Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated “terminal selectors.” Using BM chimeras, condit

The 3-step falls prediction model (3-step model) that include history of falls, history of freezing of gait and comfortable gait speed

Summary: This study used nationwide hip fracture data from Denmark and Sweden during 1987–2010 to examine effects of (birth) cohort and period. We found that time trends, cohort, and period effects were different in the two countries. Results also indicated that hip fracture rates may increase in the not so far future. Introduction: The reasons for the downturn in hip fracture rates remain largely

We consider Chebyshev polynomials, (Formula presented.), for infinite, compact sets (Formula presented.) (that is, the monic polynomials minimizing the (Formula presented.)-norm, (Formula presented.), on (Formula presented.)). We resolve a (Formula presented.) year old conjecture of Widom that for finite gap subsets of (Formula presented.), his conjectured asymptotics (which we call Szegő–Widom as

For the purpose of this paper, Erbil city, located in the northern part of Iraq, has been chosen as a representative case study for a large number of cities, particularly in semi-arid areas, lacking sustainable drainage systems (SuDS). The study assesses (a) the role of SuDS as a measure in areas with a water shortage; (b) water scarcity in decision-making processes; (c) the lack of legislation to

The inclusive gluon production at midrapidities is described in the color glass condensate formalism using the kT-factorization formula, which was derived at fixed coupling constant considering the scattering of a dilute system of partons with a dense one. Recent analysis demonstrated that this approach provides a satisfactory description of the experimental data for the inclusive hadron productio

The effects of temperature-dependent thermophysical properties on droplet flow characteristics in a parallel-plate channel at submicron scale are investigated. The dissipative particle dynamics method with many-body (MDPD) and energy conservation (DPDe) configurations (MDPDe) was used. Droplet flows were simulated to study the effects of the temperature difference between top and bottom walls, bod

Oil palm plantation expansion is occurring at a rapid pace. However, substantial yield losses from pest attacks are becoming major threats to the oil palm industry, while the potential role of conservation biological control, a sustainable and environmentally friendly solution for pest control, is still largely unknown. The type of vegetation surrounding oil palm plantations is likely to influence

Because natural gas resources continue to be depleted for usage of gas turbines, it becomes important to search for alternate fuels. Coal-derived synthetic fuels contain traces of ash and other contaminants that result in deposition on vane and turbine surfaces. The present research shows a comparison of simulated results with and without a deposition configuration. Film cooling effectiveness dist

Introduction: Although the group of vascular leg amputated patients constitutes some of the most vulnerable and frail on the orthopedic wards, previous research of amputated patients has focused on patients attending gait training in rehabilitation facilities leaving the patient experience shortly after surgery unexplored. Understanding patients' behavior shortly after amputation could inform heal

Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective phytotoxins. Alt a 1 is a strongly allergenic protein found in A. alternata that causes severe asthma. Despite the well-established pathogenicity of Alt a 1, the molecular mechanisms underlying its action and physiological function r

Ultraviolet (UV) light occupies the spectral range of wavelengths slightly shorter than those visible to humans. Because of its shorter wavelength, it is more energetic (and potentially more photodamaging) than 'visible light', and it is scattered more efficiently in air and water. Until 1990, only a few animals were recognized as being sensitive to UV light, but we now know that a great diversity

Background and purpose — Early postoperative mortality is relatively high after total hip arthroplasty (THA) that has been performed due to femoral neck fracture. However, this has rarely been investigated after adjustment for medical comorbidity and comparison with the mortality in an age-matched population. We therefore assessed early mortality in hip fracture patients treated with a THA, in the

A comprehensive experimental investigation relevant to thermal radiation has been performed in a grate-fired test furnace. Thermal radiation is the dominating mode of heat transfer in the grate-fired furnace and yet only a few studies have focused on thermal radiation. No previous works, to the authors' knowledge, have been carried out concerning measurements on radiative heat transfer in grate-fi

The positive δ13C excursion associated with the Late Silurian Lau Event is recognized globally and is the most prominent carbon isotope excursion of the Phanerozoic. We present new δ13C data (195 samples) and the first continuous carbon isotope stratigraphy across the stratigraphic range of this bioevent based on two drill cores from Gotland, the informal type area for the Lau Event. The positive

Ion beam analysis has for decades been used as a tool for geochemical analysis of trace elements using both X-rays (particle induced X-ray emission) and nuclear reaction analysis. With the geoanalytical setup at the Lund Ion Beam Analysis Facility, the boron content in geological samples with a spatial resolution of 1 µm is determined through nuclear reaction analysis. In the newly upgraded setup,

Vacuum degassing of activated sludge was tested at eight different Swedish wastewater treatment plants with laboratory-scale equipment in batch mode in order to evaluate its efficiency on improvement of sludge compaction and settling properties. The results show that the efficiency of the degassing technique is mainly dependent on the initial sludge volume index (SVI) of the target sludge which wa

Background and purpose — Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of

Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is centr

Forest fires are an important disturbance factor of boreal forests, annually burning about 0.5% of the forested area in Canada. Wildfire regimes are influenced by climate and a number of studies project an increase in wildfire activity with climate change. Another factor influencing wildfires is human intervention (fire suppression), and one factor that has rarely been assessed is fuel fragmentati