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Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO

Plasmodium falciparum is the causative agent of the most severe type of malaria, a life-threatening disease affecting the lives of over three billion people. Factors like widespread resistance against available drugs and absence of an effective vaccine are seriously compounding control of the malaria parasite. Thus, there is an urgent need for the identification and validation of new drug targets.

Individual variation and repeatability of sex pheromone emission of female turnip moths Agrotis segetum

Individual variation of the female sex pheromone signal in Agrotis segetum was determined by gas chromatographic analysis. The individuals varied extensively, both in absolute and relative amounts of the three major pheromone components; Z5-10:OAc, Z7-12:OAc and Z9-14:OAc. Within individuals there was a strong correspondence between the sex pheromone gland content and the signal actually emitted.

Interpretation of EXAFS spectra for sitting-atop complexes with the help of computational methods

The metallation of tetrapyrroles is believed to proceed via a sitting-atop (SAT) complex, in which some of the pyrrole nitrogen atoms are protonated and the metal ion resides above the ring plane. No crystal structure of such a complex has been presented, but NMR and EXAFS (extended X-ray absorption fine structure) data has been reported for Cu2+ in acetonitrile, which have been interpreted as the

Soil carbon sequestration in traditional farming in Sudanese dry lands

Do altered land management practices offer possibilities to sequester carbon in the soil and thereby mitigate increasing atmospheric CO2 as well as improve local soil fertility? This study investigates the impact of fallow periods on soil organic carbon in semiarid subsistence agroecosystems on sandy and poor soils in Kordofan, Sudan. The area is characterized by low-input cultivation of millet an

Dietary thylakoids reduce visceral fat mass and increase expression of genes involved in intestinal fatty acid oxidation in high-fat fed rats

Thylakoids reduce body weight gain and body fat accumulation in rodents. This study investigated whether an enhanced oxidation of dietary fat-derived fatty acids in the intestine contributes to the thylakoid effects. Male Sprague-Dawley rats were fed a high-fat diet with (n = 8) or without thylakoids (n = 8) for 2 wk. Body weight, food intake, and body fat were measured, and intestinal mucosa was

How well do capability assessments reflect actual capability? – An experimental study of capability assessments with multi-actor dependencies

In order to cater for the increasingly complex society several countries have adopted a capabilities-based planning approach, including capability assessments, as part of their preparedness for disasters. Since the number of actors who are dependent on each other is increasing, capability assessments are made based on assumptions of other actors’ capabilities. It is therefore crucial to understand

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Description and analysis of Swedish excise duties and Swedish tax policy in field of environmental friendly tax incentives

Optimizing flow thinning protection in multicommodity networks with variable link capacity

Flow thinning (FT) is a concept of a traffic routing and protection strategy applicable to communication networks with variable capacity of links. In such networks, the links do not attain their nominal (maximum) capacity simultaneously, so in a typical network state only some links are fully available whereas on each of the remaining links only a fraction of its maximum capacity is usable. Every

Automated linked data generation from the transport administration domain

The Linked Data approach in data publishing allows the users and their data-driven applications to have broader use cases which encompass various data sources, either publicly available on the Web, or in private repositories. The use of W3C standards in publishing such data enables uniform access across platforms. Transport information today has higher importance to the citizens and society than e