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The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and phaeomelanin (5-S-cysteinyl-dopa, 5-S-CD). To determine whether chloroquine inte
Popular Abstract in Swedish Under 1100-talet utvecklades inom kanonisk rätt principen att makarnas samtycke är tillräckligt för att skapa ett giltigt äktenskap. Varken familj eller andra auktoriteter, inte ens kyrkliga, hade laglig bestämmanderätt över två personers giftermål. Denna lagstiftning stod i konflikt med det sekulära samhällets uppfattning av äktenskapet och även i vissa fall med kyrkanOne of the most important aspects of the marriage legislation in medieval canon law is the doctrine of free choice. According to this doctrine, established by pope Alexander III in the second half of the twelfth century, the validity of a marriage depended solely on the freely given consent of the parties. Neither family nor witnesses, not even the presence of a priest were necessary to form a val
This report presents the fifth and last experiment in a longitudinal study of text building behaviour at the Gymnasium level of a Swedish School. The series of experiments concerns natural language production as a means for the establishment of state attractors as well as their geometric space descriptions. The hypothesis tested during three years of instruction and learning is whether the evolvin
Introduction: Early enteral nutrition with fibre and probiotics has been effective in preventing bacterial translocation and is therefore expected to reduce the incidence of postoperative bacterial infections. Patients and methods: In a prospective randomized trial including 172 patients following major abdominal surgery or liver transplantation, the incidence of bacterial infections was compared
Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+protects against inactivation and modification, in agreement with the study onE. colidUTPase (Vertessyet al.(1994)Biochim. Biophys. Acta1205, 146-150). Amino acid analyses of nitrated dUTPases
OBJECTIVE: A prenatal diagnosis of the fetus for a mother of two previously deceased infants who died from the recently described autosomal recessive disease (OMIM 603358). The infants presented with intrauterine growth retardation, aminoaciduria, cholestasis, iron overload, severe lactic acidosis, and early death (GRACILE syndrome). STUDY DESIGN: DNA was extracted from the fibroblasts and tissue
The effect of the presence of water vapor on the reduction of nitric oxide with ammonia was investigated using vanadia on SiO2-TiO2 as a catalyst. The selectivity towards nitrogen is greatly increased upon addition of water. Repeated use at temperatures of 825 K causes sintering of the catalyst and loss of activity as well as selectivity towards nitrogen. The formation of nitrous oxide is preferen
Popular Abstract in Swedish Många material som ingår i tillverkade varor har kvar sina kvaliteter även när varorna är uttjänta. Men bara en liten del av dessa material återvinns idag på ett sätt som gör det möjligt att återanvända materialet för samma syfte och med bevarade egenskaper. I allmänhet har det industriella samhället fortsatt att praktisera en slit- och slängmentalitet, trots att det beMany anthropogenically-produced or beneficiated materials contained in “end-of-life” products retain a great proportion of the invested manufacturing work when discarded. Very few such materials are reconstituted and applied in new products at the same material inherent quality level as in their first lifetime – a process known as “closed-loop recycling”. In general, industrial society maintains a
The effect of pixel size on shape determination in screening digital mammography systems was studied using a shape identification task as the measured outcome. Ten microcalcifications on screen-films were digitised to a range of pixel sizes (2.5-200 μm) and extracted from computed radiography (CR) images (50 μm) acquired under equivalent imaging conditions. Fifteen observers attempted to identify
As shown in a companion paper the geometrical diameter of a hair strand is an important parameter for quantification of its trace element content after PIXE analysis. By analysing Rutherford backscattered protons simultaneously with PIXE analysis a reliable estimate of the hair diameter can be obtained. In this work the hypothesis that there exists a linearity between the geometrical diameter and
Distributions of tumor necrosis factor (TNF) and its soluble receptor forms, R55-BP and R75-BP, were analyzed in the cerebrospinal fluid of patients with severe acute or chronic central nervous system infections. Tuberculous infections were associated with high ratios of R55-BP and R75-BP to TNF, 27.2 and 28.0, respectively, suggesting a small biologically active fraction of TNF. The opposite was
Objectives: To describe the physiological properties of the peritoneal membrane in adult patients treated with peritoneal dialysis (PD) and to analyze the effects of patient characteristics and time. Design: Observational study. Setting: Department of Nephrology at the Sahlgrenska University Hospital. Method: Peritoneal function was analyzed by the Personal Dialysis Capacity (PDC) test, based on t
Residual masses are frequently found in patients with aggressive lymphomas, following therapy. A study was undertaken to determine whether initial tumour size, changes during treatment, or size of the residual mass could provide prognostic information. Computed tomography (CT) examinations were carried out before, midway and after completion of chemotherapy in 37 patients with aggressive lymphoma
Diabetic nephropathy is a common complication in diabetes mellitus. In addition to the risk of renal failure, patients with established nephropathy are at increased risk of proliferative retinopathy and cardiovascular disease. As the earliest prodrome of nephropathy is microalbuminuria, albumin excretion needs to be monitored with a reliable method in all diabetics. In the event of microalbuminuri
We consider an exhaustive polling system with three nodes in its transient regime under a switching rule of generalized greedy type. We show that, for the system with Poisson arrivals and service times with finite second moment, the sequence of nodes visited by the server is eventually periodic almost surely. To do this, we construct a dynamical system, the triangle process, which we show has even
Popular Abstract in Swedish Modellering och simulering är etablerade tekniker för att lösa designproblem inom många olika ingenjörsdiscipliner idag. Dedicerade språk, såsom Modelica, och effektiva mjukvaror finns också tillgängliga. I denna avhandling presenteras en språklig utvidgning av Modelica, Optimica, som är avsedd för formulering av dynamiska optimeringsproblem. För att demonstrera användnModeling and simulation are established techniques for solving design problems in a wide range of engineering disciplines today. Dedicated computer languages, such as Modelica, and efficient software tools are available. In this thesis, an extension of Modelica, Optimica, targeted at dynamic optimization of Modelica models is proposed. In order to demonstrate the Optimica extension, supporting sof
