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Apolipoprotein E (ApoE), a cholesterol transporter and an immunomodulator, is brain protective after experimental stroke and implicated in brain repair. Here, we study the involvement of ApoE in the restoration of brain function after experimental stroke, by using animal housing conditions that differentially improve recovery after occlusion of the middle cerebral artery occlusion (MCAO). We found
Objective: Intranasal immunization with a fusion protein of the ApoB100-derived peptide p210 and the cholera toxin B subunit (CTB-p210) has previously been shown to induce mucosal tolerance and reduce atherosclerosis development, but the exact mode of action remains to be elucidated. Recent studies have indicated an important role for B cells in mucosal tolerance, in particular by induction of reg
This study presents an empirical approach to the use of imperfect and preterite Spanish past tenses, with state and achievement verbs by Swedish students of Spanish as a foreign language in the levels A2, B1 and B2. The main objective is to establish to what extent the participants link the use of the imperfect and the preterite in relation to state and achievement verbs. The study compares the re
ECHOES OF THE OIL SPILL OF 2019: ASSESSMENT OF THE PRESENCE OF PAH AND BTEX IN PRODUCTS FROM FISHING. The 2019 oil spill in Brazil caused widespread contamination in the Brazilian coast, posing risks to both animal and human health through seafood consumption. Therefore, this study aimed to evaluate seafood samples from different locations impacted by the oil spill. For this purpose, 44 samples un
The Rh blood group antigen e is of high incidence and has many epitopes. Partial expression may occur, more commonly in black persons. Individuals with e variant phenotypes can make antibodies to epitopes they lack. While some of these antibodies may be specific for an antigen, e.g., hrB, others, like anti-Rh17 (anti-Hro), show broader specificity, compatible only with D-- and Rhnull red blood cel
The decay of Bacillus subtilis aprE leader-lacZ mRNA was examined in Escherichia coli wild-type and in mutants deficient in RNase E, RNase G, or both. Two versions of the mRNA were studied: the wild-type mRNA, which has a stem-loop at the 5' end, and a mutant mRNA, with a single-stranded 5' end. The half-life of both transcripts was determined by RNase E, the half-life of the mutant transcript bei
Objectives: To describe the intake of the fat-soluble nutrients retinol, beta-carotene, vitamin E and vitamin D and their food sources among 27 redefined centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Between 1995 and 2000, 36 034 subjects (age range: 35-74 years) completed a single standardized 24-h dietary recall u
Målet med detta arbete är att undersöka på vilken typ av föremål som de första runorna ristades, i vilken arkeologisk kontext som de har hittats, var runinskriptionen suttit på föremålen. Jag hade också som målsättning att ta reda på vilka tolkningar som gjorts till dessa och vilka behov som kan ha legat bakom skapandet och användandet av runorna, varför det skedde just vid den tidpunkten och v
Ett språk är i ständig förändring, nya verb och uttryck myntas hela tiden. Ett språk lånar även ord från andra språk, anledningarna kan vara olika. I denna uppsats undersöks fyra engelska ord (appeal, competitor, design, target) som numera även finns i italienarnas vokabulär. Frågan är: hur används dessa ord i italienskan? Undersökningen har gjorts via ett italienskt corpus och det framgår att desLanguage never stops changing, new verbs and words are established all the time. A language sometimes borrows words from other languages, the reasons for why can differ. This essay investigates four English words (appeal, competitor, design, target) that nowadays can be found in Italian. The question is: how are these words used in Italian? The words have been searched for in an Italian corpus and
Nitro blue tetrazolium (NBT) staining in normal rat retina was previously found to be affected by inhibition of free radical-related enzyme systems, indicating that NBT might be useful as a marker of free radicals. The aim of the present study was to investigate NBT staining in rat retina in vitamin E deficiency and after blue light exposure, and also to measure hydrogen peroxide (H2O2) production
PURPOSE: Helicobacter pylori is a human gastroduodenal pathogen associated with type-B gastritis and gastric cancer. Low gastric tissue antioxidant levels are believed to increase the risk of developing gastric cancer. We investigated whether dietary antioxidant levels protect against infection and type-B gastritis in H. pylori-infected guinea pigs. METHODS: Dunkin-Hartley guinea pigs infected for
A search for neutral heavy resonances is performed in the WW→ e decay channel using pp collision data corresponding to an integrated luminosity of 36.1fb-1, collected at a centre-of-mass energy of 13TeV by the ATLAS detector at the Large Hadron Collider. No evidence of such heavy resonances is found. In the search for production via the quark–antiquark annihilation or gluon–gluon fusion process, u
So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate ha
This study aimed to assess the impact of the current economic crisis on mortality trends in Spain and its effect on social inequalities in mortality in Andalusia. We used data from vital statistics and the Population Register for 1999 to 2011, as provided by the Spanish Institute of Statistics, to estimate general and sex- and age-specific mortality rates. The Longitudinal Database of the Andalusi
The mechanisms driving the development of immunoglobulin E (IgE) antibody repertoires are a matter of debate. Alternatives to the classical view on antibody development, involving somatic mutation and antigen-driven selection of high-affinity variants in germinal centers, have been proposed. Methods: We have re-analyzed the pattern of mutations in previously isolated and characterized human clonal
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