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C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice.

OBJECTIVES: To assess the human complement inhibitor C4b-binding protein (C4BP) for treatment of arthritis. METHODS: We have used two mouse models of rheumatoid arthritis (RA) to assess the therapeutic effect of C4BP on different phases of arthritis, the collagen antibody induced arthritis (CAIA), an acute antibody induced disease and the collagen induced arthritis (CIA), which carries the full co

Degradation of dissolved and sorbed 2,4-dichlorophenol in soil columns by suspended and sorbed bacteria.

The influence of sorption of bacteria, as well as 2,4-dichlorophenol (2,4-DCP), on the mineralization of 100 microg l(-1) of the organic compound was examined in an aquifer material under advective flow conditions (column displacement technique). The study was designed to distinguish the rates and extent of biodegradation of the sorbed and the dissolved trace organic and the contribution of sorbed

Results of surgery for sporadic primary hyperparathyroidism in patients with preoperatively negative sestamibi scintigraphy and ultrasound.

PURPOSE: The purpose of this study is to investigate the results of first-time surgery for sporadic primary hyperparathyroidism (pHPT) in patients with preoperatively negative sestamibi scintigraphy and ultrasound. METHODS: Data were gathered prospectively in a multicenter database for quality control in parathyroid surgery. Between 2004 and 2008, 3,158 patients underwent first-time surgery for sp

Disturbance detection in wastewater treatment plants

The development in sensor technology has made many wastewater treatment systems data rich but not necessarily information rich. To extract the adequate information from several sensors is not trivial, and it is not sufficient to consider only the time series. Different tools for detecting unusual on-line measurement data and deviating process behaviour are discussed. In this paper various dimensio

A Taxonomy for Requirements Engineering and Software Test Alignment

Requirements Engineering and Software Testing are mature areas and have seen a lot of research. Nevertheless, their interactions have been sparsely explored beyond the concept of traceability. To fill this gap we propose a definition of requirements engineering and software test (REST) alignment, a taxonomy that characterizes the methods linking the respective areas, and a process to assess alignm

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation.

A common mammalian defense mechanism employed to prevent systemic dissemination of invasive bacteria involves occlusion of local microvasculature and encapsulation of bacteria within fibrin networks. Acquisition of plasmin activity at the bacterial cell surface circumvents this defense mechanism, allowing invasive disease initiation. To facilitate this process, S. pyogenes secretes streptokinase,