Expression and Purification of Recombinant Human S100A8 and S100A9 for Characterization of Their Roles as Danger Signals
The direct involvement of S100 calcium-binding proteins A8 (S100A8) and A9 (S100A9) in numerous human diseases have been discovered more than 20 years ago, and they have ever since emerged as a very potent biomarker. Increased levels of S100A8 and S100A9 have been found in inflammation and various cancers. As complexes, they become crucial danger signals and act as endogenous activators of TLR4 (T