAS signals will be through differential gene expression. By referencing publically accessibl
Project management office (PMO) maturity models are widely used to assess PMO capability and guide organisational improvement initiatives. However, their ability to capture PMO performance and value delivery remains uncertain, particularly in complex industrial environments where organisational context strongly shapes project work. This study enhances understanding of the extent to which the PMO M
Using hydrodynamical simulations of entire galactic discs similar to the Milky Way (MW), reaching 4.6 pc resolution, we study the origins of observed physical properties of giant molecular clouds (GMCs). We find that efficient stellar feedback is a necessary ingredient in order to develop a realistic interstellar medium, leading to molecular cloud masses, sizes, velocity dispersions, and virial pa
Swedish municipalities have traditionally had significant powers and played a major role in implementing national energy strategies. This paper describes the factors influencing development of municipal climate and energy plans in five Swedish municipalities and assesses the relevance and importance of these factors from theoretical and practical perspectives. The questions raised in the paper are
Central Asia is a key area to study the impact of Cenozoic climate cooling on continental ecosystems. One of the best places to search for rather continuous paleontological records is the Valley of Lakes in Mongolia with its outstandingly fossil-rich Oligocene and Miocene terrestrial sediments. Here, we investigate the response by mammal communities during the early stage of Earth's icehouse clima
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32. In a bivariate analysis combining the nevus results with a recent mela
This paper considers the problem of recovering either a low rank matrix or a sparse vector from observations of linear combinations of the vector or matrix elements. Recent methods replace the non-convex regularization with ℓ1 or nuclear norm relaxations. It is well known that this approach recovers near optimal solutions if a so called restricted isometry property (RIP) holds. On the other hand i
The most abundant plasma protein, human serum albumin (HSA), is known to undergo several conformational transitions in an acidic environment. To avoid buffer effects and correlate global and local structural changes, we developed a continuous acidification method and simultaneously monitored the protein changes by both small-angle scattering (SAXS) and fluorescence. The progressive acidification,
We are seeing today an increased interest in ethics, the environment, and social responsibility at the same time as the individual is expected, in different ways, to realize him-/herself through consumption. These interests coincide with the establishment of ethical markets for re-use and second-hand. In this paper we investigate and map out the ethical shopping spaces in Helsingborg, and how thes
Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of application of this therapeutic approach are warranted. To this end, we have investigated the possibility of improving the response of BRCA1 mutant breast cancer cells to PARP1 inhibition by co-targeting the PI3K
We present a new methodology involving the simultaneous refinement of both x-ray absorption and x-ray diffraction spectra (x-ray absorption/diffraction structural refinement, XADSR) to study the hydration and ion pair structure of CaCl2 and RbBr salts in concentrated aqueous solutions. The XADSR method combines the x-ray absorption fine structure (XAFS) spectral analysis of both the cation and ani
Climate change research is at an impasse. The transformation of economies and everyday practices is more urgent, and yet appears ever more daunting as attempts at behaviour change, regulations, and global agreements confront material and social-political infrastructures that support the status quo. Effective action requires new ways of conceptualizing society, climate and environment and yet curre
One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. In some destinations, e.g. Barcelona, the pressure from tourism on local resources such as housing and urban space has reached a point where we begin to speak about overtourism. The development of overtourism is related to decreasing relative costs of travel, e.g. low-
A sound pedagogical framework must be explored and identified to implement opportunities for collaborative learning through international exchange. This paper identifies the framework used by two universities, in Sweden and the United States. Virtual learning environments and meaningful learning activities can be constructed using web-based learning platforms. The goal for this initiative was 'int
Folk music programmes have been a major feature of higher education music departments across the Nordic region for several decades. Still, programmes that offer the opportunity to deeply study non-European music (other than jazz) are very rare in most of Europe, and programmes in music education that offer such opportunities at anything more than a superficial level had been virtually non-existent
Heat stress at the workplace is an occupational health hazard that reduces labour productivity(1). Assessment of productivity loss resulting from climate change has so far been based on physiological models of heat exposure(1). These models suggest productivity may decrease by 11-27% by 2080 in hot regions such as Asia and the Caribbean(2), and globally by up to 20% in hot months by 2050(3). Using
The increased availability of digital spatial data combined with improved capabilities of Geographic Information Systems (GIS) have allowed for the development of several global population distribution databases, such as the GPW, and LandScan. Making population distribution data available as a high-resolution raster database which facilitates rapid GIS analysis at the local level and for any zo
The many factors of today’s society strongly influence individuals regarding what to consume and how to behave. The information technology causes a rapid transformation of the society that, together with globalization, results in increased competition. Companies do not have time to analyze all that occurs around them. Consequently, there is a demand for a specialized competence within this field,
