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Purpose Cholesterol-lowering medication (CLM) has been reported to have a role in preventing breast cancer recurrence. CLM may attenuate signaling through the estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol. The impact of endocrine treatment on cholesterol levels and hypercholesterolemia per se may counteract the intended effect of aromatase inhi

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The Mesoproterozoic Eon [1,600-1,000 million years ago (Ma)] is emerging as a key interval in Earth history, with a unique geochemical history that might have influenced the course of biological evolution on Earth. Indeed, although this time interval is rather poorly understood, recent chromium isotope results suggest that atmospheric oxygen levels were <0.1% of present levels, sufficiently low to

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The oxygen content of Earth's atmosphere has varied greatly through time, progressing from exceptionally low levels before about 2.3 billion years ago, to much higher levels afterward. In the absence of better information, we usually view the progress in Earth's oxygenation as a series of steps followed by periods of relative stasis. In contrast to this view, and as reported here, a dynamic evolut

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PURPOSE: The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs). PATIENTS AND METHODS: Samples from 48 MPNSTs and 10 neurofibromas were collected from 51 patients with (n = 31) or without (n = 20) neurofibromatosis type 1 (NF1). Genome-wide DNA copy number changes were assessed by chromosomal and ar

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A de novo alpha-synuclein A53T (p.Ala53 Th; c.209G > A) mutation has been identified in a Swedish family with autosomal dominant Parkinson's disease (PD). Two affected individuals had early-onset (before 31 and 40 years), severe levodopa-responsive PD with prominent dysphasia, dysarthria, and cognitive decline. Longitudinal clinical follow-up, EEG, SPECT and CSF biomarker examinations suggested an

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Denna studie syftar till att synliggöra erfarenheter och berättelser från barn till exilflyktingar från Abya Yala som flydde till Sverige, under 70–80 talet, och lyfter hur trauman, minnen och politiska arv påverkar barnens liv – även i vuxen ålder. Genom en dekolonial logik och metodologi undersöks även hur storytelling, autohistoria, chicanafeministisk epistemologi och investigacion-acción partiThis study aims to make visible the experiences and stories of children of exiled refugees from Abya Yala who fled to Sweden, during the 70s and 80s, highlighting how trauma, memories, and political legacies affect the lives of the children – even in their adulthood. Through a decolonial logic and methodology, it also explores how storytelling, autohistory, chicana feminist epistemology and invest

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Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w

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Windstorms are considered the main disturbing abiotic agent in European forests. They affect a multiplicity of forest-related dimensions, such as forest ecology, forest operations, geomorphology, economy, and socio-cultural aspects. Due to the complex dynamics set off by windstorms, the design of post-windstorm forest management should be characterized by an interdisciplinary approach able to addr

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Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as

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OBJECTIVE: To investigate the feasibility of synchrotron radiation-based phase contrast enhanced micro-computed tomography (SR-PhC-μCT) for imaging of human meniscus. Quantitative parameters related to fiber orientation and crimping were evaluated as potential markers of tissue degeneration.DESIGN: Human meniscus specimens from 10 deceased donors were prepared using different preparation schemes:

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The aim of our study was to provide population-based data on incidence and prognosis of synchronous peritoneal carcinomatosis and to evaluate predictors for its development. Diagnosed in 1995-2008, 18,738 cases of primary colorectal cancer were included. Predictors of peritoneal carcinomatosis were analysed by multivariable logistic regression analysis. Median survival in months was calculated by

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Uppsatsens syfte var att undersöka hur ICJ influerar internationell rätt som legal normsättare till det internationella samfundet. Frågeställningen var: hur konceptualiseras idén om ICJ och dess värde för det internationella samfundet av FN:s generalförsamling och domarna som dömde i samband med kärnvapensrådgivningen? Primärmaterialet utgjordes av valda sektioner i de åtta resolutionerna från FN:

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Syfte: Att beskriva den expressiva och impressiva språkförmågan hos barn med cochleaimplantat (CI) i förhållande till normalhörande barn i samma ålder, och undersöka samband mellan språkförmågor och daglig CI-användning, talexponering och exekutiva funktioner. Metod: I studien ingick elva barn med CI mellan 3 år, 9 månader och 6 år, 11 månader. Barnens språkförmågor bedömdes med SIR-skalan, Syntax

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Uppsatsens syfte är att fördjupa förståelsen för den svenska lagstiftarens avvägning mellan personlig integritet och de brottsbekämpande myndigheternas behov av datalagring hos telekommunikationsbolag. Den nationella rätten styrs av EU-rätt på det här området och därför ingår i syftet att redogöra för det nationella och EU-rättsliga regelverket rörande dels datalagring av brottsbekämpande skäl, deThis thesis aims at providing an in-depth study of the balancing act made by the Swedish legislator between the rights to privacy and data protection on the one hand, and the retention of data generated in connection with the provision of publicly available electronic communications networks on the other hand. The latter aspect is something that is made in order to ensure that the data are availab

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Studien belyser hur digitaliseringen och framväxten av omnikanaler har skapat ett dynamiskt shoppingbeteende hos generation Y. Vid inköp av kläder rör sig kunder inom generation Y idag mellan flera försäljningskanaler, vilket ökar tillgängligheten till ett större utbud av klädföretag. Syftet med studien är bidra med förståelse för den lojalitetsskapande effekt hos kundgruppen generation Y som kläd

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Titel: Delningsekonomins verktygslåda: En fallstudie om marknadsföringsverktyg på plattformsföretaget Airbnb Universitet: Lunds Universitet, Campus Helsingborg, Institutionen för Service Management Kurs: KSKK01 Service Management: Examensarbete kandidatexamen, 15 hp Författare: Elin Thoft Thorsell och Karolina Kolton Handledare: Malin Zillinger Nyckelord: Delningsekonomi, plattformsföretag, Airbnb

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Vindkraftens utbyggnad kommer leda till att det i framtiden kommer ställas högre krav på nedstyrning av den aktiva effekten i vindkraftsanläggningar. Denna rapport tar upp hur elproduktionen påverkas vid nedstyrning. Det är inte alltid självklart hur en anläggning påverkas då det är faktorer som turbinlayout, vindriktning och vindhastighet som spelar in. För att kunna modellera nedreglering av deThe expansion of wind power will lead to higher demands on downward regulation of active power in wind power plants. This report treats how the production of electricity is affected by downward regulation. It is not trivial how a wind power plant reacts since factors like turbine layout, wind direction and wind speed have an impact. To be able to model downward regulation of the active power the w