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Announced in this Comment and in collaboration with Nature Medicine is the convening of the Data-Driven Decision Support in Obesity Management Commission, to promote adequate scientific evidence to support obesity management across global populations.
Background: Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pathology. Methods: HS-A (N = 5), ADNC (N = 10), and limited/no pathology (N = 12) cases were compared on postmortem MRI signature
Continuous glucose monitors (CGMs) provide detailed glucose profiles, but their relevance to health outcomes in individuals without diabetes remains unclear. Here we assess time in range (TIR3.9–5.6 and TITR3.9-7.8) and glycaemic variability in individuals (N = 3,634; age 46 ± 12 y; 83% female; BMI 27 ± 6 kg/m²) from PREDICT 1 (NCT03479866), PREDICT 2 (NCT03983733), and PREDICT 3 (NCT04735835) wit
Abstract – There is a growing interest in the genomic and developmental basis of discrete or multimodal phenotypes governed by genetic polymorphisms. Recent research has uncovered the genomic basis of such polymorphisms and their maintenance through balancing selection such as negative frequency-dependent selection (NFDS). Such polymorphisms often originate through structural genomic changes or th
PURPOSE: Deleterious effects from concomitant gradients are amplified at lower field strengths and stronger gradients. We aimed to show the signal errors caused by concomitant gradients across a wide range of hardware configurations and propose corrections that can be applied during experimental design and analysis.THEORY AND METHODS: We derived a compact but accurate expression for concomitant gr
The increasing demand for accessible phosphorus sources, essential for plant growth, is placing growing pressure on both industry and academia. Here, we investigate nanoplatelets as carriers for phosphate species, using Laponite® as a model system for sprayable phosphorus formulations. We examine how phosphate species chain length (1, 2, 3, 14, 60, and 130 monomers) governs dispersion stability an
Sound event localization and detection (SELD) systems using audio recordings from a microphone array rely on spatial cues for determining the location of sound events. As a consequence, the localization performance of such systems is to a large extent determined by the quality of the audio features that are used as inputs to the system. We propose a new feature, based on neural generalized cross-c
Fire behaviour is changing in many regions worldwide. However, nonlinear interactions between fire weather, fuel, land use, management and ignitions have impeded formal attribution of global burned area changes. Here, we demonstrate that climate change increasingly explains regional burned area patterns, using an ensemble of global fire models. The simulations show that climate change increased gl
We present a novel approach to the 3D sound source localization task for distributed ad-hoc microphone arrays by formulating it as a set-to-set regression problem. By training a multi-modal masked autoencoder model that operates on audio recordings and microphone coordinates, we show that such a formulation allows for accurate localization of the sound source, by reconstructing coordinates masked
Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000). We detected five discordant p
Since the last edition of this book (2014), progress has been astonishing in all areas of Natural Language Processing, with recent achievements in Text Generation that spurred a media interest going beyond the traditional academic circles. Text Processing has meanwhile become a mainstream industrial tool that is used, to various extents, by countless companies. As such, a revision of this book was
Language exposure and use (LEU) are widely viewed as key factors in multilingual development, and research highlights the importance of considering not just the frequency and quantity of LEU, but also contextual factors such as when and where a language is used, with whom and why. In this study, we illustrate the complexity of LEU in two contexts (study abroad and migration) by applying sequential
Diderot's Encyclopédie is a reference work from XVIIIth century in Europe that aimed at collecting the knowledge of its era. Wikipedia has the same ambition with a much greater scope. However, the lack of digital connection between the two encyclopedias may hinder their comparison and the study of how knowledge has evolved. A key element of Wikipedia is Wikidata that backs the articles with a grap
In modern high energy physics (HEP) experiments, triggers perform the important task of selecting, in real time, the data to be recorded and saved for physics analyses. As a result, trigger strategies play a key role in extracting relevant information from the vast streams of data produced at facilities like the large hadron collider (LHC). As the energy and luminosity of the collisions increase,
Interpolations in the latent space of deep generative models is one of the standard tools to synthesize semantically meaningful mixtures of generated samples. As the generator function is non-linear, commonly used linear interpolations in the latent space do not yield the shortest paths in the sample space, resulting in non-smooth interpolations. Recent work has therefore equipped the latent space
Episodic memory allows the flexible retrieval of commonalities and idiosyncrasies of overlapping life events. For example, seeing a woman in the city with your colleague's daughter may form an integrated memory representation involving the woman and your colleague. However, you may also keep a specific representation of the city event to talk with your colleague about the circumstances of having m
We report on recent developments that enable megahertz hard X-ray phase contrast imaging (MHz XPCI) experiments at the Single Particles, Clusters, and Biomolecules and Serial Femtosecond Crystallography (SPB/SFX) instrument of the European XFEL facility (EuXFEL). We describe the technical implementation of the key components, including an MHz fast camera and a modular indirect X-ray microscope sys
The Eastern Baltic area stands out as a unique location due to the finds of Europe’s youngest dated mammoth remains (12.6–11.2 ka cal BP). Our study explores the drastic climate and landcover changes during the extinction of these gigantic herbivores at the Pleistocene/Holocene boundary. We used macrofossil analysis to determine the major contemporary terrestrial plant genera present in the area a
Contextual shifts are crucial for episodic memory, setting event boundaries during event segmentation. While lab research provides insights, it often lacks the complexity of real-world experiences. We addressed this gap by examining perceptual and conceptual boundaries using virtual reality (VR). Participants acted as salespeople, interacting with customers in a VR environment. Spatial boundaries
