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A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient

Particle formation events were analysed from aerosol number size distribution data collected at a background station in southern Sweden between February 2001 and May 2004. Events occurred on about 36% of all days and were favoured by high global radiation values. The clearest events (class I, 20% of all days) were observed when the formation rate of activated hypothetical clusters around 1 nm diam

The protein kinase C (PKC) family of serine/threonine kinases consists of 10-15 members. The PKC isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. The PKC family can be subgrouped into classical, novel and atypical isoforms depending on structure and sensitivity to the activators diacylglycero

Popular Abstract in English In an organism the DNA contains the entire biological information that is needed to be able to exist and function. Those segments, also known as DNA sequences are a genetic code, which is further packaged into units called genes. The entity of all genes is called genome. Today we know, that only a small proportion of genes encode for proteins, which are responsible for More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbio

Abstract in UndeterminedThe aim of this article is to explore how young women with physical impairments make use of technology in their identity construction, drawing on the metaphor of the cyborg as well as on science and technology studies and disability research. In addition to participant observation, semi-structural interviews were conducted and video diaries were kept of the women playing sl

This paper investigates a time interval within the Late Ludfordian (Late Silurian), involving changes in faunal composition (the Lau Event), a major positive carbon isotope excursion (CIE), and contemporaneous sea-level changes in remote palaeo-basins. Based on the Silurian strata of Gotland (Sweden), we integrate sequence stratigraphy, carbon isotope stratigraphy, and platform-scale palaeoecologi

This paper presents investigations on the limitations of intensified CCD (ICCD) cameras when performing quantitative 2D temperature measurements using thermographic phosphors. The temperature is evaluated using a two-color ratio technique, which demands high signal linearity of the detector. However, this work shows that the ICCD cameras used suffer from nonlinearity at levels of irradiance that d

We constrain the densities of Earth-to Neptune-size planets around very cool (T-e = 3660-4660 K) Kepler stars by comparing 1202 Keck/HIRES radial velocity measurements of 150 nearby stars to a model based on Kepler candidate planet radii and a power-law mass-radius relation. Our analysis is based on the presumption that the planet populations around the two sets of stars are the same. The model ca

The underlying causes of incident fractures-bone fragility and the tendency to fall-remain under-diagnosed and under-treated. This care gap in secondary prevention must be addressed to minimise both the debilitating consequences of subsequent fractures for patients and the associated economic burden to healthcare systems. Clinical systems aimed at ensuring appropriate management of patients follow

Models of small clutch sizes predict a number of invariant relationships between means and variances of measures of reproductive investment. However, empirical tests of the models have been lagging behind theoretical work. We tested the predictions using data on the mallee dragon, Ctenophorus fordi, a species where the basic assumptions of the models are likely to be fulfilled. Some, but not all,

The most common malignant brain tumor in adults is a glioma called glioblastoma multiforme (GBM). About 300 persons are diagnosed with GBM every year in Sweden. Unfortunately, it is also the most aggressive brain tumor and as of today, it is not possible to cure it. Despite treating the patients with surgery, radiation and chemotherapy, the median survival is only 15 months. The main problem with

Many cyber-physical systems comprise several control applications implemented on a shared platform, for which stability is a fundamental requirement. This is as opposed to the classical hard real-time systems where often the criterion is meeting the deadline. The stability of control applications depends on not only the delay experienced, but also the jitter. Therefore, the notion of deadline is c

Interest in high spatial resolution boron analyses from a geochemical perspective is related to the recognition of boron as an important tracer of chemical recycling in the Earth, due to the high solubility of boron in aqueous fluids and silicate melts. Although boron is not a nominal component in common silicates they may still contain significant B-concentrations and hence constitute important b

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Vad är ljumskbråck och hur vanligt är det ? Bråck är en försvagning i bukväggen genom vilken bukhinnan och bukinnehåll kan bukta ut så att en knöl kan kännas. Bråck i ljumsken kan vara medfödda eller utvecklas med stigande ålder då vävnaden försvagas. Ljumskbråcken kan indelas i två typer: inguinala och femorala (lårbråck). De inguinalBackground: According to the Swedish Hernia Register (SHR), the reoperation rate after recurrent groin hernia is more than twice that following primary hernia repair. Aims: To study the impact of method of mesh repair used in recurrent groin hernia surgery on re-recurrence as well as chronic pain and physical disability. Methods: Papers 1 and 2 were based on nationwide data from the SHR 1992-2008.

We generalize a well-known sufficient condition for interpolating sequences for the Hilbert Bergman spaces to other Bergman spaces with normal weights (as defined by Shields and Williams) and obtain new results regarding the membership of the derivative of a Blaschke product or a general inner function in such spaces. We also apply duality techniques to obtain further results of this type and obta

Scavengers play a major role in the waste management process in developing countries. This study analyzed the informal recycling activities carried out by scavenger in the Tafila region of Jordan. The results show that scavengers have an important role in the informal solid waste management (SWM) especially in term of waste reduction, minimization and material recovery. Significant values from the

Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a medi

Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-