Filetype
Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A
In this article I conceptualise BDSM (Bondage, Domination and Submission, Discipline, Sadism and Masochism) practices within the frame of contemporary intimacies. This article draws from an empirical research in Milan, involving qualitative interviews and participant observations. Initially, I present a definition of BDSM drawn from contemporary sociological and anthropological literature. Then, I
This essay is an analysis of the narrative instance in two novels: Montedidio of the contemporary Italian writer Erri De Luca, published in 2002, and La vie devant soi written by Romain Gary in 1975. The aim of this study is to compare these novels which appear quite similar at first glance: they are both narrated by an autodiegetic narrator, this being a child living in poor social condition. Mor
Popular Abstract in Swedish Ortnamn utgör en särskild del av kulturarvet; under århundraden har de muntligen traderats från generation till generation på den plats där de skapats, där de minner om tidigare händelser, aktiviteter och kunskaper. I synnerhet på de håll skriftlig dokumentation är relativt sentida ger ortnamn en möjlighet att nå insikter om den mer avlägsna historien. Detta gäller särsAs a special part of our cultural heritage, toponyms have been handed down orally from generation to generation for centuries or more at the place where they were coined, recalling events, activities and knowledge. Especially where written documentation is relatively young, place names offer a way to reach further back into the past. This is particularly true of many dialectal cultures, in which o
Our laboratory is focused on understanding host-pathogen interactions, with emphasis on respiratory pathogens, and to use this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection. Our work focuses on both the factors used by bacteria to establish colonization and cause disease and how this is counteracted by host factors in human milk and by the
Our research is focused on the regulation of the complement system in health and disease. Complement is crucial part of innate immunity and thus protects host from infections and contributes to removal of dying cells. We study involvement of complement in pathology of rheumatic and inflammatory diseases as well as several types of cancer. Further, we investigate strategies developed by bacterial
Joint services are responsible for premises and facilities, caretaking and the receptions in the various buildings at LTH. Joint services operate in four of LTHs buildings. In other cases, Departmental Boards have the corresponding responsibilities.
In this group we study the tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D4 (LTD4) and prostaglandins (PGE2) and their respective receptors. These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. Several of the observ
Nuclear medicine is a well-established and increasingly used modality in modern healthcare that generates images for the diagnosis and follow-up of disease. The focus of our research is to optimize nuclear medicine and the research projects covers areas from technical and clinical validation of novel digital positron emission tomography (PET) to automatic quantification of images for prognosticati
Our studies are focused on the revelation of WNT5A, a secreted glycoprotein. WNT5A belongs to the non-transforming class of WNTs, and upon binding to different receptors or co-receptor complexes, it elicits non-canonical (β-catenin-independent) signaling. WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. For example, in breast cancer loss of WNT5A protein is ass
