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Following systemic injection, hematoporphyrin derivative (HPD) is known to be selectively retained in malignant tissue. This property can be used in a two-fold way: a) for localizing tumours by observing the characteristic dual-peaked laser-induced fluorescence from HPD, and b) for photodynamic therapy (HPD-PDT) using a localized HPD-assisted singlet oxygen release induced by irradiation of 630 nm

The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in several tissues and identify netrin-4 (Net4) as a key regulator of BM stiffness. Mechanistically, our biophysical and functional analyses in combination w

We consider the problem of outsourcing computation on data authenticated by different users. Our aim is to describe and implement the simplest possible solution to provide data integrity in cloud-based scenarios. Concretely, our multi-key linearly homomorphic signature scheme (MKLHS) allows users to upload signed data on a server, and at any later point in time any third party can query the server

Loss and damage from climate change, recognized as a unique research and policy domain through the Warsaw International Mechanism (WIM) in 2013, has drawn increasing attention among climate scientists and policy makers. Labelled by some as the “third pillar” of the international climate regime—along with mitigation and adaptation—it has been suggested that loss and damage has the potential to cata

Current levels of global warming (Haustein et al. 2017) have already intensified heat waves, droughts, and floods, with many recent events exhibiting evidence of being exacerbated by anthropogenic climate change (e.g., Herring et al. 2016, 2018). Recent improvements in understanding demonstrate that half a degree of additional warming will have further severe impacts (Masson-Delmotte et al. 2018).

Homomorphic authenticators (HAs) enable a client to authenticate a large collection of data elements m1, …,mt andoutsource them, along with the corresponding authenticators, to an untrusted server. At any later point, the server can generatea short authenticator σf , y vouching for the correctness of the output y of a function f computed on the outsourced data, i.e.y = f (m1, …,mt). The notion of

As messaging applications are becoming increasingly popular, it is of utmost importance to analyze their security and mitigate existing weaknesses. This paper focuses on one of the most acclaimed messaging applications: Signal. Signal is a protocol that provides end-to-end channel security, forward secrecy, and post-compromise security. These features are achieved thanks to a key-ratcheting mechan

Ridesharing is revolutionizing the transportation industry in many countries. Yet, the state of the art is based on heavily centralized services and platforms, where the service providers have full possession of the users’ location data. Recently, researchers have started addressing the challenge of enabling privacy-preserving ridesharing. The initial proposals, however, have shortcomings, as some

Multi-Key Homomorphic Signatures (MK-HS) enable clients in a system to sign and upload messages to an untrusted server. At any later point in time, the server can perform a computation C on data provided by t different clients, and return the output y and a short signature σC,y vouching for the correctness of y as the output of the function C on the signed data. Interestingly, MK-HS enable verifie

OBJECTIVES: To analyse the association between ABO blood group and aortic disease using data on blood donors and transfused patients from Sweden. DESIGN: This was a retrospective study using data from the Swedish portion of the Scandinavian Donations and Transfusions Database. The association between ABO blood group and aortic disease was analysed using log-linear Poisson regression models and pre

An emerging direction for authenticating people is the adoption of biometric authentication systems. Biometric credentials are becoming increasingly popular as a means of authenticating people due to the wide range of advantages that they provide with respect to classical authentication methods (e.g., password-based authentication). The most characteristic feature of this authentication method is

In biometric authentication protocols, a user is authenticated or granted access to a service if her fresh biometric trait matches the reference biometric template stored on the service provider. This matching process is usually based on a suitable distance which measures the similarities between the two biometric templates. In this paper, we prove that, when the matching process is performed usin

AIM Enterococci cause 2-11% of all prosthetic joint infections (PJI) and are generally considered difficult to treat. However, study-results are not consistent. In this study we present a population-based case series of 55 cases with enterococcal PJI, investigating treatment and outcome, as well as describing the affected patient population regarding demography and co-morbidities. METHODS We ident

How do you take a reliable measurement of a material whose microstructure is random? When using wave scattering, the answer is often to take an ensemble average (average over time or space). By ensemble averaging we can calculate the average scattered wave and the effective wavenumber. To date, the literature has focused on calculating the effective wavenumber for a plate filled with particles. On