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PURPOSE: The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs). PATIENTS AND METHODS: Samples from 48 MPNSTs and 10 neurofibromas were collected from 51 patients with (n = 31) or without (n = 20) neurofibromatosis type 1 (NF1). Genome-wide DNA copy number changes were assessed by chromosomal and ar

A de novo alpha-synuclein A53T (p.Ala53 Th; c.209G > A) mutation has been identified in a Swedish family with autosomal dominant Parkinson's disease (PD). Two affected individuals had early-onset (before 31 and 40 years), severe levodopa-responsive PD with prominent dysphasia, dysarthria, and cognitive decline. Longitudinal clinical follow-up, EEG, SPECT and CSF biomarker examinations suggested an

Preclinical studies support an anticancer effect of statin drugs, yet epidemiologic evidence remains inconsistent regarding their role in breast cancer primary prevention. Here, we report an updated analysis of the association between statin use and breast cancer incidence in the Nurses' Health Study (NHS) cohort. Postmenopausal NHS participants without a cancer history were followed from 2000 unt

Rationale:The innate immune system and in particular the pattern-recognition receptors Toll-like receptors have recently been linked to atherosclerosis. Consequently, inhibition of various signaling molecules downstream of the Toll-like receptors has been tested as a strategy to prevent progression of atherosclerosis. Receptor-interacting protein 2 (Rip2) is a serine/threonine kinase that is invol

Microsoft Word - Kartläggning av föremålets ägare.docx   I                                                                                              En kartläggning av föremålets ägare             Lunds Universitet Institutionen för arkeologi och antikens historia Victor Lundström: 891123-4972 ARKA12:3, VT2013 Handledare: Jan Apel     II   En kartläggning av föremålets ägare A survey of the obj

https://www.ark.lu.se/media/utbildning/dokument/kurser/ARKA12/20131/Victor_Lundstrm.pdf - 2026-07-31

Kopia av kallelse som skickats till antagna studenter sommaren 2020 Välkommen till Historiska institutionen vid Lunds universitet! Du är antagen till en utbildning hos oss. Det finns några saker som är extra viktiga för att du ska ta din plats i anspråk: 1) Webbregistrering Du måste webbregistrera dig i studentportalen innan kursen startar. Om du inte registrerar dig inom angiven tid kan din plats

https://www.historiska.lu.se/fileadmin/user_upload/historiska/hist/Historia/dokument_utb_Hist/Kallelse_-_sommarkursvt20.pdf - 2026-07-31

BACKGROUND AND PURPOSE: Although serine proteases and agonists of protease-activated receptor 2 (PAR2) cause inflammation and pain, the spectrum of proteases that are activated by proinflammatory and algesic stimuli and their contribution to inflammatory pain are uncertain.EXPERIMENTAL APPROACH: Enzymic assays and selective inhibitors were used to characterize protease activity in mice after intra

Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w

BACKGROUND: Methylmercury (MeHg) is present in fish and is a neurotoxicant at sufficiently high levels. One potential mechanism of MeHg toxicity early in life is epigenetic dysregulation that may affect long-term neurodevelopment. Altered DNA methylation of nervous system-related genes has been associated with adult mental health outcomes.OBJECTIVE: To assess associations between prenatal MeHg exp

Denna studie syftar till att synliggöra erfarenheter och berättelser från barn till exilflyktingar från Abya Yala som flydde till Sverige, under 70–80 talet, och lyfter hur trauman, minnen och politiska arv påverkar barnens liv – även i vuxen ålder. Genom en dekolonial logik och metodologi undersöks även hur storytelling, autohistoria, chicanafeministisk epistemologi och investigacion-acción partiThis study aims to make visible the experiences and stories of children of exiled refugees from Abya Yala who fled to Sweden, during the 70s and 80s, highlighting how trauma, memories, and political legacies affect the lives of the children – even in their adulthood. Through a decolonial logic and methodology, it also explores how storytelling, autohistory, chicana feminist epistemology and invest

BACKGROUND: Childhood cancer survivors (CCS) are reported to have decreased bone mineral density (BMD).PURPOSE: Is premature ovarian insufficiency (POI) an important risk factor for low BMD in CCS at long term follow-up?PATIENTS AND METHODS: Altogether 167 female CCS, median age 34 (19-57) years, treated for childhood cancer under age 18 years between 1964 and 2008, with a follow-up time of 25 (12

Praktikplan HT-fakulteterna Kompletterande ansökningsblankett – erbjudande om praktikplats SVED01 och SVED02 I detta dokument visar du att du har fått ett erbjudande om en praktikplats och beskriver i stora drag vilket innehåll din praktik kommer att ha. Dokumentet ska laddas upp på dina sidor senast sista kompletteringsdag (se antagning.se för datum). Om vi godkänner praktikplatsen, och om du upp

https://www.sol.lu.se/media/utbildning/dokument/kurser/SVED01/20232/SVED01_02_Kompletterande_anso_kningsblankett_augusti_2023.pdf - 2026-07-31

OBJECTIVE: To explore associations of HLA class II genes (HLAII) with the progression of islet autoimmunity from asymptomatic to symptomatic type 1 diabetes (T1D).RESEARCH DESIGN AND METHODS: Next-generation targeted sequencing was used to genotype eight HLAII genes (DQA1, DQB1, DRB1, DRB3, DRB4, DRB5, DPA1, DPB1) in 1,216 participants from the Diabetes Prevention Trial-1 and Randomized Diabetes P

Bacterial or viral antigens can contain subdominant protein regions that elicit weak antibody responses upon vaccination or infection although there is accumulating evidence that antibody responses against subdominant regions can enhance the protective immune response. One proposed mechanism for subdominant protein regions is binding of host proteins that prevent antibody production against epitop

Microbial hydrogen (H 2) cycling underpins the diversity and functionality of diverse anoxic ecosystems. Among the three evolutionarily distinct hydrogenase superfamilies responsible, [FeFe] hydrogenases were thought to be restricted to bacteria and eukaryotes. Here, we show that anaerobic archaea encode diverse, active, and ancient lineages of [FeFe] hydrogenases through combining analysis of ex

AIMS: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (

Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly lung and lymph nodes, drastically reduces overall survival. However, mechanistic insight how CCA invades these metastatic sites is still lacking. This is partly because currently available models fail to mimic the complexity

Different tau biomarkers become abnormal at different stages of Alzheimer's disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture the earliest changes of tau accumulation, we implemented an observational study design to examine longitudinal changes in Tau-PET, cortical thickn