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Functional Characterization of Mutations in STUB1, a Protein Involved in the Protein Turnover System, in Patients with Autosomal Recessive Cerebellar Ataxia

Popular science summary: Recessive mutations in STUB1 cause cerebellar ataxia Autosomal recessive cerebellar ataxias (ARCA) constitute a group of rare disorders characterized by ataxia due to cerebellum neurodegeneration. Here we characterize three novel mutations in the STUB1 (STIP1 homology and U-box containing protein) gene as the cause of ARCA in two families. STUB1 encodes CHIP (C-terminus

Communicating beyond the word - designing a wearable computing device for Generation Z

Humans have always communicated with each other. When the smartphone technology was launched on the market, it revolutionized the way people communicate. This smartphone technology is constantly evolving and during 2014 wearable computing seems to be in the focal point at most smartphone technology conferences. This master thesis aims to discover how a wearable computing device can further develo

Rättsliga förutsättningar för utvecklingen av vindkraft -En granskning av tillståndsprövningen enligt miljöbalken och plan- och bygglagen

Den svenska riksdagen har höga ambitioner om att utveckla den förnyelsebara energin i allmänhet och vindkraften i synnerhet. Nationella energi- och miljöpolitiska mål har antagits för att förenkla etableringar och således skapa förutsättningar för en utveckling av vindkraften i Sverige. Ambitionerna är högt ställda men politiska ställningstagande kräver verkställighet och resultatet av det finner The Swedish Parliament sets high ambitions in order to develop renewable energy in general and wind energy in particular. National energy and environmental policies have been adopted to facilitate wind power establishments and thus create conditions for development of wind power in Sweden. The ambitions are high but political positions requires enforcement and the result of the objectives are foun

Hemliga tvångsmedel – En studie om avvägningen mellan effektivitet och rättssäkerhet vid bekämpande av de mest allvarliga brotten

The laws of “secret room interception” and “actions to prevent certain serious crimes” took effect in January 2008. A year later the law of “actions to investigate certain crimes that are dangerous to society” was enforced. All three laws gave the law enforcement authorities new conditions for the use of secret coercive measures. The law enforcement authorities are entitled to use secret room inte

Oärliga mål och spoiling - En kritisk analys av privata aktörers förehavanden i resurskonflikter

This essay’s objective is to problematize the presence of private actors in protracted conflicts in resource rich states. Constructive engagement is a term that has justified the presence of private actors in war-torn states and functions as a political shield for private actors, something the essay is critical towards. Through the use of critical spoiler-theory and theory-testing process tracing

Marknaden som skäl för löneskillnader. En uppsats om marknadsargumentet i lönediskrimineringstvister

Likalöneprincipen innebär rätten till lika lön för kvinnor och män för lika eller likvärdigt arbete. Likalöneprincipen återfinns bl.a. i FNs förklaring om de mänskliga rättigheterna från 1948 och principen har varit en viktig del av EU-rätten sedan Romfördraget. I uppsatsen redogör jag för hur likalöneprincipen har utvecklats inom unionsrätten och i svensk rätt. Fokus ligger på det s.k. marknadsarThe equal pay principle can be found in several international conventions, such as in the United Nations Universal Declaration of Human Rights as well as in The Treaty on the Functioning of the European Union. The main focus of this essay is to look in to the equal pay principle and how it has developed within the European Union as well as in Sweden. The main focus is on the market factor as it is

Paddy and banana cultivation in Sri Lanka : a study analysing the farmers’ constraints in agriculture with focus on Sooriyawewa D.S. division

The farmers in Sooriyawewa D.S. division, situated in the Dry Zone in Sri Lanka, are main cultivators of paddy and banana. The agriculture in the Dry Zone is heavily depending on water from the irrigation schemes. The objective of the study is to investigate the methods used in the paddy and banana cultivation in Sri Lanka with focus on Sooriyawewa D.S. division in order to understand the main con

Rätten att dö- en komparativ studie om eutanasi och om möjligheterna att införa dödshjälp i svensk rätt

Sammanfattning Människans rätt till självbestämmande är en grundläggande rättighet som i de allra flesta sammanhang i livet tillskrivs stor betydelse. Även inom hälso- och sjukvården betonas respekten för människans integritet och autonomi. När det gäller livets slutskede och människans rätt att styra över hur och när hon vill avsluta sitt liv får självbestämmanderätten emellertid vika till förmåSummary The human right to self-determination is a fundamental right, which in most situations in life is considered to be of high importance. This approach also applies in the department of medical care, in which the respect for the individual integrity and autonomy is emphasized. Regarding the final stages of life, the right to self-determination and the right to control how and when a person w

Olovligt spridande av privata bilder på internet

Uppsatsen redogör för rättsläget kring olovligt spridande av privata bilder på internet. I dagsläget bedöms sådant spridande vanligtvis som förtal i Sverige. För att något ska utgöra förtal ska en uppgift ha spridits som varit ägnad att utsätta personen för andras missaktning. Bedömningen av huruvida en uppgift varit ägnad att utsätta en person för andras missaktning och huruvida personens ära bliThe subject of this essay is the legal situation regarding unauthorized distribution of private photos on the Internet. Today, such distribution is usually judged as defamation in Sweden. For something to constitute defamation, information shall have been spread that was intended to subject the person to other people's contempt. The determination of whether a statement was likely to expose a p

EU: Education Policies and Third Countries. Civilian Power or "Just" Foreign Policy?

Despite the lack of attention from academia, there are concrete examples that show an attempt to Europeanize the education policies and institutions of countries outside of the EU. This dissertation investigates the relationship between education and foreign policy, looking at the partnership between EU and third countries. Following a social constructivist theoretical framework, the results of th

Laglottsskyddet i moderna familjekonstellationer - Förskott på arv och det förstärkta laglottsskyddet

Denna uppsats ska utreda och diskutera ifall syftet med arvsrättens regler om förskott på arv och det förstärkta laglottsskyddet uppfylls för bröstarvingar i moderna familjekonstellationer. Gällande rätt avseende förskott på arv och det förstärkta laglottsskyddet har studerats. Dessa två institut reglerar gåvor som föräldrar, under sin livstid, givit till något barn och hur gåvorna ska hanteras vi

Quantification and Implementation of Structural Damping in MBS Flexible Bodies

In multi body simulation (MBS) using flexible bodies, damping is an important model input to be able to predict the response of a structure with sufficient precision. The purpose of this thesis has been to estimate the structural damping of an experimental setup and implement the estimated damping into MBS-models of the setup. In this thesis the modal properties in terms of natural frequencies, m

TRIPS and ICT Developments in Developing Countries: Do ‘One-Size-Fits-All’ Standards Work?

Since the introduction of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), its impacts on developing countries have been widely discussed by scholars. In this article, we focus on the impacts of stronger Intellectual Property protection, pushed by TRIPS, on Information and Communications Technology (ICT) potentials and performances of the developing countries at diff

Omdimensionering av Lunds fjärrvärmenät

Fjärrvärmenät för ett energieffektivare Lund Lund är en stad i förändring. En helt ny design på fjärrvärmenätet skulle kunna vara en lösning på många problem. I dagens samhälle ses ett uppvärmt hem som en självklarhet. Men värmen uppkommer inte av sig själv. För att värma sitt hem använder många idag fjärrvärme då detta är både en smidig, miljövänlig och ofta billig lösning. I Lund har fjärrvärmeLund is a rapidly growing city, and in a short time two new research facilities, ESS and MAX IV, will be completed. These facilities will deliver their excess heat to the district heating network of Lund which puts a high demand on the network. Kraftringen Energi AB, which owns and operates the network, are also in the process of replacing old pipes which motivates a through investigation of which

Has the Maputo Declaration Made a Difference? - Looking at the past ten years of Sub-Saharan agriculture within the CAADP

The Maputo Declaration was launched in 2003 as a response to the stagnation of African agriculture. The signatories agreed that 10% of public expenditure should be spent on agriculture in an effort to increase agricultural productivity. This paper examines to what degree the goal of the Maputo declaration has been reached. Little to no evidence was found for a direct positive impact on agricultura

Feasibility of Implementing the PILATUS CdTe 300k Detector as a Real Time Gamma Camera in Intraoperative Medical Imaging

Att kunna se igenom människor Att kunna flyga, vara osynlig och ha röntgensyn – de superkrafterna är det många som önskar sig. Faktum är att röntgensyn är en verklighet; man måste bara få tag på lite speciell utrustning. På sjukhus runtom i världen används det dagligen medicinska avbildningtekniker som antingen grundar sig på röntgenstrålar eller andra former av strålning. Dessa tekniker hjälperThe full-width-at-half-maximum of the point spread functions for a pixellated cadmium telluride detector exposed to gammas from a 140.5 keV Tc-99m source are modelled in GATE, at a detector-collimator distance of 5 cm, and collimator-source distances of 5 cm and 10 cm, with lead pinholes of diameter 1.0 mm, 1.5 mm, 2.0 mm and 5.0 mm acting as collimators. The PILATUS3 X CdTe 300k detector from Dec

Governing for Sustainability: Between Post-political Participation and Apathy in an Argentinian Neighbourhood

Despite the increased focus on sustainable urban development both within academia and in urban planning practices, authors seem to agree that we are mostly continuing business as usual and are not embarking on different socio-environmental trajectories. On the contrary, such urban sustainability practices can often lead to processes of displacement and gentrification, thus worsening the conditions

In the Eye of the Storm: The connection between extreme weather events and human trafficking in the case of typhoon Haiyan in the Philippines.

Considering climate change, the continuous degradation of the environment, and the uneven distribution of resources, this research project aims to shed light on the social vulnerability of people experiencing extreme weather events and possible connections to social phenomena. Specifically, this project focuses on how vulnerability to extreme weather events affects vulnerability to human trafficki

Perception of perfection

In this project I discuss perfection and perfectionism. The ideals in our society are challenging and sometimes impossible to live by. This goes for everything from social life, to looks and career. I based the research both on readings, talks, experiments and a own observations. In a survey I found that most of the participants that was in design school felt a lot of performance anxiety, and tha