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Sublingual Immunotherapy (SLIT) is a potential efficacious and safe treatment option for patients with respiratory, IgE-mediated allergic diseases. A combined tolerability, dose finding study with a sublingual liquid birch pollen preparation (SB) was conducted.
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This report summaries the work undertaken to date, and provides a platform on which further site selection, training and fieldwork may be undertaken. The outline quantity of sitework is stated, based on a build up of likely time input required. The availability and applicability of the two main datasets, STATS19 and On The Spot (OTS) data, is summarised. Currently, STATS19 has yielded 11 potential
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A CMOS compatible direct write laser lithography technique has been developed for cantilever fabrication on pre-fabricated standard CMOS. We have developed cantilever based sensors for mass measurements in vacuum and air. The cantilever is actuated into lateral vibration by electrostatic excitation and the resonant frequency is detected by capacitive readout. The device is integrated on standard C
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Early erythroblasts from patients with refractory anemia (RA) and RA with ringed sideroblasts (RARS) show constitutive mitochondrial release of cytochrome c. Moreover, mature erythroblasts in RARS, but not in RA, display aberrant accumulation of mitochondrial ferritin (MtF). We analyzed cytochrome c release, MtF expression, and gene expression during erythrold differentiation in bone marrow cells
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A recently suggested geometrical embedding of Bethe-type lattices (branched polymers) in the hyperbolic plane [R. Mosseri and J. F. Sadoc, J. Phys. Lett. 43, L249 (1982); J. A. de Miranda-Neto and F. Moraes, J. Phys. I. France 2, 1657 (1992)] is shown to be only a special case of a whole continuum of possible realizations that preserve some of the symmetries of the Bethe lattice. The properties of
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The antigens of the Cromer blood group system reside on decay accelerating factor (DAF), a protein belonging to the regulators of complement activation family. The blood group system consists of eight high-incidence antigens and three low-incidence antigens. The molecular basis for the antigens is known and, with the exception of IFC, each antigen is the product of a single nucleotide polymorphism
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Positron emission tomography (PET) imaging studies have shown that peak-dose dyskinesia is associated to abnormally high levels of synaptic dopamine (DA) in the caudate-putamen of dyskinetic l-DOPA-treated patients. High striatal extracellular DA levels have also been found in dyskinetic 6-OHDA-lesioned rats as compared to non-dyskinetic ones, suggesting that extracellular DA levels may play a key
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In acute inflammation, infiltrating polymorphonuclear leukocytes (also known as PMNs) release preformed granule proteins having multitudinous effects on the surrounding environment. Here we present what we believe to be a novel role for PMN-derived proteins in bacterial phagocytosis by both human and murine macrophages. Exposure of macrophages to PMN secretion markedly enhanced phagocytosis of IgG
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Heat transfer from a slot air jet impinging on a cylinder shaped food product placed on a solid surface in a semi-confined area as investigated using computational fluid dynamics (CFD). Simulations of a cylinder in cross flow with the k-epsilon, k-omega and SST models in CFX 5.5 were compared with measurements in the literature. The SST model predicts the heat transfer better than the other models
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OBJECTIVE: to correlate the echostructural characteristics of carotid plaques with neurological symptoms and cerebral infarcts. MATERIALS: one hundred and five plaques were studied in 74 patients by colour-flow duplex ultrasound: 39 were symptomatic and 37 were associated with brain infarction on CT scanning. METHODS: the images were digitalised for computer-assisted image standardisation and divi
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Temporal lobe epilepsy (TLE) is frequently accompanied by memory impairments and, although their bases are unknown, most research has focused on the hippocampus. The present study investigated the importance of another medial temporal lobe structure, the perirhinal cortex (Prh), in changes in memory in TLE using kindling as a model. Rats were kindled twice daily with anterior Prh stimulation until
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After its inauguration in 2000, the Oresund bridge has allowed major mobility and flow of manpower, goods, and services between Sweden and Denmark. Was this the vision that Danes and Swedes have imagined over the past century and a half, when thinking of a bridge over the Sound? And, if so, why did it take more than one hundred years in order to start the construction of the øresundsförbindelsen?
