A reduced number or dysfunction of inhibitory interneurons is a common contributor to neurodevelopmental disorders. Therefore, cell therapy using interneurons to replace or mitigate the effects of altered neuronal circuits is an attractive therapeutic avenue. To this end, more knowledge is needed about how human stem cell-derived GABAergic interneuron-like cells (hdINs) mature, integrate, and func

Age frequently carries the burden of diseases, many of which in turn are associated with discomfort and various complaints. Chronic pain is such a common complaint and is an important issue in the care of older people, and perhaps the most important problem in their daily lives. It is known to, alone or together with other factors, negatively affect an older person's quality of life. Examples of c

The possible role of somatic copy number variations (CNVs) in Alzheimer’s disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a recent single-cell whole-genome sequencing (scWGS) experiment, studying frontal cortex brain samples, found no such evidence. Here we readdressed this issue using low-coverage scWGS on pyramidal neurons d

Augmented reality (AR) games are a rich environment for researching and testing computational systems that provide subtle user guidance and training. In particular computer systems that aim to augment a user's situation awareness benefit from the range of sensors and computing power available in AR headsets. The main focus of this work-in-progress paper is the introduction of the concept of the in

Background: Sexual harassment (SH) in the workplace is prevalent and associated with poor health. Universities are large workplaces with complex formal and informal power relations, which may influence the prevalence of SH. Although employees and students share the university context, few studies on SH have included both groups. The overall aim of the study was to investigate SH among employees an

OBJECTIVE: to examine the association between different patterns of impaired lung function with the incident risk of dementia and magnetic resonance imaging (MRI)-based brain structural features. METHODS: in UK Biobank, a total of 308,534 dementia-free participants with valid lung function measures (forced expiratory volume in 1 s [FEV1] and forced vital capacity [FVC]) were included. Association

The magnon Hedin's equations are derived via the Schwinger functional derivative technique, and the resulting self-consistent Green's function (GF) method is used to calculate ground state spin patterns and magnetic structure factors for two-dimensional magnetic systems with frustrated spin-12 Heisenberg exchange coupling. Compared with random phase approximation treatments, the inclusion of a sel

Background: HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies of HPV in penile cancer have been performed using paraffin-embedded tissue, argued to be at risk for contaminated HPV analysis. Viral activity of HPV, by the use of HPV mRNA expres

Flip-flop processes due to magnetic dipole-dipole interaction between neighboring ions in crystals doped by rare-earth ions are one of the mechanisms of relaxation between hyperfine levels. Modeling of this mechanism has so far been macroscopic, characterized by an average rate describing the relaxation of all ions. Here, however, we present a microscopic model of flip-flop interactions between in

Neoliberal and conservative actors, financed by the fossil fuel industry, have been identified as crucial parts of a climate change denialist counter movement since at least the 1980s. We claim that this intersection stems from more than just vested interest fuelling advocacy groups. By focusing on the intellectual developments and social networks of core actors in the environmental debate in Swed

Approximately 40% of earth's carbon (C) stored in land vegetation and soil is within the boreal region. This large C pool is subjected to substantial removals and transformations during periodic wildfire. Fire-altered C, commonly known as pyrogenic carbon (PyC), plays a significant role in forest ecosystem functioning and composes a considerable fraction of C transport to limnic and oceanic sedime

In mudflats, interactions and transfers of nutrients and secondary metabolites may drive ecosystems and biodiversity. Foraminifera have complex trophic strategies as they often rely on bacteria and eukaryotes or on potential symbionts for carbon and nitrogen resources. The capacity of these protists to use a wide range of adaptive mechanisms requires clarifying the relationships between them and t

Flame front visualization using methyl photofragmentation laser-induced fluorescence (CH3-PF-LIF) was demonstrated in turbulent premixed methane/air flames. A pump–probe method was used to detect CH3, where CH3 was first photolyzed to CH (X2П) fragments using a pump laser (212.8 nm), and the fragments were subsequently excited to CH in the C2Σ+ state by a probe laser at 314.4 nm. By detecting fluo

Household burning of solid biomass fuels emits pollution particles that are a huge health risk factor, especially in low-income countries (LICs) such as those in Sub-Saharan Africa. In epidemiological studies, indoor exposure is often more challenging to assess than outdoor exposure. Laboratory studies of solid biomass fuels, performed under real-life conditions, are an important path toward impro

This paper contains an introduction, probabilistic formulation, and exemplification (1) of system state and utility actions, (2) system state and utility action value analysis and (3) a threshold formulation for a predicted information and action decision analysis. The approaches build upon structural condition assessment and provide a basis for the condition management by maximising the expected

The levelized cost of energy (LCoE) is an important measure to quantify the macro-economic efficiency of an offshore wind farm and to enable a quantitative comparison with other types of energy production. The costs of the structural integrity management - which is required to ensure an adequate lifetime reliability of the turbine support structures - are part of the operational expenditures of an

The number of people who live in bushfire-prone areas around the world is growing. In Australia, in the states of Victoria and New South Wales, over 1.5 million people live in areas rated as high to extreme bushfire risk in (SGS Economics and Planning 2019). As effects of climate change increase the size and severity of bushfires, and a greater number of people move into these at-risk areas, there

In this paper we address absolute camera pose estimation. An efficient (and standard) way to solve this problem, is to use sparse keypoint correspondences. In many cases point features are not available, or are unstable over time and viewing conditions. We propose a framework based on silhouettes of quadric surfaces, with special emphasis on cylinders. We provide mathematical analysis of the probl

Context. Energy and momentum injected by young, massive stars into the surrounding gas play an important role in regulating further star formation and in determining the galaxy's global properties. Before supernovae begin to explode, stellar feedback consists of two main processes: Radiation pressure and photoionisation. Aims. We study pre-supernova feedback and constrain the leakage of Lyman cont