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Introduction Lynch syndrome (LS) carriers have a 20-46% lifetime risk of colorectal cancer (CRC) due to mismatch repair gene variants. Mesalamine (5-ASA, 5-aminosalicylic acid), used safely in patients with ulcerative colitis, may reduce CRC risk in LS by decreasing microsatellite instability, a key driver of LS-related cancer. This study evaluates 5-ASA's efficacy as a tolerable chemopreventive d
Ever-increasing global water shortages necessitate more advanced and cost-effective water purification methods. Herein, a novel slow filtration system using natural raw zeolite is proposed as an alternative to traditional quartz sand as a filter medium. The system demonstrates excellent performance in reducing turbidity and removing methylene blue (MB). The natural zeolite-based filtration system
Wind energy is an increasingly viable solution for sustainable power generation, particularly in developing regions with high wind potential. This paper presents a comprehensive analysis of the wind power and energy output estimation for the Sela Dingay wind farm, a candidate site in Ethiopia. The study utilizes measured wind speed data at 50 meters and interpolates it to different hub heights (91
Importance Longitudinal data are crucial for understanding rapid population aging in East and Southeast Asia, yet challenges in establishing and managing infrastructures remain undocumented.Objective To investigate challenges and adaptations across longitudinal aging datasets in East and Southeast Asia and synthesize stakeholder-informed processes and recommendations to guide future study design
Rapid and deep energy system decarbonisation is essential to a safe future. Thermal energy storage may hold the key to significant carbon reduction of the heating, cooling and electricity sectors, but the UK remains largely locked in to a fossil-fuel based heating regime. Global urbanisation trends mean cities are crucial to the net-zero transition. This thesis provides a sociotechnical analysis o
Brazil maintains its position at the top of the global ranking of plastic producers, yet recycling efforts have been incipient. Recent data reveals an annual production of approximately 14 million tons of plastic waste, not accounting for the surge in the usage of plastic masks and related materials due to the COVID-19 pandemic. However, what remains largely unreported is that over half of post-co
For more than two decades, Iran’s nuclear program has been a central focus of Europe’s engagement with Iran. Presently, with the virtual collapse of the Iran nuclearagreement (JCPOA) and Iran’s support for Russia in the war against Ukraine—coupled with the repercussions of the Mahsa Amini protests and the war in Gaza— Europe’s relations with Iran are deteriorating as Iran’s interests in Europe are
Objective: To study the impact of tumour necrosis factor-α inhibitor (TNFi) therapy on the use of non-steroidal anti inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) in Iceland. Method: This registry cohort study used data from the nationwide database on biologics in Iceland (ICEBIO) and the Icelandic Prescriptio
Selective serotonin reuptake inhibitors (SSRIs) have shown promise in cancer therapy, particularly for hepatocellular carcinoma (HCC), but their molecular targets and mechanisms remain unclear. Here, we show that SSRIs exhibit significant anti-HCC effects independent of their classical target, the serotonin reuptake transporter (SERT). Using global inverse gene expression profiling, drug affinity
Purpose: We aimed to analyze the risk of hereditary hemochromatosis (HH) among first-generation and second-generation immigrants in Sweden using Swedish-born individuals and Swedish-born individuals with Swedish-born parents as referents, respectively. Methods: All individuals aged 18 years of age and older, n = 6,180,500 in the first-generation study, and n = 4,589,930 in the second-generation st
This paper presents an approximation model for optimizing reorder points in one-warehouse N-retailer inventory systems subject to highly variable lumpy demand. The motivation for this work stems from close cooperation with a supply chain management software company, Syncron International, and one of their customers, a global spare parts provider. The model heuristically coordinates the inventory s
In the mid-nineteenth century, Karl Marx issued several critiques of political economy writings stressing the exclusive duality of states and the national economies. He argued that capitalism had characteristic features quite apart from those shaped by the idiosyncrasies of national economies. In the first part of this article, we critique the contemporary state-centered explanations for the indus
BACKGROUND: -Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death (SCD) and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological dete
We explore how two community-based reform models align with the World Bank's World Development Report 2004 accountability framework. Using a qualitative case study of rural Guatemalan primary schools, we examine local governance through interviews with a range of stakeholders. While both reforms appear appropriate according to the World Bank's accountability framework, especially the model giving
Title: Mobile Social Commerce in China: The interactive role of platforms Date of the seminar: 4 June 2019 Course: BUSN39 Degree Project in Global Marketing Authors: Jiewen Cheng & Svenja Sabrina Tänzer Supervisor: Tommy Shih Keywords: mobile s-commerce platforms, interaction, communication, community, commerce Thesis purpose: This thesis aims to give a better understanding of the intera
Ostreopsis ovata is a benthic dinoflagellate that produces palytoxin and its analogues. Since the end of the 1990s, toxic blooms of O. ovata have been recorded in many tropical and temperate marine waters. These blooms often kill benthic invertebrates and cause health problems for humans. We hypothesize that increases in seawater temperature might induce these blooms. A strain of O. ovata isolated
Information on the spatial distribution of past vegetation on local, regional and global scales is increasingly used within climate modelling, nature conservancy and archaeology. It is possible to obtain such information from fossil pollen records in lakes and bogs using the landscape reconstruction algorithm (LRA) and its two models, REVEALS and LOVE. These models assume that reliable pollen prod
