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The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly exposed to microbes and their products, overt infection and damage is a rarity. An important componen
Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer. Here, we investigated the pathogenic impact and prognostic significance of WRAP53β in connection with epithelial ovarian cancer and examined the underlying mechanisms. We find that reduced expression of WRAP53β in ovarian tum
Aim: To determine cathelicidin antimicrobial peptide LL37subcellular distribution in cord neutrophils and normal plasma LL37 levels in mothers and neonates, relate them to delivery mode and relevant biochemical markers, including 25-OHvitamin D [25(OH)D] as this molecules increases cathelicidin gene expression. Methods: A total of 115 infants were included, n = 68 with normal delivery and n = 47 w
BACKGROUND: Cellular prion-related protein (PrP(c)) is a cell-surface protein that is ubiquitously expressed in the human body. The multifunctionality of PrP(c), and presence of an exposed cationic and heparin-binding N-terminus, a feature characterizing many antimicrobial peptides, made us hypothesize that PrP(c) could exert antimicrobial activity. METHODOLOGY AND PRINCIPAL FINDINGS: Intact recom
Exacerbations are the key drivers in the costs of chronic obstructive pulmonary disease (COPD). The objective was to examine the costs of COPD exacerbations in relation to differing degrees of severity of exacerbations and of COPD. We identified 202 subjects with COPD, defined according to the BTS and ERS criteria. Exacerbations were divided into mild (self-managed), mild/moderate (telephone conta
Problemformulering: Organisatoriska gränser orsakar i viss mån ett hinder för företags målfokusering; i ett franchiseföretag blir detta problem ännu mer komplext då gränserna tydliggörs i form av skilda ägarförhållanden. Vi vill i denna uppsats undersöka hur franchiseföretag hanterar de problem som uppstår på grund av dessa gränser. Syfte: Syftet med uppsatsen är att öka kunskapen om svårigheter o
Problem: En övergång från kommunal till privat verksamhet innebär att personalen lämnar ett fält med ett synsätt, för ett annat fält med skild kultur och nya intressen. Intressen som skiljer sig åt från den kommunala sektorn i form av attityder, mål, vinst och drivkrafter. Vi vill undersöka vilka krav det ställer på ledarskapet i en privat organisation som ska ta över tidigare kommunalt anställda.
Summary: This is an investigation of Early Holocene water level changes based on the sediments in two bays, Sörevik and Norrevik on Senoren, an island in the Karlskrona archipelago in eastern Blekinge southeastern Sweden. This area has experienced a number of transgressions and regressions since the last deglaciation at approximately 12,600 BP. The history of the Baltic is characterized by many dr
Objectives. To determine the utility of single-stranded conformation polymorphism (SSCP) analysis for mutation screening in the BTK (Bruton's tyrosine kinase) gene, we investigated 56 X-linked agammaglobulinemia (XLA) families. To obtain genotype/ phenotype correlations, predicted protein aberrations were correlated with the clinical course of the disease. Patients. This study included 56 patients
Airborne dust samples from damp (n = 9) and control (n = 9) residences were analyzed for microorganisms (molds and bacteria), bacterial markers (3-hydroxy fatty acids and muramic acid), and adsorbed volatile organic compounds (VOCs). The number of mold species was greater in the damp residences than in the controls (23 vs.18) and nine mold species were found only in damp residences. The levels of
The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype fo
The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more p
Background: Monitoring of the allergen sensitivity of a patient is most important for optimal patient care and a basic prerequisite for immunomodulating treatment. The objective of this study was to investigate how basophil allergen sensitivity can be applied in the monitoring of anti-immunoglobulin E (IgE) treatment. Methods: Basophils from timothy grass pollen allergic patients were, by flow cyt
Objectives: In this work we studied the temporal evolution of changes in the electrocardiogram (ECG) as a consequence of the induced ischemia during prolonged coronary angioplasty, comparing the time course of indexes reflecting depolarization and those reflecting repolarization. Methods: We considered both local (measured at specific points of the ECG) and global (obtained from the Karhunen-Loeve
Syftet med vår magisteruppsats är att undersöka vilken vikt ledning inom hotellbranschen lägger vid att utveckla personalens kompetens. Detta kommer vi att göra genom att kartlägga frontlinjepersonalens upplevelser kring sin kompetensutveckling. Vi valde att tillämpa ett kvantiativt mätinstrument, enkätundersökning, som vi delade ut till samtliga hotell i Helsingborg. Uppsatsens teoretiska förankr
PROBLEM: Forskningen säger att inre motivation skapas genom yttre belöning. Men frågan är hur frontpersonalen motiveras. Då restaurantbranschen fortsätter att växa samtidigt som den får anses som outforskad, menar vi att frontpersonalens bakomliggande motivationsfaktorer måste undersökas och kartläggas. SYFTE: Syftet med vår uppsats är att undersöka, diskutera och beskriva frontpersonalens motivat
Problembeskrivning: Behovet av ökad kunskap gällande arbetsmotivation tilltar i tider av förändrade karriärmönster och ombytliga trender. Sveriges arbetsmarknad ser inte längre ser ut som den en gång gjorde. Medarbetare ställer nya och högre krav på såväl privatliv som arbetsgivare. Minskad arbetsgivarlojalitet och motivationsbegreppets komplexitet ger därmed fog för att undersöka ämnet. Tidigare
