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There has not been a satisfying numerical validation of the theory of effective waves in random particulate materials. Validation has been challenging because the theoretical methods for effective waves have been limited to random particulate media in infinite slabs or half-spaces, which require a very large number of particles to perform accurate numerical simulations. This paper offers a solutio
Central and Eastern Europe (CEE) needs to become an attentive listener if its countries want to advocate for its interests more effectively. With the war in Ukraine ongoing and the challenge of the country’s reconstruction looming on the horizon, the regional decision-makers have to show more understanding of the challenges faced by their partners in other parts of the continent. They also need to
Social work with homeless/ness in Sweden is usually performed by social services in local municipalities highly dependent on local, non-state actors, especially landlords’ goodwill, to cooperate with social services and support vulnerable peoples’ housing. The social services dependency on such actors is challenging and exploitation by landlords can affect the actual organization of social service
As products and supply chains (SCs) evolve, logisticians must revisit their under-standing of postponement. The postponement boundary problem acknowledges that value- adding operations' timing and location in global SCs are critical decisions, impacted by taxes and government regulations in different jurisdictions. However, when combining hardware and software objects, software's increasing import
Global supply chain management concerns the management of sourcing, manufacturing, and distribution that take place in different countries before a product is sold and delivered to the final buyers. From the view of the focal manufacturing firm, a global supply chain consists of three key parts: the upstream supply network, the manufacturing network of plants belonging to the focal firm, and the d
BACKGROUND: Bacterial infection causes accumulation of neutrophils that release antimicrobial proteins including heparin-binding protein (HBP). In human airways, this neutrophil accumulation can be re-capitulated via intrabronchial exposure to lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) agonist, that also causes a local increase in the neutrophil-mobilizing cytokine IL-26. Although LPS
Efficiently finding covariate model structures that minimize the need for random effects to describe pharmacological data is challenging. The standard approach focuses on identification of relevant covariates, and present methodology lacks tools for automatic identification of covariate model structures. Although neural networks could potentially be used to approximate covariate-parameter relation
Introduction: The directionality of semantic change is problematic in traditional comparative models of language reconstruction. Compared to, e.g., phonological and morphological change, the directions of meaning change over time are potentially endless and difficult to reconstruct. The current paper attempts to reconstruct the mechanisms of lexical meaning change by a quantitative model. We use a
We studied the prevalence and patterns of typical long COVID complaints in ~ 2.3 million individuals aged 18–70 years with and without confirmed COVID-19 in a Nation-wide population-based prospective cohort study in Norway. Our main outcome measures were the period prevalence of single-occurring or different combinations of complaints based on medical records: (1) Pulmonary (dyspnea and/or cough),
The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto
