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Production of building materials is connected to a great deal of environmental degradation, and demand for materials is expected to increase. Currently, the construction industry is responsible for 23 % of the global GHG emissions, 40 % of the raw materials consumed globally, and 32 % of the waste generated in Europe. With urbanization and an increasing population, more buildings are needed in the
Instruktion Variabellista för EpiHealth Enkät, version 1.0.1, 2011-12-23 Utformning av dokumentet: Variablerna är uppdelade i tio fikar, en för metadata och de övriga enligt enkätens uppdelning av nio olika underkategorier. I varje filk så är variablerna därefter sorterade i alfabetisk ordning och kommer därmed inte i samma ordning som i enkäten. Variabelnamnen: I enkätens pdf-version står det ett
https://www.epihealth.lu.se/sites/epihealth.lu.se/files/survey_variables_1.0.1_with_statistics.xlsx - 2026-08-22
Currently, a discussion is ongoing among key actors in the Swedish Library System concerning a prospective role for library institutions incorporated within the Swedish system of total defense. This discussion has emerged informed by the lessons learned from the Covid 19 Pandemic, and in light of the Russian invasion of Ukraine 2022, among other notable world events. In this ongoing process and di
Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 3
The report presents the results of a review of the study methods related to vulnerable road user safety that are used today and aims to link accident causation factors to VRU accident risk. The review covered the following categories of study methods: epidemiological studies based on accident and injury data; in-depth accident investigations; naturalistic driving studies; behavioural observations;The report presents the results of a review of the study methods related to vulnerable road user safety that are used today and aims to link accident causation factors to VRU accident risk. The review covered the following categories of study methods: epidemiological studies based on accident and injury data; in-depth accident investigations; naturalistic driving studies; behavioural observations;
Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have implicated microRNAs in the regulation of cancer cell invasion and migration. Here, we show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a central role
Accurate predictions of net ecosystem productivity (NEPc) of forest ecosystems are essential for climate change decisions and requirements in the context of national forest growth and greenhouse gas inventories. However, drivers and underlying mechanisms determining NEPc (e.g., climate and nutrients) are not entirely understood yet, particularly when considering the influence of past periods. Here
The National Institutes of Health hosted a workshop in 2019 to build consensus around the current state of understanding of the pathophysiology of postural orthostatic tachycardia syndrome (POTS) and to identify knowledge gaps that must be addressed to enhance clinical care of POTS patients through research. This second (of two) articles summarizes current knowledge gaps, and outlines the clinical
Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we show that a proportion of human MPM harbor point muta
The Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS) was founded in 2018, with the aim to promote cooperation among vascular professionals within Mediterranean countries. Due to its prominent social and economic impact on national health systems, diabetic peripheral artery was selected as the very first topic to be investigated by the federation. In this second paper, differ
BACKGROUND: Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases.METHODS: Array Comparative Genomic Hybridization (aCGH) was em
SlutsatserTyp 1- och typ 2-diabetes Det finns ett samband mellan att äta medelhavskost och lägre risk att dö i förtid oavsett orsak (måttlig tillförlitlighet). Det finns ett samband mellan att äta en större andel2 fibrer eller baljväxter och lägre risk att dö i förtid oavsett orsak (måttlig tillförlitlighet). Det kan även finnas ett samband mellan att äta en större andel nötter och lägre ris
This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. The focus of the studies was to develop an efficient andconcise strat
Using transition metals in organic synthesis has led to the discovery of new reactions. These novel reactions have enabled different valuable transformations to take place through short synthetic routes and most importantly using a small amount of the metal. This small amount is called a catalytic amount and the metal which is in the form of a complex (with an array of groups of atoms bonded to thNew palladium and nickel complexes based on unsymmetric PCN pincer ligands have been synthesized and fully characterized using different techniques. The substituents on the nitrogen side arm of the ligand have great influence on the cyclometallation and the reactivity of the new complexes particularly in case of nickel. The less sterically hindered PCNMe ligand enabled formation of the trivalent n
At the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion bAt the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion b
The invention of computers revolutionized the way of doing science and in particular the field of mathematics. Computers were faster than any human mind in doing calculations and they did not make mistakes opening a wide range of possibilities that earlier where in practice uncomputable. Scientists observe the behavior of nature and find mathematical equations that model the different phenomena. IThe efficient simulation of thermal interaction between fluids and structures is crucial in the design of many industrial products, e.g. turbine blades or rocket nozzles. The main goal of this work is to present a high order time adaptive multirate parallel partitioned coupled method for the efficient numerical solution of two parabolic problems with strong jumps in the material coefficients that
Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and in
Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and temporal profile. Owing to the inherent fluctuations in free-electron lasers, this
The current paper describes the deictic system of Kamaiurá, a language of the Tupí-Guaraní family. The Kamaiurá system of deictic demonstratives and adverbials has a high degree of complexity, including at least 17 different forms, of which several have different functions. The system codes four levels of Participant deixis, with proximal, medial, distal and far distal deixis. Forms can also code The current paper describes the deictic system of Kamaiurá, a language of the Tupí-Guaraní family. The Kamaiurá system of deictic demonstratives and adverbials has a high degree of complexity, including at least 17 different forms, of which several have different functions. The system codes four levels of Participant deixis, with proximal, medial, distal and far distal deixis. Forms can also code
