Filetype
Background: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential. Objectives: The authors de
Atomic oxygen (O) is vital in plasma-assisted combustion, but its quantitative measurement is challenging and therefore rarely reported. This work performs femtosecond two-photon-absorption laser-induced fluorescence (fs-TALIF) imaging to quantify the dynamics of atomic oxygen production by a single nanosecond (ns) pulsed plasma discharge in an ammonia/air flame for the first time. First of all, t
Objective: To assess comparative effectiveness, safety, and tolerability of off-label rituximab, compared with frequently used therapies approved for multiple sclerosis (MS). Methods: A Swedish cohort study of persons with relapsing–remitting MS, age 18 to 75 years at inclusion and with a first therapy start or a first therapy switch between 2011 and 2018. Low-dose rituximab was compared with MS-a
Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem
BACKGROUND: The COVID-19 pandemic has highlighted the importance of evidence-informed priority setting and situational analysis in pandemic preparedness and response. Health Technology Assessment (HTA) has been identified as an essential tool for evidence-informed decision-making in healthcare. However, the potential role of HTA in pandemic preparedness and response in Africa has yet to be explore
North Sea-Progressive Myoclonus Epilepsy (NS-PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early-onset ataxia, cortical myoclonus and epilepsy. Recently, the spectrum of GOSR2 mutations and associated phenotypic variability has expanded. To improve care and to facilita
Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. Methods: We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10
Background: The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods: This review included studies published in English language from January 1st, 1990, through
Objective: Exercise is a first-line intervention for osteoarthritis (OA). However, exercise adherence remains low, and existing studies exploring factors influencing adherence have yielded inconclusive results based on quantitative data. This study aims to synthesise qualitative studies focused on the perceived facilitators and barriers affecting exercise adherence in individuals with OA. Design:
Irony is a heavily context-dependent pragmatic phenomenon. But what is it about context that facilitates or blocks irony comprehension? Based on the echoic account, we suggest that a context facilitates irony comprehension when it makes manifest a speaker's intentions and attitude, i.e., when a context makes it easy for participants to engage their mindreading abilities. In two pre-registered self
Age-Friendly Cities and Communities (AFCC) is a key global WHO initiative aimed at fostering environments that promote healthy aging for everyone. As AFCC initiatives continue to expand, there is an increasing need to enhance monitoring and evaluation systems to effectively assess their progress and impact. However, significant knowledge gaps persist, particularly in the development of evaluation
Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a conclu
Background: Measuring health-related quality of life (HRQoL) in dialysis patients is essential for clinical assessment and economic evaluation. Despite the emergence and increasing use of updated instruments, evidence comparing their performance in Chinese dialysis patients remains limited. The aim of this study was to compare the measurement properties of the EQ-5D-5L and the SF-6Dv2 instruments
Narratives in Medicine: Human Dimensions in a Tech-DrivenHealthcare and SocietyMats Arvidson, Ph. D., Senior Lecturer and Associate Professor, Lund UniversityThe Transboundary Body: Illness Narrative, Intermediality, and MedicalTechnologyThis paper explores how contemporary treatment technologies reshape the possibilities of illness narrative across lived experience, philosophy, and film. Emerging
IntroductionAlthough transcranial sonography (TCS) assessing hyperechogenic substantia nigra (SN+) as biomarker for Parkinsońs disease (PD) has been introduced elsewhere, the clinical relevance and accuracy in a Swedish population is still unknown.MethodsThis retrospective single-center study included 74 patients with predominantly early-stage parkinsonism at first visit who had been examined by T
Purpose: To assess perceived overall knowledge in geriatric medicine and perceived educational needs in key geriatric topics and skills of health and social care professionals working within the WHO Region Europe. Methods: The sample of this cross-sectional survey was not designed to be nationally representative. We analysed the responses of 5425 professionals who completed a multilingual multinat
In 2022, the Swedish Women's Hockey League (SDHL) became the first women's league in the world to allow body checking. This study examines injury epidemiology in SDHL 2 years after this policy change. Injuries resulting in time loss from training or games were recorded in a digital injury-reporting system. This study utilizes game-related injuries that occurred during the seasons 2022-2023 and 202
The Water-Energy-Food (WEF) nexus provides a critical framework for addressing interdependencies among these resources in the Middle East and North Africa (MENA), where limited water, arid climate, high energy demand, and growing populations pose significant sustainability challenges. Over-exploitation of groundwater in Yemen, energy-dependent desalination in Saudi Arabia, and water stress in Moro
Internal head- and neck lymphedema (I-HNL) is a common side effect after head and neck cancer treatment, but the current assessment and rehabilitation practices remain unclear. The purpose of this study was to explore how Swedish speech and language pathologists (SLPs), physiotherapists (PTs), and lymphedema therapists (LTs) assess and treat I-HNL and how they perceive their competence in doing so
