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Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of the DNA base cytosine by DNA methyltransferases (DNMTs) is an important epigenetic factor regulating gene
Abstract in UndeterminedLimb-girdle muscular dystrophy type 2A is an autosomal recessive disorder generated by inactivating mutations in the gene coding for the muscle specific protease calpain-3. It is mainly expressed in skeletal muscle as a monomeric multidomain protein characterized by three unique insertion sequences (NS, IS1, IS2). It is unstable, and undergoes very rapid autolysis in soluti
Under an artificial light: dark cycle, females of Lampronia capitella were observed calling, with extended terminal abdominal segments, during the first 2 hr of the photoperiod. Extracts of terminal abdominal segments from females elicited large electroantennographic responses from male antennae. Gas chromatography with electroantennographic detection revealed three active peaks. Based on comparis
Different factors influencing recycling and burial rates of organic carbon (OC) were investigated in the continental margin sediments of the Skagerrak (NE North Sea). Two different areas, one in the southern and one in the northeastern part of the Skagerrak were visited shortly after a spring bloom (March 1999) and in late summer (August 2000). Results suggested that: (1) Organic carbon oxidation
Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian
The antilipolytic effect of insulin on human abdominal subcutaneous adipose tissue and skeletal muscle during local inhibition of cAMP-phosphodiesterases (PDEs) was investigated in vivo, by combining microdialysis with a euglycaemic, hyperinsulinaemic clamp. During hyperinsulinaemia, the glycerol concentration decreased by 40% in fat and by 33% in muscle. Addition of the selective PDE3-inhibitor a
The physico-chemical aspects of three native Andean starches from Arracacha xanthorriza, Canna edulis and Oxalis tuberosa were investigated. Scanning electron microscopy-investigations showed that granules of A. xanthorriza were the smallest with irregular shape and sizes between 7 and 23 pm, whereas granules of O. tuberosa and C. edulis were both ovally shaped with granular sizes between 20 and 5
Background: To examine whether neighbourhood non-employment is associated with daily smoking after adjustment for individual characteristics, such as employment status. Methods: Cross-sectional study of a simple, random sample of 31,164 women and men aged 25-64, representative of the entire population in Sweden. Data were collected from the years 1993-2000. The individual variables included age, s
We have measured the differential cross section for the gamman-->pi(-)p and gammap-->pi(+)n reactions at theta(c.m.)=90degrees in the photon energy range from 1.1 to 5.5 GeV at Jefferson Lab (JLab). The data at E(gamma)greater than or similar to3.3 GeV exhibit a global scaling behavior for both pi(-) and pi(+) photoproduction, consistent with the constituent counting rule and the existing pi(+) ph
SummaryThe expansion of the European Union during the last 2 yr has resulted in the need for a revision of existing guidelines to further harmonize education and training in the specialty of anaesthesiology throughout the European Union. Although each individual country is responsible for its own training and certification, these guidelines are intended to reflect minimum criteria for specialist t
The Streptococcus pyogenes cysteine protease SpeB (streptococcal pyrogenic exotoxin B) is important for the invasive potential of the bacteria, but its production is down-regulated following systemic infection. This prompted us to investigate if SpeB potentiated the host immune response after systemic spreading. Addition of Spa to human plasma increased plasma-mediated bacterial killing and prolon
Objective To examine the effectiveness of pH analysis of fetal scalp blood compared with lactate analysis in identifying hypoxia in labour to prevent acidaemia at birth. Design Randomised controlled multicentre trial. Setting Labour wards. Participants Women with a singleton pregnancy, cephalic presentation, gestational age >= 34 weeks, and clinical indication for fetal scalp blood sampling. Inter
The purpose of this essay is to make a study of the requirements of 1§ 1 subparagraph LOB is compatible with the ECHR Art. 5.1 (e), if the application is compatible with the ECHR and if the application is affected by the police professional culture. The European Court has set a number of requirements on a national law in three cases that I have examined and assessed LOBs compatibility with. LOB co
Liksom en trädstam uppvisar årsringar som kan användas för att beräkna dess ålder, bildas också tillväxtringar i tänderna hos många djur, även hos dem som regelbundet byter tanduppsättning. Detta fenomen noterades av paleontologen Richard Owen redan i mitten av 1800-talet, men det är först de senaste decennierna som forskningen inom tandersättningscykler hos utdöda djur har tagit fart. Så kalladeThe dentine of teeth from five genera of mosasaurs [i.e., Clidastes, Halisaurus, Dollosaurus (Prognathodon),cf. Platecarpus, and Tylosaurus] and a Mesozoic crocodylian (Aigialosuchus) from the Campanian of the Kristianstad Basin, southernmost Sweden, displays two types of incremental growth lines; i.e., von Ebner’s and, for the first time in extinct animals, Andresen’s lines. These lines are homol
Purpose: The purpose of this thesis is to investigate how a sustainability label on clothing in an e-commerce context affects a company's brand equity. Methodology: The study was based on a quantitative approach where three of Aaker’s (1991) five dimensions of customer-based brand equity were operationalized. Respondents of our online survey were divided into three groups, exposed to differen
Popular Abstract in English Heme is a small red-colored molecule consisting of an iron atom bound to a chemical structure called porphyrin. Heme is essential for many organisms, including humans, because it is a cofactor in a variety of proteins that are needed to sustain metabolism. The probably most famous heme protein is hemoglobin which gives blood its red color. The heme cofactor in hemoglobiHeme proteins form a large and diverse group of proteins which are involved in a variety of biological functions. The heme prosthetic group enables them to carry out redox reactions, transport electrons, bind gaseous molecules, and function as sensors. Despite their importance only little is generally known about heme protein biogenesis. The Gram-positive bacterium Enterococcus faecalis is found i
En sedimentsekvens bestående av totalt elva borrkärnor togs upp med hjälp av en s.k. ryssborr i dödishålan Skuremålagölen i Skuremåla naturreservat i centrala Blekinge. Från denna sekvens undersöktes gölens senglaciala sediment med hjälp av paleoekologiska och stratigrafiska metoder i syfte att undersöka gölens och områdets utveckling under senglacial tid. Vid analyserna av de senglaciala sedimentWith a Russian chamber corer late glacial sediments were obtained from Skuremålagölen, a kettle hole lake in Skuremåla in the province of Blekinge, southeastern Sweden. The sediments were analysed with respect to pollen content, magnetic susceptibility, loss on ignition and a 14C date. The main aim of the analyses was to interpret the development of Skuremålagölen and its surroundings during the L
