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Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transition from a local to a systemic GAS infection is paralleled by pathogen-driven alterations in IgG homeostasis. Using animal models and a combination of sensitiv
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un
Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the association between the methylation profile of the PPARGC1A gene promoter gene in leukocytes with insulin secretion/sensitivity indexes in normoglycemic women. A standard oral glucose tolerance test (OGTT) and an abbreviated
Introduction: Surface Guided Radiation Therapy (SGRT) is being increasingly implemented into clinical practiceacross a number of techniques and irradiation-sites. This technology, which is provided by different vendors, canbe used with most simulation- and delivery-systems. However, limited guidelines and the complexity of clinicalsettings have led to diverse patterns of operation. With the aim to
The medial temporal lobe (MTL) is connected to the rest of the brain through two main networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the crucial role of the MTL and networks in the physiopathology of Alzheimer's disease (AD), the present study aimed at (1) investigating whether MTL atrophy propagates specifically within the AT and PM networks, and (2) evaluating
The retrotransposon LINE-1 (L1) is central to the recent evolutionary history of the human genome and continues to drive genetic diversity and germline pathogenesis. However, the spatiotemporal extent and biological significance of somatic L1 activity are poorly defined and are virtually unexplored in other primates. From a single L1 lineage active at the divergence of apes and Old World monkeys,
LINE-1 (L1) retrotransposons are a noted source of genetic diversity and disease in mammals. To expand its genomic footprint, L1 must mobilize in cells that will contribute their genetic material to subsequent generations. Heritable L1 insertions may therefore arise in germ cells and in pluripotent embryonic cells, prior to germline specification, yet the frequency and predominant developmental ti
Despite improvements, lung transplantation remains hampered by both a scarcity of donor organs and by mortality following primary graft dysfunction (PGD). Since acute respiratory distress syndrome (ARDS) limits donor lungs utilization, we investigated cytokine adsorption as a means of treating ARDS donor lungs. We induced mild to moderate ARDS using lipopolysaccharide in 16 donor pigs. Lungs were
Vascular dysfunction and organ failure are two distinct, albeit highly interconnected, clinical outcomes linked to morbidity and mortality in human sepsis. The mechanisms driving vascular and parenchymal damage are dynamic and display significant molecular cross talk between organs and tissues. Therefore, assessing their individual contribution to disease progression is technically challenging. He
STUDY QUESTION: Does previous bariatric surgery (BS) in women affect cumulative live birth rate in IVF?SUMMARY ANSWER: Women having had BS seem to have the same cumulative live birth rate as non-operated women of the same BMI at IVF treatment.WHAT IS KNOWN ALREADY: Because of the perinatal risks of obesity to mother and infant as well as impaired outcomes of IVF, obese women are advised to reduce
BACKGROUND: As the global population ages, the demand for palliative care is expected to increase. However, studies show that older patients often receive inadequate palliative care, partly due to healthcare professionals lacking sufficient training and tools to identify and address palliative care needs effectively. This study aims to explore healthcare professionals' experiences regarding facili
With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was an
1 HT2020 – VT2021 Kursanalys MSFM01 Medicinsk strålningsfysik - grundkurs MSFM01: Joniserande strålning: produktion, växelverkan, detektion Produktion Martin Bech Undervisningsform och examination Delkursen är en del av ett block som behandlar joniserande strålnings grunder, bestående av strålningsproduktion, växelverkan och detektorer. Delkursen innehåller c:a 24 föreläsningstimmar (atomär fysik,
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https://www.student.lth.se/stoed-och-service/it-tjaenster-och-support/aktuellt/ - 2026-08-17
Litteraturlista FPPA22 - VT23 Sida 1 av 2 Filosofiska institutionen LITTERATURLISTA VT2023 FPPA22, Praktisk filosofi: Praktisk filosofi, politik och ekonomi – fortsättningskurs, 30 hp Fastställd av Filosofiska institutionens studierektor 2022-11-30 Delkurs 1 – Fördjupad moralfilosofi Hare, Richard: Moral Thinking. Oxford: Clarendon Press, 1981. Svenska utgåvan Moraliskt tänkande, Thales, 1994. Fis
https://www.fil.lu.se/media/utbildning/dokument/kurser/FPPA22/20231/Litteraturlista_FPPA22_VT2023.pdf - 2026-08-16
Litteraturlista FPPA23 - VT26 Sida 1 av 2 Filosofiska institutionen LITTERATURLISTA VT2026 FPPA23, Praktisk filosofi: Praktisk filosofi, politik och ekonomi – fortsättningskurs, 30 hp Fastställd av Filosofiska institutionens studierektor 2025-10-30 Delkurs 1 – Fördjupad moralfilosofi Ross, D: The Right and the Good. Eds (Phillip Stratton-Lake) Oxford: Clarendon Press. 1930/2002. Fisher, Andrew: Me
https://www.fil.lu.se/media/utbildning/dokument/kurser/FPPA23/20261/Litteraturlista_FPPA23_VT2026.pdf - 2026-08-16
LUNDS TEKNISKA HÖGSKOLA TENTAMENSSKRIVNING MATEMATIK FMAA50 – Analys 2 2024-08-19 kl. 14.00–19.00 Hjälpmedel: formelblad Lösningarna ska vara försedda med ordentliga motiveringar och svaren ska förenklas max- imalt. 1. Beräkna a) ∫ 5 0 x √ x dx, (0.2) b) ∫ 4 −1 3x− 8 (x+ 2)(x− 5) dx, (0.4) c) ∫ π 0 sinx 1 + cos2 x dx. (0.4) 2. Lös begynnelsevärdesproblemen a) x2y′ + xy = 1, x > 0, y(1) = 1
https://www.maths.lu.se/fileadmin/matematik_lth_hbg/Analys_2/Tentor/Tentamen_Analys_2_240819.pdf - 2026-08-15
