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OBJECTIVES:To report the initial experience of an international group of investigators in identifying mutations in the BRCA1 breast and ovarian cancer susceptibility gene, to assess the spectrum of such mutations in samples from patients with different family histories of cancer, and to determine the frequency of recurrent mutations.DESIGN:Nine laboratories in North America and the United Kingdom

This paper shows how the Computer Revolution of the 1980s shifted the economic trajectories of U.S. cities. Examining the emergence of new occupational titles in official census classifications, we document a sharp reversal in the skill content of new jobs. While technological change was biased towards routine skills throughout the 1970s, new job titles mainly appeared in occupations and industrie

Industrial renewal in the 21st century: evidence from US cities. Regional Studies. Where and why do new industries emerge? Using revisions of official industrial classifications, this paper documents the appearance of new industries in the US economy between 2000 and 2010 stemming directly from technological advances. Examining differences in new industry creation across cities, this paper shows t

A vast literature documents a positive relationship between patents and companies stock market performance. Nevertheless, evidence on the influence of patents on companies’ debt capacity remains sparse. In this article, we examine the relationship between companies’ patent portfolios and their credit rating, providing relevant, albeit indirect, evidence on patents as a debt funding mechanism. Usin

We study the rise of the so-called “gig economy” through the lens of Uber and its drivers in the United Kingdom. Using administrative data from Uber and a new representative survey of London drivers, we explore their backgrounds, earnings, and subjective well-being. We find that the vast majority of Uber drivers are male immigrants, primarily drawn from the bottom half of the London income distrib

Aim: Vegetation structure is a key determinant of animal diversity and species distributions. The introduction of Light Detection and Ranging (LiDAR) has enabled the collection of massive amounts of point cloud data for quantifying habitat structure at fine resolution. Here, we review the current use of LiDAR‐derived vegetation metrics in diversity and distribution research of birds, a key group f

Biogenic volatile organic compounds (BVOCs) can be released from soils to the atmosphere through microbial decomposition of plant residues or soil organic carbon, root emission, evaporation of litter-stored BVOCs, and other physical processes. Soils can also act as a sink of BVOCs through biotic and abiotic uptake. Currently, the source and sink capabilities of soils have not been explicitly accou

This study focuses on quantitative long-term effects of Supplemental Instruction (SI) in terms of graduation and dropout rates. One of the main aims of SI is to introduce students to effective study strategies and techniques. If SI is introduced at an early stage for new students in higher education, it should therefore be expected that this action will promote timely graduation. This has also beeThis study focuses on quantitative long-term effects of SupplementalInstruction (SI) in terms of graduation and dropout rates. One of the main aimsof SI is to introduce students to effective study strategies and techniques. If SIis introduced at an early stage for new students in higher education, it shouldtherefore be expected that this action will promote timely graduation. This hasalso been ind

A field study on current structure and circulation characteristics in Lake Vendyurskoe, a small, shallow, icecovered lake in Karelia, Russia, is presented. The current velocity magnitudes were generally found to be small. The most pronounced currents had an oscillating character, with velocity amplitudes on the order of millimeters per second. The oscillation period, obtained from spectral density

Using water balance computations, the behavior of different kinds of lakes is discussed. Simple analytical expressions relating water level to hydrological conditions and lake bathymetry are given. The importance of knowing the river basin area when analyzing lake levels is stressed. A conceptual rainfall-runoff model including lake routing is used to simulate runoff and lake levels and to compute

The overall circulation pattern in spring is rather specific as density-induced currents may be of significance. The density-driven circulation perpendicular to the shore can be described as consisting of two circulation cells, with a zone of convergence, referred to as thermal bar, in between. The thermal bar, which coincides with the 4°C isotherm (the temperature of maximum density), inhibits ho

A study on characteristics of currents and mixing in a shallow ice‐covered Russian lake is presented. The current velocity data are separated into four main components, mean velocity, uninodal longitudinal and transverse seiche currents, and “high”‐frequency velocity fluctuations, using digital filters. The analysis of components shows that mean currents are most pronounced in early winter and are

During spring and autumn a special thermohydrodynamic phenomenon, called a thermal bar, can be observed in dimictic lakes. [A dimictic lake is a lake where a complete turnover of the water occurs twice a year (in spring and autumn).] The thermal bar is a zone of mixing that separates waters with temperatures above and below 4° C. Its practical importance is due to the possibility that it might iso

During late winter (18 March–7 April 1994), temperature and current measurements were made in Lake Vendyurskoe, Russia, including three surveys at six cross sections of the lake. Also, the temperature profile evolution was registered with two thermistor chains at two stations (bottom depths of 7.6 and 11.5 m) until the time of ice breakup. Temperature gradients were measured just below the ice cov

Field data on temperature and salt content structure in the vicinity of the bottom boundary in an ice‐covered lake are analyzed. A bottom boundary layer is identified, characterized by rapid increases in both temperature and salt concentration and having a thickness of ∼1 dm with respect to temperature and 2–4 cm with respect to salt content. A simple analytical model of the temperature distributi

We use a combination of field and satellite data to investigate the thermal regime in Lake Ladoga in spring 1992. The analysis concentrates mainly on the temperature structure in the convectively mixed region and the dynamics of a special thermo‐hydrodynamic phenomenon called “thermal bar” (a zone of descending water with the temperature of maximum density equal to ∼4°C). A theoretical model of th