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Lakes and ponds are habitats of great human importance as they provide water for domestic, industrial and agricultural use as well as providing food. In spite of their fundamental importance to humans, freshwater systems have been severely affected by a multitude of anthropogenic disturbances, which have led to serious negative effects on the structure and function of these ecosystems. The aim of

The purpose of the study was to investigate whether baseline quality of life (QoL) and changes in QoL scores from baseline are prognostic for time to progression (TTP) and/or overall survival (OS) in patients with advanced breast cancer receiving docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). QoL was assessed at baseline and before each treatment using the European Organization

Monoterpenes, primarily emitted by terrestrial vegetation, can influence atmospheric ozone chemistry, and can form precursors for secondary organic aerosol. The short-term emissions of monoterpenes have been well studied and understood, but their long-term variability, which is particularly important for atmospheric chemistry, has not. This understanding is crucial for the understanding of future

Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysi

BACKGROUND: Acute appendicitis is the most common surgical emergency worldwide. Concern that delayed treatment might increase perforation can lead to unnecessary surgery and high rates of negative appendicectomy, where a normal, non-inflamed appendix is removed. However, whether perforation is related to pre-hospital time (symptom onset to first surgical assessment) has not been explored in contem

China's accession to the WTO was perceived as the West integrating the East into the international economy with market economy reforming the planned economy. The major actors, the United States (US) and the Euorpean Union (EU), with similar economic structures and ideologies were expected to cooperate and bargain the best offers from China. However, while the US adopted a confrontational appro

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient-reported outcomes by mobile technology offers the possibility to better understand real-life burden of CRS. Methods: This study reports on the cross-sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application

Agricultural land use results in multiple stressors affecting stream ecosystems. Flow reduction due to water abstraction, elevated levels of nutrients and chemical contaminants are common agricultural stressors worldwide. Concurrently, stream ecosystems are also increasingly affected by climate change. Interactions among multiple co-occurring stressors result in biological responses that cannot be

Agrobiodiversity—the variation within agricultural plants, animals, and practices—is often suggested as a way to mitigate the negative impacts of climate change on crops [S. A. Wood et al., Trends Ecol. Evol. 30, 531–539 (2015)]. Recently, increasing research and attention has focused on exploiting the intraspecific genetic variation within a crop [Hajjar et al., Agric. Ecosyst. Environ. 123, 261–

Background: Non-motor symptoms are present in Parkinson's disease (PD) and a key determinant of quality of life. The Non-motor Symptoms Scale (NMSS) is a validated scale that allows quantifying frequency and severity (burden) of NMS. We report a proposal for using NMSS scores to determine levels of NMS burden (NMSB) and to complete PD patient classification. Methods: This was an observational, cro

Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current, w

Bolivia holds among the biggest reserves of lithium in the world. Lithium-ion batteries are essential components in electric vehicles, solar panels, and wind turbines, and are therefore crucial for a global transition from fossil fuels to renewable energy. Meanwhile, the extraction process of lithium can cause large environmental damage. Bolivia has previously failed to industrialize its lithium,

The EU has for a long time been a credible member in the WTO, wherein trade partners need to comply with the EU´s regulations in order to import goods to the Single market. However, trade issues may arise from technical regulations, which could constitute non-tariff trade barriers. In the WTOs Committee on Technical Barriers to Trade, members raise such issues, in order to facilitate trade. Since

Northern peatlands, spanning across vast regions of the northern hemisphere, are critical carbon reservoirs essential for global carbon cycling and climate regulation. Their dual role as long-term atmospheric carbon dioxide (CO2) sinks and the largest natural source of methane (CH4) in the northern hemisphere allows them to accumulate more carbon than they emit, helping to mitigate the rise in atm

Following the discontinuation of LIBOR, the interest rate market has transitioned to backward-looking benchmarks such as SOFR. Unlike traditional forward-looking rates like LIBOR, SOFR is set in arrears, which affects the pricing methods of derivatives linked to these benchmarks. This thesis studies the impact of this transition on the pricing and calibration of caps within the Hull-White framewor