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The impacts of weather and climate-related disasters are increasing, and climate change can exacerbate many disasters. Effectively communicating climate risk and integrating science into policy requires scientists and stakeholders to work together. But dialogue between scientists and policymakers can be challenging given the inherently multidimensional nature of the issues at stake when managing c

AIMS: Cardiovascular magnetic resonance (CMR) imaging can measure the myocardial area at risk (AAR), but the technique has received criticism for inadequate validation. CMR commonly depicts an AAR that is wider than the infarct, which in turn would require a lateral perfusion gradient within the AAR. We investigated the presence of a lateral perfusion gradient within the AAR and validated CMR meas

Purpose: The 4-kallikrein panel, commercially available as the 4Kscore™, is a reflex test for prostate cancer early detection that has been extensively validated in multiple international cohorts. It has been suggested that use of such reflex tests be limited to those with prostate specific antigen less than 10 ng/ml and negative digital rectal examination. We aimed to determine the value of the p

Aim: Migrating birds transport their parasites, often over long distances, but little is known about the transfer of these parasites to resident hosts in either the wintering or breeding ranges of the migratory host populations. We investigated the haemosporidian parasite faunas of migratory and resident birds to determine connections among distant parasite faunas, plausibly brought about by migra

IMPORTANCE In age-related macular degeneration (AMD), rare variants in the complement system have been described, but their functional consequences remain largely unexplored. OBJECTIVES To identify new rare variants in complement genes and determine the functional effect of identified variants on complement levels and complement regulation in serum samples from carriers and noncarriers. DESIGN, SE

The p73 locus gene has a complex structure encoding a plethora of isoforms. The different DeltaN truncated isoforms of p73 may exert different activities depending on the cellular context. The beta isoform of DeltaNp73 seems to have a particular pattern of action even if its role in cell cycle and mitosis is still under investigation. To gain further knowledge of DeltaNp73beta's function, we inves

Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was su

Fetal mesencephalic mouse tissue, rich in dopamine neurons, was xenografted as a dissociated cell suspension into the striatum of rats with unilateral 6-hydroxydopamine induced lesions of the mesostriatal pathway. The rats were either assigned to a 10-day, 21-day or 42-day Cyclosporin A (CyA) immunosuppression scheme, or given no immunosuppression. The functional effects of the grafts were followe

The FinEstBeaMS beamline is under construction at the 1.5 GeV storage ring of the MAX IV Laboratory at Lund, Sweden. It has been designed to cover an unusually wide energy range from ultraviolet (4.3 eV) to soft X-rays (1000 eV) but experiments will also be possible at the Mg and Al Kα energies. Instead of having two different insertion devices and optical schemes for low and high photon energy re

Purpose Cholesterol-lowering medication (CLM) has been reported to have a role in preventing breast cancer recurrence. CLM may attenuate signaling through the estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol. The impact of endocrine treatment on cholesterol levels and hypercholesterolemia per se may counteract the intended effect of aromatase inhi

The Mesoproterozoic Eon [1,600-1,000 million years ago (Ma)] is emerging as a key interval in Earth history, with a unique geochemical history that might have influenced the course of biological evolution on Earth. Indeed, although this time interval is rather poorly understood, recent chromium isotope results suggest that atmospheric oxygen levels were <0.1% of present levels, sufficiently low to

The oxygen content of Earth's atmosphere has varied greatly through time, progressing from exceptionally low levels before about 2.3 billion years ago, to much higher levels afterward. In the absence of better information, we usually view the progress in Earth's oxygenation as a series of steps followed by periods of relative stasis. In contrast to this view, and as reported here, a dynamic evolut

Vårt syfte är att konkretisera och analysera vad introduktionen av utsläppsrätter kommer att innebära och belysa de eventuella oklarheter som kan uppstå inför introduktionen av utsläppsrätter.För att uppfylla vårt syfte har vi valt att genomföra intervjuer med redovisningsspecialister, auktoriserade revisorer, sakkunniga vid Naturvårdsverket samt tre olika fallföretag. Vi har genomfört intervjuer

Företag: Ericsson Mobile Platforms, itAssign, Intentia, BioInvent och Cell Network. Syfte: Syftet med denna uppsats är att beskriva och analysera hur fem företag agerar för att utveckla den kompetens som finns i företaget och på vilket sätt detta agerande visas i den externa redovisningen. Metod: Insamlingen av data har skett genom personliga intervjuer med nyckelpersoner för kompetens i fem föret

Med elektrisk utrustning finns alltid risken att strömförsörjningen fallerar och på så vis sätter utrustningen ur spel. I fallet med övervakningskameror leder detta till att bildströmmen från kameran bryts och det som är satt under bevakning lämnas obevakat. Detta kan potentiellt få allvarliga konsekvenser om det är viktigt att övervakningen är oavbruten. En lösning är att förse utrustningen med n

Denna studie syftar till att synliggöra erfarenheter och berättelser från barn till exilflyktingar från Abya Yala som flydde till Sverige, under 70–80 talet, och lyfter hur trauman, minnen och politiska arv påverkar barnens liv – även i vuxen ålder. Genom en dekolonial logik och metodologi undersöks även hur storytelling, autohistoria, chicanafeministisk epistemologi och investigacion-acción partiThis study aims to make visible the experiences and stories of children of exiled refugees from Abya Yala who fled to Sweden, during the 70s and 80s, highlighting how trauma, memories, and political legacies affect the lives of the children – even in their adulthood. Through a decolonial logic and methodology, it also explores how storytelling, autohistory, chicana feminist epistemology and invest