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Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children within 12 months prior to the appearance of type 1 diabetes-linked islet autoantibodies
In 10 hyperthyroid women studied in the follicular phase of the menstrual cycle, basal plasma PRL was normal, but PRL release after TRH was significantly suppressed compared with that in 11 control women. The suppressed PRL response to TRH was not explained by changes in serum estradiol or sex hormone-binding globulin. It recovered after treatment of hyperthyroidism. When normal women were treated
This article is a response to Steven Enderlein on the translation of Rom 3:23 and its implications for the πίστις Χριστοῦ debate. While affirming Enderlein's suggestion that the verb ὑστερέω is better understood as “lack” rather than “fall short,” we argue against his conclusions (1) that this translation leads to a subjective genitive reading of πίστις Χριστοῦ in Rom 3:22, 26; and (2) that the ve
BACKGROUND: Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units.METHODS: Seven-day inception cohort study in 43 intensive care units in Scandinavia. Patients ≥ 15 years old receiving more than 4
OBJECTIVES: To correlate femoral neck Hounsfield units (HUs) measured on a computed tomography (CT) scan to dual-energy x-ray absorptiometry (DEXA) T-scores allowing evaluation of bone mineral density (BMD) over time after lower extremity trauma-related amputation.DESIGN: Retrospective cohort study.SETTING: United States military trauma referral center.PATIENTS: Military combat-related lower extre
This paper is based on the session ‘Ecosystem services: a useful concept for soil policy making?’ at the Wageningen Applied Soil Conference in September 2011. In that session it was shown from different angles that policy awareness of the dependence of humankind on ecosystem services has resulted in the development of tools for optimal allocation and quantification of ecosystem services and raisin
BACKGROUND: Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we hypothesize that biomechanical factors alone can explain changes in myocardial volume and chamber size in valve disease.METHODS: A validated model of the human vasculature and the f
The gun test stand from MAX-Lab has been upgraded and moved to a new facility at the MAX IV Laboratory. The new test stand will reuse parts of the equipment from the old test stand but a number of improvements to the setup are be made. In this paper we report on the design of the new gun test stand, research plans in the near future as well as planned and possible future research topics..
Objectives To create reference values representative of normal findings on two-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVS) examination of the cervix from 17 to 41 weeks' gestation and to determine the agreement between cervical measurements taken by 2D and 3D TVS. Methods Cross-sectional study covering 17 to 41 weeks in 419 nulliparous and 360 parous women who deliver
BACKGROUND: Internalizing problems have increased among Swedish adolescents. We examined whether classroom disorder was associated with internalizing problems and whether it explained the trends in internalizing problems. Furthermore, we examined whether school contextual factors were associated with internalizing problems and whether they moderated the association between classroom disorder and i
AIMS: Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We investigated the role of IRF5 in human atherosclerosis and plaque stability.METHODS AND RESULTS: Bulk RNA sequencing from the Carotid Plaque Imaging Project biobank were used to mine associations between major macrophage assoc
Currently, the Free electron laser user facility FLASH at DESY is undergoing a significant upgrade involving the complete transformation of one of its beamlines to allow external seeding. With the Echo-Enabled Harmonic Generation (EEHG) seeding method, we aim for the generation of fully coherent XUV and soft X-ray pulses at wavelengths down to 4 nm. The generated FEL radiation is sensitive to vari
The complex deglacial to Holocene oceanographic development in the Gulf of Guayaquil (Eastern Equatorial Pacific) is reconstructed for sea surface and subsurface ocean levels from (isotope) geochemical proxies based on marine sediment cores. At sea surface, southern sourced Cold Coastal Water and tropical Equatorial Surface Water/Tropical Surface Water are intimately related. In particular since ∼
The notion of 'affect' have long been a key concept in the study of fandom, and the term has been used to explicate fandom "affective investments" (Grossberg 1992), "affective play" (Hills 2001) and "affective space" (Lamerichs 2014). The turn, in recent years, to ethnographic study within fandom-studies has led to increasing discussion on researcher/field issues; specifically on self-reflexivity
Technological advances have made diagnosis of heart rhythm disturbances much easier, with a wide variety of options, including single-lead portable devices, smartphones/watches to sophisticated implantable cardiac monitors, allowing accurate data to be collected over different time periods depending on symptoms frequency. This review provides an overview of the novel and existing heart rhythm test
BACKGROUND: Galectins, a family of small carbohydrate binding proteins, have been implicated in regulation of inflammatory reactions, including asthma and fibrosis in the lungs. Galectins are found in cells of the airways and in airway secretions, but their glycoprotein ligands there have only been studied to a very limited extent. METHODS: Bronchoalveolar lavage (BAL) fluid from mild asthmatics a
Papillon-Lefevre syndrome (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial defense. Despite serine protease-deficient immune cell populations, PLS patients do not exhibit marked immunodeficiency. Here, we characterized a 24-year-old woman who had suffered from severe juvenile peri
The interaction of parameters determining the potential emissions of two different mechanically-biologically pretreated municipal solid wastes (MBT wastes) is elucidated in this work. The origins of the wastes are Germany and Sweden. By means of lab-scale experiments, increased stabilisation through composting is preferably determined by a decrease in respiration activity. Concurrently, the stabil
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase and found it to methylate a si
