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We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing ele

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We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated thro

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We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple n

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Luuns Grundutbil dni ngsnämnden Närvarande ledamöter Ovriga närvarande David AIm Cornelia Andersson Kristina Cekanovic Sara Håkansson Svante Norrhem Carl Runfors Ann-Kristin Wallengren Manuela Rossing Lena Christensen Lisa Hetherington Fanni Faegersten Katarina Wingkvist PROTOKOLL Datum: 2020-01-30 Sammanträdestid: kl. 09.00- 12.00 Plats: LUXB227 universitetslektor studentrepresentant studentrepre

https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/protokoll/GUBN/Protokoll_GUN_2020.pdf - 2026-08-17

Arbets- och miljömedicin

Arbets- och miljömedicin | Lund Ar be ts - oc h m ilj öm ed ic in S yd Rapport nr 18/2017 Åtgärdsnivåer mot belastningsskada Inger Arvidsson Ergonom, Dr Med Vet Camilla Dahlqvist Biomedicinsk analytiker, doktorand Henrik Enquist Civilingenjör, Tekn Dr Catarina Nordander Överläkare, docent Arbets- och miljömedicin Syd 2017-11-13 1 http://www5.lu.se/upload/GrafiskProfil/Logotyper/Lunds_universitet_C

https://www.vetenskaphalsa.se/wp-content/uploads/2023/10/Atgardsnivaer-mot-belastningsskada.pdf - 2026-08-18

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Purpose: Radiotherapy of moving tumours is a great challenge in cancer treatment. The moving target will lead to “dose-smearing” of the planned dose distribution and a need for larger margins. To reduce the dose to the surrounding healthy tissue, while still ensuring full coverage of the target, other methods for motion compensation is needed. Inversely optimised arc radiotherapy, where the treatm

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En stödjande miljö är centralt för att kunna upprätthålla ett självständigt liv och effektivt aktivitetsutförande, särskilt med ökande ålder. För personer med funktionella begränsningar, som konsekvenserna av en ryggmärgsskada, är balansen mellan personens funktionella kapacitet och miljöns krav av yttersta vikt för att kunna leva ett så välfungerande liv som möjligt. Livslängden efter en ryggmärg

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Lipids are organic molecules vital for living organisms. They are part of cell membranes and provide an important energy reserve once they are digested by our body. They are most commonly known as fats and oils. Some important so-called polar lipids are amphiphilic molecules, which means they have a head group that is water ‘loving’ (hydrophilic) and a hydrocarbon tail is water ‘hating’ (hydrophobNonlamellar lipid liquid crystalline phases have many potential applications, such as for drug delivery, protein encapsulation or crystallization. Lipid liquid crystalline sponge phase (L3) has so far not been very much considered in these applications, in spite of apparent advantages in terms of its flexibility and capacity of forming large aqueous pores able to encapsulate large bioactive molecu

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The present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and GregorThe present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and Gregor

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Vad består materia av? Det är en fundamental fråga som mänskligheten försökt besvara i tusentals år. Vårt svar på den frågan har utvecklats enormt de senaste 200 åren. Atomer, från grekiskans ord för odelbar, bygger upp materian vi ser omkring oss. Det antogs längeatt atomer verkligen var odelbara, men strax innan sekelskiftet år 1900, kom experimentellt bevis från J. J. Thomson, som påvisade attThe papers in this thesis all concern the treatment of colors in perturbative QCD, both in the context of hard scattering cross sections and for parton showers. The complexity of the color structure of QCD increases quickly with the number of external partons. One way of tackling this issue is by using an orthogonal, group theory based, type of bases, called multiplet bases. This is the topic of p

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Popular Abstract in Swedish Many of the energy needs in today’s modern society are fulfilled by sources based on fossil fuels, including non-domestic oil and coal. It is well known that the increase in CO2 emission is the result of human activities, mostly fossil fuel consumption. The use of such fuels is unsustainable and has led to the phenomena such as climate change, political instability in sThe gasification of biomass is a promising route to increase the share of renewable sources in the energy mix. Besides having an overall higher thermal efficiency than combustion, it also offers the possibility of producing gaseous and liquid biofuels that can be used in the transport sector. The use of biomass gasification for energy purposes can help lower the net emissions of greenhouse gases,

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In the age of miniaturization where the physical systems approach the nanoscale limit andwhere more complex materials are created there is necessity for understanding in terms ofquantum mechanics. The understanding then opens and gives possibilities for manipulationand engineering of such systems and thus practical applications.Quantum mechanics states that the electron cannot be characterized as In this thesis we focus on improvements of the description of the electron-electron correlation effects in nonequilibrium nanosystems. We mainly focus on developments of two nonequilibrium methods, namely the formalism of Nonequilibrium Green’s Function and Time Dependent Density Functional Theory and we explore the possibility to improve existing approximations in these theories. A smaller part o

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Internet Metaphors and Norms. To what extent is digital “openness” also creating a modern “Panopticon”? I.e. to what extent is the conceptual imaginary of relevance for the legitimacy of modern data practices in terms of privacy? This paper argues that conceptual battles around what the Internet is and the digital development means are significant battles. The metaphorical descriptions of the inte

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The discovery, at the beginning of the 20th century, that elements can transform into other elements, due to the spontaneous decay of an instable to a stable atomic nuclei, gave rise to a powerful source for age information in many fields of earth science. For impact structures, it is crucial to establish well-defined and precise ages in order to understand how impact events affect the Earth’s geoThe discovery, at the beginning of the 20th century, that elements can transform into other elements, due to the spontaneous decay of an instable to a stable atomic nuclei, gave rise to a powerful source for age information in many fields of earth science. For impact structures, it is crucial to establish well-defined and precise ages in order to understand how impact events affect the Earth’s geo

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The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.

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Background:With a rapidly ageing population, the number of wrist fractures will rise dramatically in the super-elderly (>80 years) group. In previous published studies regarding mortality after wrist fractures elderly are often defined using a rather wide age-span, the threshold has been set to somewhere between 50-70 years. However, elderly defined as a group this way is probably too imprecise. D

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Popular Abstract in Swedish Förmågan hos levande vävnader att läka skador är en basal faktor för överlevnad och utgör grundförutsättningen för all kirurgisk verksamhet. Det finns lokala skillnader beträffande celltyper och tidsförlopp, men mycket talar för att sårläkningsprocessen är principiellt likartad i alla vävnader. Sårläkning indelas i olika faser, varav den första utgöres av en inflammatorWound healing is a multistep process with an initial inflammatory response, followed by synthesis of extracellular matrix components and finalized by a repair phase. One main goal was to determine the impact and adhesive mechanisms of neutrophil recruitment in anastomotic healing in the colon. Passive immunization against CD18 abolished anastomotic accumulation of neutrophils, whereas no effect on