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Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide
Background: Anti-glomerular basement membrane (GBM) nephritis is a rare disease induced by antibodies directed against alpha3(IV)NC1, the Goodpasture antigen. We report a patient with Crohn's disease who developed anti-GBM nephritis and the skin blistering disorder bullous pemphigoid, owing to distinct autoantibodies. Methods: Frozen sections of skin and kidney biopsies were incubated with antiser
The human ribosomal protein S19 gene (RPS19) is mutated in approximately 20% of patients with Diamond-Black fan anemia (DBA), a congenital disease with a specific defect in erythropoiesis. The clinical expression of DBA is highly variable, and subclinical phenotypes may be revealed by elevated erythrocyte deaminase (eADA) activity only. In mice, complete loss of Rps19 results in early embryonic le
Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to
AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabetes. Relative birthweight is associated with HLA genotypes that confer a high risk of diabetes. Our aims were to test whether young children prior to clinical onset of type 1 diabetes have increased: (1) birthweight or birth length standard deviation scores (SDS); (2) height development SDS; or (3) BM
The cholesterol-lowering effect of oats is well established, but the crucial properties eliciting this effect need to be further investigated to optimize the use of oats as functional foods. Furthermore, there are almost no reports investigating the effect of oats on atherosclerosis development. This thesis describes our work with finding suitable mouse models to study cholesterol-lowering and ant
We present spectral hole-burning measurements on the 879 nm, I-4(9/2) -> F-4(3/2) transition in Nd3+ : YVO4. We observe antiholes in the spectrum along with long lived spectral holes, which demonstrates optical pumping between the ground state Zeeman levels. The spectral holes are narrow (homogeneous linewidth of 63 kHz) at 2.1 K with a 300 mT applied magnetic field. We also perform preliminary sp
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magn
Abstract in UndeterminedAn analysis of the environmental effects and resource consumption by four systems for management of wastewater and organic household waste in a new city area have been performed, as follows: (1) conventional system complemented with advanced sludge treatment for phosphorus recovery, (2) blackwater system with urine diversion and food waste disposers, (3) blackwater system w
Sammanfattning Den här uppsatsen handlar om bestämmelsen i 5 kap. 5 § Patientdatalagen (2008:355), PDL, som möjliggör för patienten att läsa sin journal via internet. Uppsatsen handlar även om journalens rättsliga status och ramverk, samt om patientens rätt att ta del av sin journal. Det övergripande syftet med uppsatsen är att undersöka hur datoriseringen av hälso- och sjukvården och dess möjligSummary This essay examines the rule in the Swedish Patient Data Act (Patientdatalagen), which says that it is possible to give the patient access to his/her medical record via the Internet. The aim with the essay is to examine whether the computerization of health care in Sweden has had any impact on the patient’s right to information about his/her medical status. By examining this, the essay an
Syftet med denna uppsats är att med hjälp av en fallstudie undersöka den interna kommunikationens betydelse innan och under en NPM förändring implementeras i en offentlig myndighet för att förändringen ska uppnås och slutföras. Detta är en kvalitativ fallstudie gjord på Länsstyrelsen Skåne där vi genomfört tio semistrukturerade intervjuer med nyckelpersoner från myndigheten. Vi har använt oss av
Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan binds growth factors and interacts with various extracellular matrix proteins and cell adhesion molecules. Homozygous mice with a null mutation in the perlecan gene exhibit normal formation of BMs. However, BMs deteriorate in
Bergkross är det främsta materialet för uppbyggnad av vägar idag. Det är ett jungfruligt material som bara ökar i produktion för användning i anläggningssektorn. För att minska användningen och i förlängningen också produktionen av jungfruliga material undersöks mer sekundära ballastmaterial som exempelvis slaggrus för att nå ett cirkulärt flöde. Slaggrus har undersökts utifrån olika aspekter meCrushed stone is the main material for building roads today. It is a virgin material that is only increasing in production for use in the construction sector. To reduce the use of virgin materials, and with it the production, more secondary aggregate materials such as Municipal solid waste incinerated (MSWI) bottom ash are being investigated to achieve a circular flow. MSWI bottom ash has been in
The concept of a circular economy (CE) has gained traction in the EU as a pathway towards sustainability. However, beyond the goal of closing resource loops there is no consensus on the key components of CE. Efforts to triangulate a definition of CE found that it is mainly a model for economic prosperity that aims to reconcile economic growth with sustainability. In 2020, the Swedish government ad
