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We studied the role of arachidonic acid metabolites, histamine, and 5-HT in airway responses to trimellitic anhydride (TMA) in actively sensitized guinea pigs. Sensitization was produced by two intradermal injections of free TMA (0.1 ml of 0.3% TMA in corn oil). After 21 to 28 days, guinea pigs were anesthetized and challenged with intratracheal instillation of 0.5% TMA conjugated to guinea pig se
In this paper, the authors report the use of liquid-liquid partition chromatography (LLPC) in an aqueous polyethylene glycol (PEG)/dextran two-phase system to compare the surface properties (partition properties) of human antibodies and fragments thereof. The surface properties of all the monoclonal antibodies of different classes and subclasses investigated were within the same broad range as tha
Objective: Explore how clinicians select drug treatment based on symptoms, side effects and patient factors, including patient participation in the process, and the association between these factors and attitudes towards drugs. Method: A cohort of 166 patients initially treated with risperidone was followed with yearly assessments over 5 years. At the end of the study, 101 patients were evaluated
Lysozyme adsorption to charged surfaces was studied by Monte Carlo simulations at different protein concentrations, protein net charges, ionic strengths, and surface charge densities. The lysozyme was represented by a hard sphere with embedded positive and negative surface charges parametrically dependent on the solution pH. A short-range attractive protein-protein potential was included to repres
In mice and man, females prefer males with a major histocompatibility complex (MHC) genotype different to their own. We tested whether this phenomenon also occurs in the Swedish sand lizard (Lacerta agilis). Females in a laboratory experiment preferred to associate with odour samples obtained from more distantly related males at the MHC class 1 loci. Data on free-ranging lizards suggest that assoc
An experimental and theoretical study of PdMn bimetallic systems formed on Pd(100) is presented. It is shown that a flat Mn monolayer can be formed at 90 K. A comparison of calculated Mn 3d density-of-states and experimental valence photoemission and x-ray-absorption results suggests that the monolayer is antiferromagnetic, in line with earlier predictions. A similar comparison for the Pd(100)-Mn-
Trace element interactions can affect the absorption, metabolism, or effects of elements. Also, different elements may derive from the same source. Associations in biological media between element concentrations may indicate such phenomena. A large number of correlations were found between 13 trace elements (Co, Cu, Zn, Se, Rb, Rh, Pd, Cd, W, Pt, Hg, Tl, and Pb) in human blood and/or serum, as inv
Variable temperature photoemission studies in the literature have revealed the presence of a surface state above the Fermi level on clean Ge(001). We present photoemission and low energy electron diffraction results from Ge(001) obtained between 185 and 760 K. Our measurements show a peak above the Fermi level with a maximum intensity at a sample temperature of around 625 K. At higher temperatures
Three types of estrogen receptors (ER) exist in the heart, Esr1, Esr2 and the G protein-coupled estrogen receptor 1, Gper1. However, their relative importance in mediating estrogen protective action is unknown. We found that, in the male mouse ventricle, Gper1 transcripts are three- and seventeen-fold more abundant than Esr1 and Esr2 mRNAs, respectively. Analysis of the three ER knockouts (Esr1-/-
Lactobacillus kunkeei is the most abundant bacterial species in the honey crop and food products of honeybees. The 16S rRNA genes of strains isolated from different bee species are nearly identical in sequence and therefore inadequate as markers for studies of co-evolutionary patterns. Here, we have compared the 1.5 Mb genomes of ten L. kunkeei strains isolated from all recognized Apis species and
Yacon (Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson) is a storage root originally grown in the Andean highlands. The fresh roots are perishable and quickly turn brown during handling and processing. Aiming to prolong shelf-life and to preserve the antioxidant compounds in yacon roots, 3 mm thick yacon slices were dried in a drying cabinet at 40, 50, and 60 degrees C to a moisture conten
Syfte: Syftet är att utveckla en modell för värdering av företag i konkurs och där avsikten är att driva företaget vidare efter genomförd konkurs. Metod: Vår uppsats grundar sig främst på empirin och kan därför sägas ha en induktiv ansats. Vi har använt oss av kvalitativa metoder där vi har intervjuat personer som har god kännedom om företagsvärdering samt nyckelpersoner hos två företag. Företagen
Huvudtes: Hur kan det komma sig att de flesta företag inom besöksnäringen väljer att rekrytera internt? Frågeställning: Inom besöksnäringen är den externa rekryteringen av chefspositioner begränsad: - Varför föredrar företagen inom besöksnäringen att rekrytera internt? Syfte: Syftet med uppsatsen är att undersöka hur och i vilken utsträckning företag i besöksnäringen rekryterar. Vi vill även belys
In Sweden today we have an electric power system which is changing. In context of the set energy- and climate goals the use of the transmission grid has started to adjust with consequences for the underlying sub-transmission grid. The situation is special since these two grids are firmly interconnected to each other, but are run by different companies. E.ON who is the operator of the sub-transmiss
The exclusion for signs that consists exclusively of the shape which gives substantial value to the goods have been a part of trademark law of the EU since the first shared trademark-directive came into force in 1989. Since that day the exclusion, who today can be found in Article 7.1(e) iii TMR and Article 4.1(e) iii, have been forced to take a backseat in comparison to the other to exclusions fo
Pollen analysis was made on a profile from the wetland complex Rolands Hav, Blekinge. The aim of the study was to investigate and document the development of the vegetation. The wetland area of Rolands Hav has developed during more than 10 000 years. The stratigraphy of this area will reveal valuable information about environmental changes during this time. The results of the pollen analysis is pr
Organ transplantation increases risk of non-Hodgkin lymphoma (NHL), but long-term risk and time trends have seldom been evaluated. Immunosuppressive drug load is an important risk determinant, but the details are unclear. We studied NHL risk in a nationwide Swedish cohort of 11 081 graft recipients transplanted 1970-2008. Relative risks (RRs) were estimated within the cohort and versus the general
Chronic pain is a prevalent and debilitating condition, conveying immense human burden. Suffering is caused not only by painful symptoms, but also through psychopathological and detrimental physical consequences, generating enormous societal costs. The current treatment armamentarium often fails to achieve satisfying pain relief; thus, research directed toward elucidating the complex pathophysiolo
