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Three founder mutations in BRCA1 and BRCA2 contribute to the risk of hereditary breast and ovarian cancer in Ashkenazi Jews (AJ). They are observed at increased frequency in the AJ compared to other BRCA mutations in Caucasian non-Jews (CNJ). Several authors have proposed that elevated allele frequencies in the surrounding genomic regions reflect adaptive or balancing selection. Such proposals pre
The thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary watThe thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary wat
Projektet HITS/Transparens utforskar hur frivillig användning av informations- och kommunikationsteknologi av privata aktörer kan förbättra informationstransparens i transport av farligt gods. Detta tillvägagångssätt skiljer sig från en lång rad projekt som sedan 80-talet haft ett centralt myndighetsperspektiv på informationshantering kring farligt gods. I linje med tidigare resultat inom forsknin
In order to achieve significant improvements in road safety at the national level, there is a need for a systematic approach to road safety management with clear responsibilities and accountability. In this paper – after a review of the literature on guidelines, recommendations and research findings – twelve essential elements of such a systematic approach is pointed out, and corresponding relevanIn order to achieve significant improvements in road safety at the national level, there is a need for a systematic approach to road safety management with clear responsibilities and accountability. In this paper – after a review of the literature on guidelines, recommendations and research findings – twelve essential elements of such a systematic approach are pointed out, and corresponding releva
This study presents the first results from an ongoing initiative to develop a multi-millennial Baltic tree- ring width (TRW) chronology consisting of 12 floating records from subfossil Scots pines (Pinus sylvestris L.) extracted from three Lithuanian peat-mining areas. The floating series have been complemented with absolutely dated TRW chronologies which were obtained from living trees growing inThis study presents the first results from an ongoing initiative to develop a multi-millennial Baltic tree-ring width (TRW) chronology consisting of 12 floating records from subfossil Scots pines (Pinus sylvestris L.) extracted from three Lithuanian peat-mining areas. The floating series have been complemented with absolutely dated TRW chronologies which were obtained from living trees growing in
Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sampl
The ratio of the electric and magnetic form factors of the proton G(Ep)/G(Mp), which is an image of its charge and magnetization distributions, was measured at the Thomas Jefferson National Accelerator Facility (JLab) using the recoil polarization technique. The ratio of the form factors is directly proportional to the ratio of the transverse to longitudinal components of the polarization of the r
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk fact
Popular Abstract in English This thesis concerns experiments of heat transfer in a rectangular channel with ribs and an obstacle. Liquid crystal thermography (LCT) is used to record the temperature fields in the experiments. LCT is based on measurement of the color response of a heated surface. When illuminated with a white light, the liquid crystals react to temperature changes by changing color,This thesis presents experimental investigations of local heat transfer in a rectangular channel (aspect ratio AR = 4) with continuous transverse ribs as well as an obstacle. Liquid crystal thermography (LCT) is employed to obtain the temperature fields in the heat transfer experiments. The liquid crystal applied here has a red start at 35°C and a bandwidth of 1°C. The work consists of (1) periodi
Popular Abstract in Swedish Det första målet med detta arbete är att beskriva och diskutera järnålderssamhällets utveckling i Skåne. Det andra målet är att diskutera förhållandet mellan Skåne och angränsande områden. Järnålderssamhället var hierarkiskt uppbyggt och styrdes av olika typer av ledare, vanligen hövdingar eller kungar. Olika sociala grupper verkade i samhället för att bibehålla och utThe first purpose of this dissertation is to describe and discuss the development of the Iron Age society in Scania. The second purpose is to discuss the relations between Scania and the neighbouring areas. The Iron Age society was hierarchical and ruled by different types of leaders, usually cheiftains or kings. To maintain and develop the social system different social groups acted in society.
Popular Abstract in Swedish Ämnet för avhandlingen är verbets morfologiska och stilistiska variation i den grekiska versromanen Erotokritos, ett av de främsta exemplen på den kretensiska renässansdiktningen. Undersökningen utgår från de i dikten förekommande verbformernas morfologiska variation, både vad avser stammar, ändelser och augment. Undersökningen koncentreras på de imperfektiva verbformerThe aim of the present study is to examine the polytypia (morphological variation) and semantic differentiations of the verb in Vitsentzos Kornaros' Erotokritos, to understand how these shape poetic style. We examine the stems and the endings in the imperfective active forms. Moreover, we investigate the augmented forms because at an early stage we found that Kornaros employs a degree of poetic li
Digitaliseringen har inte bara revolutionerat vår vardag och hur vi kommunicerar utan även skapat en ny arena för brottslighet. Bland de mest bekymmersamma brotten som har ökat i takt med den digitala utvecklingen är sexuella övergrepp mot barn. I syfte bekämpa och förebygga dessa brott presenterade EU-kommissionen 2022 ett förslag till en förordning som ålägger leverantörer av interpersonella komDigitalization has not only revolutionized our daily lives and how we communicate but has also created a new arena for criminal activity. Among the most concerning crimes that have increased with the rise of digital development is child sexual abuse. In order to combat and prevent these crimes, the European Commission presented a proposal for a regulation in 2022 that obliges providers of interper
Amphibians are globally among the most endangered taxonomic groups of vertebrates. This is partly due to the chytrid fungus Batrachochytrium dendrobatidis (Bd), which causes the disease chytridiomycosis, that have led to eradication of more than 90 species of amphibians worldwide. The spadefoot toad (Pelobates fuscus) is one of the Swedish red listed species (VU) that are at risk of being affecte
Detta examensarbete ämnar att undersöka om och hur man skulle bygga en modell för att kunna beräkna utsläppen av växthusgaser vid förändringar av transmissionskapacitet. Arbetet avhandlar hur det nuvarande elsystemet är uppbyggt och påverkan på utsläppen av växthusgaser ifrån ökad produktion av förnyelsebar elproduktion och ökad transmission av elektricitet. Utifrån att studera vind- och lastdataIn the light of the importance of climate change and the emissions that have induced it, the ability to calculate the effect on emissions by changing transmission capacity is vital. A model to perform such indicative calculations is developed in this thesis. After researching how the current electricity system is organised, the effects on GHG emissions that are expected from increased renewable el
Syftet med detta arbete var att undersöka olika parametrars betydelse för instabilitetsfenomen i ett underspänt balksystem av limträ. Arbetet syftade även till att undersöka den komplexitet av modellering som krävs för att nå tillräcklig noggrannhet med avseende på instabilitet. Komplexitet i modellering avsåg i detta arbete typ av beräkningsmodell avseende geometrisk representation (1D, 2D, 3D) o
Antal fordon i trafiken börjar bli allt fler och fler. Detta leder till att vägar behöver underhållas emellanåt. För att åtgärda vägarna så krävs det vägarbetare på plats, 90% av dessa vägarbetare känner oro dagligen på sitt jobb. Anledningen till deras oro är att många trafikanter inte tar någon hänsyn till vägarbetare, de kör aggressivt, hänsynslöst och över hastighetsgränsen. Under åren 2003-20
Denna masteruppsats undersöker den snabbt växande europeiska marknaden för laddning av elbilar, med fokus på integrationen av batterienergilagringssystem vid laddningsstationer, särskilt för snabbladdning med likström. Genom intervjuer med branschintressenter och experter, samt en omfattande litteraturgenomgång, identifierar studien en eskalerande efterfrågan på batterisystemlösningar. Denna efter
Parents' experiences of child protection investigations - a meeting with society's safety net. The aim of this study was to explore how parents experience child protection investigation processes and further to examine what those investigations are perceived to do and consist of. The study was conducted through a social constructionist approach through which parental experience is seen
