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Preclinical studies support an anticancer effect of statin drugs, yet epidemiologic evidence remains inconsistent regarding their role in breast cancer primary prevention. Here, we report an updated analysis of the association between statin use and breast cancer incidence in the Nurses' Health Study (NHS) cohort. Postmenopausal NHS participants without a cancer history were followed from 2000 unt
Rationale:The innate immune system and in particular the pattern-recognition receptors Toll-like receptors have recently been linked to atherosclerosis. Consequently, inhibition of various signaling molecules downstream of the Toll-like receptors has been tested as a strategy to prevent progression of atherosclerosis. Receptor-interacting protein 2 (Rip2) is a serine/threonine kinase that is invol
The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles
Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as
Microbial hydrogen (H 2) cycling underpins the diversity and functionality of diverse anoxic ecosystems. Among the three evolutionarily distinct hydrogenase superfamilies responsible, [FeFe] hydrogenases were thought to be restricted to bacteria and eukaryotes. Here, we show that anaerobic archaea encode diverse, active, and ancient lineages of [FeFe] hydrogenases through combining analysis of ex
AIMS: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (
AIMS/HYPOTHESIS: The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the progression from stages 1 or 2 to stage 3 type 1 diabetes.METHODS: Using high-resolution DQA1 and DQB1 genotypes from 1216 participants in the Diabetes Prevention Trial-Type 1 and the Diabetes Prevention Trial, we applied hierarchically orga
AIMS/HYPOTHESIS: The aim of this work was to explore associations between type 1 diabetes progression from stages 1 or 2 to stage 3 and interacting ligand-receptor complexes of HLA class I (HLA-I) and KIR gene products.METHODS: Applying next-generation sequencing technology to genotype HLA-I genes (HLA-A, -B, -C) and KIR genes (KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS3
Pediatric randomized controlled trials (RCTs) inform decisions concerning the choice of interventions in children and adolescents. To enable the implementation of effective interventions, RCT reports need to provide adequate details on the elements, infrastructure, and delivery of these interventions. Using the 12-item Template for the Intervention Description and Replication (TIDieR) framework, a
Background Limited data exist on long-term survival of patients requiring admission to intensive care units (ICUs). The aim of this study was to investigate long-term survival of ICU patients in Iceland and assess changes over a 15-year period. Methods Data were collected on age, gender, admission cause, length of stay, comorbidities, mechanical ventilation and survival of patients 18 years and ol
BACKGROUND: Childhood cancer survivors (CCS) are reported to have decreased bone mineral density (BMD).PURPOSE: Is premature ovarian insufficiency (POI) an important risk factor for low BMD in CCS at long term follow-up?PATIENTS AND METHODS: Altogether 167 female CCS, median age 34 (19-57) years, treated for childhood cancer under age 18 years between 1964 and 2008, with a follow-up time of 25 (12
Nobelpristagare nätverkar bredare LU tar hem mest EU-medel Interna bråk kan främja forskning Vem var du? LUNDS UNIVERSITETS MAGASIN | NR 5 | 2019 SÖKER LIVSHISTORIERNA BAKOM ARKIVERADE KVARLEVOR 2 LUM NR 5 | 2019 Dubbla handskar samt gas- mask, skyddsglasögon, plast- förkläde och gummistövlar krävs när Fredrik Terfelt ska arbeta i labbet. I ett moment hälls 70-procentig salpeter- syra ner i provet
https://www.lu.se/sites/www.lu.se/files/lum_5_2019.pdf - 2026-10-04
LUM Lunds universitets magasin | Nr 1 | 2009 forskning forever Historisk lycka mest olycka Rektor vill göra LU mer synligt 2 LUM nr 1 | 2009 speglingar av akademin LUM nr 1 | 2009 3 Under sin tid som rektor för Lunds universitet traskade Håkan West- ling många gånger med utländska gäster från Domkyrkan och nord- ost, förbi nästan alla universitetets byggnader, upp till Ideon. Redan då föddes idén
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-1-2009.pdf - 2026-10-04
Anvisningar gällande kursplaner på grundnivå och avancerad nivå vid naturvetenskapliga fakulteten Anvisningar gällande kursplaner på grundnivå och avancerad nivå vid naturvetenskapliga fakulteten Beslut i utbildningsnämnden 2022-03-17 Reviderad av utbildningsnämnden 2024-12-05 Ikraftträdandedatum 2024-12-05 Dnr STYR 2024/3063 Innehåll Inledning .....................................................
BACKGROUND: Experimental animal studies suggest a novel role for the folate receptor 1 in β-cell differentiation in the pancreas, with potential implications for glycemic control. We tested the hypothesis of a protective association between prenatal folic acid use and neonatal diabetes or hyperglycemia and type 1 diabetes in an observational cohort study using data from the national population hea
Popular Abstract in Swedish Graviditetsdiabetes (GDM) definieras som förhöjt blodglukos (blodsocker) som uppstår eller upptäcks under graviditet och som oftast försvinner efter förlossningen. Orsaken anses vara en otillräcklig förmåga att öka insulinproduktionen i takt med det ökade behov som normalt uppträder under en graviditet till följd av hormonella förändringar. Livsstilsfaktorer såsom stillGestational diabetes mellitus (GDM) is associated with a risk of adverse pregnancy outcome and is a predictor of subsequent diabetes. The aims of this work were to describe a reliable routine to diagnose abnormal glucose tolerance during pregnancy, to investigate women’s opinions of the specialist care provided, to determine the prevalence of diabetes one year after giving birth, and to elucidate
LUNDS UNIVERSITETS MAGASIN | NR 1 | 2025 1968–2025 2 LUM NR 1 | 2025 Sektionen Kommunikation organiseras om: I samband med omstöpningen läggs LUM ner efter beslut från universitetsledningen. Enligt kommunikationsdirektör Johanna Sandahl, som har tagit fram förslaget till ny organisation, krävs omprioriteringar för att kunna tillmötesgå ledningens och verksam hetens förväntningar på kommunikations
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2025-02/LUM%201%202025_0.pdf - 2026-10-04
NYBLIVNA PSYKOLOGERS SKATTNINGAR OCH UPPLEVELSER: DE TRE FÖRSTA ÅREN EFTER EXAMEN UMEÅ Ingrid Schéle och Jaco Pienaar, Institutionen för psykologi, Umeå universitet Camila Frelijj González och Robin Hakola, psykologprogramstudenter Kontaktperson Ingrid Schéle, ingrid.schele@umu.se mailto:ingrid.schele@umu.se 2 Abstrakt Långvariga sjukskrivningar på grund av maladaptiva stressreaktioner, är i Sveri
https://www.psy.lu.se/sites/psy.lu.se/files/bil_6-2017_p7_alumnienkat_rapport_lund.pdf - 2026-10-04
Språk- och litteraturcentrum Arabiska LITTERATURLISTA ARAA20, Arabiska: Nybörjarkurskurs (30hp) Arabic: Elementary Course (30 credits) Fastställd av lärarkollegium 5 den 10 december 2012 Reviderad av Styrelsen för Sektion 5 den 27 november 2025 ----------------------------------------------------------------------------------------------------------------- Kurslitteratur (obligatorisk) Abu-Chacra,
https://www.sol.lu.se/media/utbildning/dokument/kurser/ARAA20/20261/ARAA20_Litteraturlista_VT26.pdf - 2026-09-14
