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Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is <0.2% of that in beta cells. The GLP-1-induced suppression of glucagon secretion is PKA dependent, is glucose indep
OBJECTIVE: To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men. METHODS: The European Male Ageing Study (EMAS), a multicenter population-based study of men aged 40-79 years, was used to investigate this hypothesis. A questionnaire asked about the presence and duration of musculoskeletal pain, allowing subjects t
BRCA1 and BRCA2 screening in women at high-risk of breast cancer results in the identification of both unambiguously defined deleterious mutations and sequence variants of unknown clinical significance (VUS). We examined a population-based sample of young women with contralateral breast cancer (CBC, n=705) or unilateral breast cancer (UBC, n=1398). We identified 470 unique sequence variants, of wh
COVID-19 is a major public health threat associated with increased disease burden, mortality, and economic loss to countries and communities. Safe and efficacious COVID-19 vaccines are key in halting and reversing the pandemic. Low confidence in vaccines has been one of the factors leading to hesitancy. We aimed to assess the COVID-19 vaccine confidence (safety and effectiveness), associated facto
PURPOSE: To determine whether β-microseminoprotein or any of the kallikrein forms in blood-free, total or intact PSA or total hK2-predict metastasis in patients with evidence of detectable levels of PSA in blood after radical prostatectomy.METHOD: We determined marker concentrations in blood from 173 men treated with radical prostatectomy and evidence of detectable levels of PSA in the blood (PSA
Since its heyday in the 1960 and 70s, the sociology of literature has been declared dead and gone, yet research related to the field also seems to be reemerging in the first decades of the 21st century. Research relating to the field is scattered across other disciplines, such as literary studies, media studies and cultural studies; indeed, sociology of literature is “everywhere and nowhere”, as J
The use of vaccines is one of the key tools in reversing the COVID-19 pandemic; however, various reports reported the low uptake of the vaccines. This study explored the barriers to the COVID-19 vaccine uptake among community members in Tanzania. A qualitative explorative study was conducted in December 2021 and April 2022 in eight regions of Tanzania. Focus group discussions (FGDs) and in-depth i
The elemental composition of the St. Louis aerosol has been investigated at rooftop sites in south and central locations in the city as part of the August, 1973 field season of the Regional Air Pollution Study of the U.S. Environmental Protection Agency. Sampling by 5-stage cascade impactor with backup filter permits analysis by proton-induced x-ray emission (PIXE) of size fractions of aerodynamic
Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in health
RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different
Eutrophication is a serious problem in many parts of the world, and aquaculture production can contribute to the problem as well as be part of its solution. Nutrient polices in developed countries are often command-and-control policies that may have contributed to the slow growth of the sector. We perform a literature review to investigate how current nutrient polices affectEutrophication is a serious problem in many parts of the world, and aquaculture production can contribute to the problem as well as be part of its solution. Nutrient polices in developed countries are often command-and-control policies that may have contributed to the slow growth of the sector. We perform a literature review to investigate how current nutrient polices affect the sector and if econ
In this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and variaIn this paper, we investigate the distributional properties of the estimated tangency portfolio (TP) weights assuming that the asset returns follow a matrix variate closed skew-normal distribution. We establish a stochastic representation of the linear combination of the estimated TP weights that fully characterizes its distribution. Using the stochastic representation we derive the mean and varia
The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchan
High-risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high-risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3-related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically
The critique of the legal form of capitalism by E. B. Pashukanis has risen to prominence once again. However, the negative origin of the concept of the legal form, the critique of formalism and instrumentalism, has received too little attention. This essay substantiates the significance of Pashukanis’s critique, avoiding both overly general and narrow conceptions. Moreover, it proposes that his ne
Svenska, språklig inriktning 1–40 poäng Vårterminen 2024 Litteraturlista för SVEA20, Svenska, språklig inriktning – fortsättningskurs, 30hp Fastställd av sektion 1 vid Språk- och litteraturcentrum den 30 maj 2023. Delkurs 1: Fonetik och fonologi (1,5 hp) Obligatorisk kurslitteratur Delsing, Lars-Olof (1991, rev.1997, 2006, 2017). Fonetikkompendiet. (27 s.) Hämtas ner digitalt enligt lärarens anvis
https://www.sol.lu.se/media/utbildning/dokument/kurser/SVEA20/20241/SVEA20_VT24.pdf - 2026-08-21
Geokronologi och paleomagnetiska studier är de viktigaste verktygen för paleogeografiska rekonstruktioner kring hur kontinenter fårhållit sig relativt till varandra under geologisk tid. Genom att jämföra s.k. polvandringskurvor och tidpunkter för storskaliga magmatiska händelser mellan olika krustala block (kontienter/kratoner) kan vi få en bättre förståelse av hur dessa block förhöll sig relativtRobust geochronology and well-constrained paleopoles are the main tools for paleogeographic reconstructions. Through the completion of so called barcode diagrams (matching of coeval events of mafic magmatism between blocks) and determination of the apparent polar wander paths, these studies provide a better understanding of the position of continents and supercontinents in the past. The robust U–P
Hur destinationer arbetar med utveckling och marknadsföring för att attrahera turister är två välutforskade områden. Att se på destinationers utveckling och marknadsföring ur ett resebolags perspektiv är idag outforskat. Eftersom det är resebolagen som tillhandahåller resor till turisten anser vi att detta perspektiv är av största intresse att behandla. Vad krävs då för att en destination ska vara
